CAS: 1122-96-9; 4-Methoxypyridine N-Oxide

该化合物是一种环环环化合物,在4位置上用甲氧基组替换为核核心,并使用N-氧化二氧功能化.这种改变增强了它的极度和反应性,使其成为有机合成中的宝贵中间体,特别是在制药和农用化学应用中.N-xion modie 有利于选择性的转化,如核生殖替代或金属催化结,而甲基氧组则能够影响电子特性和稳定性.其定义明确的结构和合成多功能性使得它可用于制造复杂的分子.该化合物由于潜在的敏感性,通常在受控制的条件下处理.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号620-08-6 4-甲氧基吡啶 | CAS号1124-33-0 4-硝基吡啶-N-氧化物 | CAS号124-41-4 甲醇钠 | CAS号67-56-1 甲醇 | CAS号137858-02-7 4-(N-pyridinium... | CAS号10296-38-5 Pyridine, 4-azi... | CAS号2683-66-1 4-苄氧基吡啶-N-氧化物 | CAS号14248-50-1 4-溴吡啶n-氧化物 | CAS号186581-53-3 重氮甲烷 | CAS号107971-38-0 PHENYL 3,4-DIHY... | CAS号112266-45-2 (4-methoxypyrid... | CAS号36057-44-0 4-甲氧基氰基砒啶 | CAS号4043-87-2 2-哌啶甲酸 | CAS号70197-13-6 甲基三氧化铼(MTO) | CAS号98303-20-9 N-B°C-2-哌啶甲酸 | CAS号82257-15-6 4-甲氧基-3-吡啶甲醛 | CAS号956485-64-6 3-碘-4-甲氧基-吡啶-2-胺 | CAS号52545-13-8 无中文名(订作4-5周) | CAS号620-08-6 4-甲氧基吡啶

合成工艺路线路线简述

  • 合成目标产物 4-Methoxypyridine N-Oxide 主要起始原料 4-Methoxypyridine
  • (文献来源)合成步骤主要原料 4-Methoxypyridine
4-甲氧基吡啶置于间氯过氧苯甲酸体系中,用 二氯甲烷 用作溶剂,化学反应生成4-甲氧基吡啶-N-氧化物
参考文献:吡啶衍生物的可见光介导的ch烷基化.
标题:吡啶衍生物的可见光介导的ch烷基化.
摘要:我们在这里报告了吡啶衍生物的可见光介导的ch烷基化反应,该反应通过在2 Mol%的fac-Ir(ppy)3存在下在蓝色光照下将多种n-烷氧基吡啶鎓离子与烷烃简单组合而进行.温和的反应条件以及较高的基团功能耐受性使该方法成为构建结构应变杂环的有用合成平台.详细的机械研究,包括密度泛函理论计算和量子产率测量,使我们能够了解控制反应活性和反应选择性的因素.
Doi:10.1021/acs.Orglett.0C02863

海关参考信息

专利信息


专利号:US-2002015965-A1
优先权日:2000-07-27
标题:Efficient synthesis of triboluminescent lanthanide complexes
发明人:SWEETING LINDA MARIE
摘要:Lanthanide complexes of β-diketonates which incorporate amines or their salts have been shown to exhibit intense photoluminescence and triboluminescence. These triboluminescent materials show a great deal of promise for remote sensing of strain, impact, pressure and fracture. The present invention is a new and more efficient process for synthesizing and testing triboluminescent and photoluminescent materials.

专利号:US-10844088-B2
优先权日:2011-07-19
标 题:Process for the preparation of estetrol
发明人:PLATTEEUW JOHANNES JAN; COELINGH BENNINK HERMAN JAN TIJMEN; DAMEN FRANCISCUS WILHELMUS PETRUS; VAN VLIET MICHIEL CHRISTIAN ALEXANDER
权利人:DONESTA BIOSCIENCE B V; ESTETRA SPRL
摘要:The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3, 15a, 16a, 17β-tetraol (estetr-01), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10), 16-tetraene, wherein A is a protecting group and B is —Si(R 2 ) 3 . The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10), 15-tetraen-17-one, in which A is a protecting group, via silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, and B is —Si(R 2 ) 3 .

专利号:US-7902196-B2
优先权日:2005-03-17
标 题 :Synthesis of avrainvillamide, strephacidin B, and analogues thereof
发明人:MYERS ANDREW G; HERZON SETH B; WULFF JEREMY EARLE; SIEGRIST ROMAIN; SVENDA JAKUB; ZAJAC MATTHEW ALLEN
权利人:HARVARD COLLEGE
摘要:The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

专利号:US-7105637-B2
优先权日:2002-02-15
标题 :Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis
发明人:SHACKLETON CEDRIC; GUO LI-WEI; WILSON WILLIAM K
权利人:CHILDRENS HOSP & RES CT OAK
摘要:The invention provides isolated dehydro-estriol (8-DHE 3 ) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS).

专利号:US-2009143581-A1
优先权日:2005-03-17
标题 :Synthesis of avrainvillamide, strephacidin b, and analogues thereof

专利号:CA-2601135-A1
优先权日:2005-03-17
标 题 :Synthesis of avrainvillamide, stephacidin b, and analogues thereof
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合成参考文献


摘要:Nakao, Y., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 367.
摘要:J. N. Gardner and A. R. Katritzky. J. Chem. Soc. 1957, 4375.
摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 265.
摘要:Jha, N.; Kapur, M., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 104.
摘要:Adak, L.; Ghosh, T.; Ranu, B. C., Science of Synthesis: Cross-Dehydrogenative Coupling, (2023) nan, 426.
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