CAS: 923-16-0; (R)-2-((R)-2-Aminopropanamido)Propanoic Acid
- 英文名称(R)-2-((R)-2-Aminopropanamido)Propanoic Acid
- 中文名称D-丙氨酰-D-丙氨酸
- IUPAC名称D-alanyl-D-alanine
- 其它别名2-[[(2R)-2-Aminopropanoyl]Amino]Propanoic Acid; D-Alanyl-D-Alanine; H-D-Ala-D-Ala-Oh; (D-Ala)2; (R)-2-((R)-2-Aminopropanamido)Prop
- CAS编号923-16-0
- MFCD编号:MFCD00066038
- FDA UNII编号:1BVK9QMW8G
- 分子式:C6H12N2O3
- 分子量:160.17
- 产品CID: 1960846
- 产品分类有机原料→生命科学→氨基酸及其衍生物→丙氨酸及其衍生物
相似化合物
1948-31-8 2867-20-1 27317-69-7物理性质
MSDS等安全信息
上下游产品
CAS号1114-94-9 D-丙氨酰-L-丙氨酰-D-丙氨酸 | CAS号338-69-2 D-丙氨酸合成工艺路线路线简述
- 合成目标产物 D-Alanyl-D-Alanine 主要起始原料 Ethanamine, N-[(3,5-Dichlorophenyl)Methylene]-2,2-Diethoxy-
- 620964-45-6 = 923-16-0
反应条件:1.1 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt
标题:Solid-Phase Synthesis Of Fluorescent Analogues Of Park'S Nucleotide,Lipid I And Lipid Ii
作者:Katsuyama,Akira; Yakushiji,Fumika; Ichikawa,Satoshi
参考文献:Tetrahedron Letters 日期:2021 卷标:73]
= 923-16-0 [标题:Reaction Conditions
标题:Binding Properties Of Antimicrobial Agents To Dipeptide Terminal Of Lipid Ii Using Surface Plasmon Resonance
作者:Kinouchi,Hiroki; Arimoto,Hirokazu; Nishiguchi,Kenzo; Oka,Masako; Maki,Hideki; Et Al
参考文献:Analytical Biochemistry 日期:2014 卷标:452 页码:67-75]
= 923-16-0 [标题:Reaction Conditions
标题:Structural Requirements For The Substrates Of The H+/peptide Cotransporter Pept2 Determined By Three-Dimensional Quantitative Structure-Activity Relationship Analysis
作者:Biegel,Annegret; Gebauer,Sabine; Brandsch,Matthias; Neubert,Klaus; Thondorf,Iris
参考文献:Journal Of Medicinal Chemistry 日期:2006 卷标:49(14) 页码:4286-4296]
= 923-16-0 [标题:Reaction Conditions
标题:Separation Of Stereoisomers Of Polypeptides By Chromatography
参考文献:Japan]
= 923-16-0 [标题:Reaction Conditions
标题:Chromophoric Peptides,An Agent Containing Them And Their Use For Detection Of Dd-Carboxypeptidases
参考文献:Federal Republic Of Germany]
5845-61-4 + 35590-65-9 = 923-16-0 + 3695-80-5 + 1115-78-2 + 1948-31-8
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 25 °C
标题:Epimerization Of Cyclic Alanyl-Alanine In Basic Solutions
作者:Munegumi,Toratane; Fujimoto,Takeshi; Michiotakada; Nozominagashima
参考文献:Oriental Journal Of Chemistry 日期:2014 卷标:30(1) 页码:23-30]
56-41-7 = 923-16-0 + 3695-80-5 + 1115-78-2 + 1948-31-8
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Water; 1 D,Ph 2.5,120 °C
标题:Method For Preparing Chiral Amino Acid Dipeptides By Controlling Reaction Time
参考文献:China]
338-69-2 = 923-16-0
反应条件:1.1 Catalysts: D-Alanine:D-Alanine Ligase (A)
标题:The Biological Properties And Potential Interacting Proteins Of D-Alanyl-D-Alanine Ligase A From Mycobacterium Tuberculosis
作者:Yang,Shufeng; Xu,Yuefei; Wang,Yan; Ren,Feng; Li,Sheng; Et Al
参考文献:Molecules 日期:2018 卷标:23(2)]
338-69-2 = 923-16-0
反应条件:1.1 Reagents: Potassium Chloride,Magnesium Chloride,Ammonium Chloride Solvents: Water; 0.16 - 16 H,Ph 7 - 9,30 - 70 °C1.2 Reagents: D-Alanine
标题:Engineering An Atp-Dependent D-Ala:D-Ala Ligase For Synthesizing Amino Acid Amides From Amino Acids
作者:Miki,Yuta; Okazaki,Seiji; Asano,Yasuhisa
参考文献:Journal Of Industrial Microbiology & Biotechnology 日期:2017 卷标:44(4-5) 页码:667-675]
338-69-2 = 923-16-0
反应条件:1.1 Reagents: 5′-Atp,Sulfuric Acid Magnesium Salt (1:1) Catalysts: Synthetase,D-Alanylalanine (Escherichia Coli Strain K-12 Gene Ddlb); 7 H,37 °C
标题:D-Amino Acid Dipeptide Production Utilizing D-Alanine-D-Alanine Ligases With Novel Substrate Specificity
作者:Sato