CAS: 104774-87-0; 3-(3-(Trifluoromethyl)Phenyl)Propan-1-Amine

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CAS号535-53-5 3-(3-(trifluoro... | CAS号60689-14-7 3-[3-(trifluoro... | CAS号64380-24-1 3-(trifluoromet... | CAS号93040-58-5 3-(3-(trifluoro... | CAS号779-89-5 间三氟甲基肉桂酸

📜3-三氟甲基苯甲醛置于硼烷四氢呋喃络合物,Palladium 10% On Activated Carbon,氢气,Sodium Hydride体系中,用 四氢呋喃,甲醇 用作溶剂,20.0~60.0 °C,202.66 Kpa 条件下,反应 3.5H,反应生成3-[3-(三氟甲基)苯基]-1-丙胺
参考文献:8-Hydroxyquinolin-2(1H)-One 类似物作为潜在的 β2-激动剂:设计,合成和活性研究
标题:8-Hydroxyquinolin-2(1H)-One 类似物作为潜在的 β2-激动剂:设计,合成和活性研究
摘要:与导致 Camp 积累的质膜β 2-肾上腺素受体结合的β 2-激动剂被广泛用作慢性呼吸系统疾病中的支气管扩张剂.在这里,我们设计并合成了一组 8-Hydroxyquinolin-2(1 H )-One 类似物,并通过细胞 Camp 测定研究了它们的 β 2-激动活性.在测试的化合物中,化合物b05和c08被确定为有效的 (Ec 50 < 20 Pm) 和选择性 β 2-激动剂.它们表现为部分 β 2β-激动剂在非过表达的 Hek293 细胞中,并在离体豚鼠气管条制剂中具有快速平滑肌松弛作用和长作用持续时间.综上所述,B05和c08是具有潜在适用于慢性呼吸道疾病的 β 2-激动剂.
Doi:10.1016/j.Ejmech.2021.113697

专利信息

专利号:US-8614354-B2
优先权日:2008-06-18
标题 :Process for the synthesis of cinacalcet hydrochloride
发明人：FERRARI MASSIMO; GHEZZI MARCELLO; BONALDI MATTEO
权利人:FERRARI MASSIMO; GHEZZI MARCELLO; BONALDI MATTEO; ERREGIERRE SPA
摘要:There is described a process for the preparation of cinacalcet hydrochloride (I) which includes the steps of: a) reacting (R)-(+)-1-(1-naphthyl)ethylamine (II) with 3-[3-(trifluoromethyl)phenyl]propenaldehyde (III) to afford the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[1-(1-naphthyl)ethylamine (IV); b) reducing the non isolated intermediate (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenylimino-N-[-1-(1-naphthyl)ethylamine (IV) with a sequential addition of:—a solution of sodium borohydride, methanol and a base,—oxalic acid and—a base to obtain (R)—N-[3-[3-(tifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) by passing through the precipitation of the oxalate salt of compound (V) after the addition of oxalic acid; c) hydrogenating (R)—N-[3-[3-(trifluoromethyl)phenyl]-2-propenyl]-1-(1-naphthyl)ethylamine (V) thus obtaining (R)—N-(3-(3-(trifluoromethyl)phenyl]propyl]-1-(1-naphthyl)ethylamine cinacalcet base (VI), which is retaken in ethyl acetate; and d) treating the solution of cinacalcet base (VI) in ethyl acetate with hydrochloric acid to afford cinacalcet hydrochloride (I).

专利号:EP-1990333-A1
优先权日:2007-05-11
标题 :Process for the preparation of cinacalcet hydrochloride
权利人:SANDOZ AG
摘要:The present invention relates to a process for the preparation of cinacalcet hydrochloride which is industrially feasible and commercially viable. The synthesis of cinacalcet hydrochloride is carried out by the condensation of 3-trifluromethylphenyl propionic acid with R-(+)-1-(lnaphthyl)ethylamine.

专利号:US-7361789-B1
优先权日:2004-07-28
标 题 :Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
发明人：YAN QI; ORIHUELA CARLOS; SHEN BO; CHEN YING; WANG XIN; NG JOHN; JI RUIZHI; ZHOU PENGZU
权利人:AMGEN INC
摘要:The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.

专利号:US-2008319229-A1
优先权日:2007-06-22
标题 :process for the preparation of cinacalcet
发明人：ALLEGRINI PIETRO; ATTOLINO EMANUELE
权利人:DIPHARMA FRANCIS SRL
摘要:The invention provides a novel process for the preparation of a compound of formula (I) n n n n n n n n n n n n which includes the reduction of a compound of formula (II) or a salt thereof, in the presence of a catalyst, n n n n n n n n n n n n n n n n and novel intermediates useful for its synthesis.

专利号:US-2011105799-A1
优先权日:2008-06-18
标 题 :process for the synthesis of cinacalcet hydrochloride

专利号:EP-2321256-A1
优先权日:2008-06-18
标 题:A process for the synthesis of cinacalcet hydrochloride