CAS: 940-69-2; 5-(1,2-Dithiolan-3-yl)Pentanamide

该化合物是一种生物化学化合物,其特征是作为各种酶反应的共生体,特别是碳水化合物和脂肪酸的代谢物;它是脂酸的衍生物,其成分为氨化功能组,其成分为增强溶解性和再活性;利波阿米德以其抗氧化特性而著称,有助于中和自由基质,保护细胞免受氧化压力;在激素脱氢酶和甲酸甲基甲酸脱氢酶复合体中发挥着关键作用,促进将气压酸酯转化为乙酰胺-CoA和甲酸酯脱色体,该化合物通常存在于细胞的离子体分泌,对能源生产至关重要;此外,利波阿米德可以参与红氧化反应,正在发生可逆转的氧化和减少,这对其代谢途径的作用至关重要. 其化学化学文学编号为940-69-2, 其化学化学研究数据库和化学化学化学研究应用中确认其独特的用途.

结构式图片

相似化合物

1077-27-6 1077-28-7 1200-22-2

物理性质

MSDS等安全信息

欧盟法规

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上下游产品

CAS号40846-94-4 α-Lipoic acid-NHS | CAS号3884-47-7 6,8-bis-sulfany... | CAS号1077-28-7 硫辛酸 | CAS号53-84-9 辅酶I | CAS号3884-47-7 6,8-bis-sulfany... | CAS号89-71-4 邻甲基苯甲酸甲酯 | CAS号629-01-6 正辛酰胺

合成工艺路线路线简述

  • 1182844-31-0 = 940-69-2
    反应条件:1.1 Reagents: Ammonia Solvents: Ethanol,Tetrahydrofuran,Water; 3 H,25 - 30 °C
    标题:Synthesis And Characterization Of Lipoamide
    作者:Hu,Yumei; Xiong,Liang; Huang,Tao; Liu,Haowen; Liu,Huiling
    参考文献:Zhongnan Minzu Daxue Xuebao 日期:2008 卷标:27(4) 页码:13-15]

    1077-28-7 = 940-69-2
    反应条件:1.1 Reagents: Ethyl Chloroformate Catalysts: Triethylamine Solvents: Chloroform; Cooled; 5 °C; < 5 °C; 1 - 1.5 H,2 - 7 °C; 10 Min,2 - 7 °C1.2 Reagents: Ammonia; 1 - 1.5 H1.3 Solvents: Chloroform; 0.5 H,Reflux; Reflux -> 45 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; 45 °C; 10 Min,45 °C1.5 Reagents: Sodium Hydroxide Solvents: Water
    标题:Process For Preparation Of Lipoamides From Lipoic Acids
    参考文献:China]

    1070-64-0 = 940-69-2
    反应条件:1.1 Reagents: Formamide Catalysts: Sodium Methoxide Solvents: Tetrahydrofuran1.2 Reagents: Disodium Sulfide,Sulfur Solvents: Ethanol
    标题:Synthesis Of Thioctamide
    参考文献:China]

    = 940-69-2 [标题:Reaction Conditions
    标题:Transport System Conjugate
    参考文献:World Intellectual Property Organization]

    = 940-69-2 [标题:Reaction Conditions
    标题:Lipoic Acid Amide
    参考文献:Ussr]

    = 940-69-2 [标题:Reaction Conditions
    标题:α-Lipoic Acid Amide
    参考文献:Ussr]

    = 940-69-2 [标题:Reaction Conditions
    标题:6,8-Dithiooctanoyl Halide
    参考文献:Japan]

    40846-94-4 = 940-69-2
    反应条件:1.1 Reagents: Ammonia Solvents: Chloroform,Acetonitrile,Water; 1 H,Rt
    标题:Synthesis Of A New Family Of Protected 1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid Derivatives With Thioctic Acid Pending Arms
    作者:De La Reberdiere,Arnaud; Lachaud,Fabien; Chuburu,Francoise; Cadiou,Cyril; Lemercier,Gilles
    参考文献:Tetrahedron Letters 日期:2012 卷标:53(45) 页码:6115-6118]

    1200-22-2 = 940-69-2
    反应条件:1.1 Reagents: Ammonium Hydroxide Catalysts: Lipase Calb (Candida Antarctica) Solvents: 1,4-Dioxane; 3 D,Rt -> 50 °C
    标题:Lipase-Catalyzed Amidation Of Carboxylic Acid And Amines
    作者:Manova,Daniela; Gallier,Florian; Tak-Tak,Lotfi; Yotava,Lyubov; Lubin-Germain,Nadege
    参考文献:Tetrahedron Letters 日期:2018 卷标:59(21) 页码:2086-2090]

    95355-61-6 = 940-69-2
    反应条件:1.1 Reagents: Ammonium Hydroxide Solvents: Tetrahydrofuran,Water; 1 H,-25 - -10 °C; 1 H,-10 °C -> Rt
    标题:Interaction Of α-Lipoic Acid With The Human Na+/multivitamin Transporter (Hsmvt)
    作者:Zehnpfennig,Britta; Wiriyasermkul,Pattama; Carlson,David A.; Quick,Matthias
    参考文献:Journal Of Biological Chemistry 日期:2015 卷标:290(26) 页码:16372-16382]

    = 940-69-2 [标题:Reaction Conditions
    标题:Preparation Method Of Lipoic Acid Derivative And Its Application
    参考文献:China]

    = 940-69-2 [标题:Reaction Conditions
    标题:Characterization Of Organic Molecules Attached To Gold Nanoparticle Surface Using High Resolution Magic Angle Spinning 1H Nmr
    作者:Zhou,Hongyu; Du,Fenfang; Li,Xi; Zhang,Bin; Li,Wei; Et Al
    参考文献:Journal Of Physical Chemistry C 日期:2008 卷标:112(49) 页码:19360-19366]

    = 940-69-2 [标题:Reaction Conditions
    标题:Oxidation Of Dithiols By 10-Thiaisoalloxazine
    作者:Sako,Magoichi; Kojima,Yutaka; Hirota,Kosaku; Maki,Yoshifumi
    参考文献:Heterocycles 日期:1984 卷标:22(5) 页码:1017-20]

    = 940-69-2 [标题:Reaction Conditions
    标题:Improvement Of The Synthesis Of Lipoic Acid Amide
    作者:Tursin,V. M.; Chebotareva,L. G.; Yurkevich,A. M.
    参考文献:Khimiko-Farmatsevticheskii Zhurnal 日期:1975 卷标:9(12) 页码:26-7]

    = 940-69-2 [标题:Reaction Conditions
    标题:1,2-Dithiolane-3-Valeramide
    参考文献:Japan
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于1,4-二氧六环,氨体系中,化学反应生成 (+/-)-Alpha-硫辛酰胺
参考文献:Properties And Derivatives Of α-Lipoic Acid
标题:Properties And Derivatives Of α-Lipoic Acid
摘要:
DOI:10.1021/ja01600A069

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主要参考文献


1: Bryk R, Arango N, Maksymiuk C, Balakrishnan A, Wu YT, Wong CH, Masquelin T, Hipskind P, Lima CD, Nathan C. Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 2013 Dec 23;52(51):9375-84. doi: 10.1021/bi401077f. Epub 2013 Nov 26.
2: Zhao L, Liu Z, Jia H, Feng Z, Liu J, Li X. Lipoamide Acts as an Indirect Antioxidant by Simultaneously Stimulating Mitochondrial Biogenesis and Phase II Antioxidant Enzyme Systems in ARPE-19 Cells. PLoS One. 2015 Jun 1;10(6):e0128502. doi: 10.1371/journal.pone.0128502. eCollection 2015.
3: Chen W, Taylor NL, Chi Y, Millar AH, Lambers H, Finnegan PM. The metabolic acclimation of Arabidopsis thaliana to arsenate is sensitized by the loss of mitochondrial LIPOAMIDE DEHYDROGENASE2, a key enzyme in oxidative metabolism. Plant Cell Environ. 2014 Mar;37(3):684-95. doi: 10.1111/pce.12187. Epub 2013 Nov 11. doi: 10.1111/j.1476-5381.2010.01134.x.

合成参考文献

参考DOI号:10.1016/j.tetlet.2012.08.150
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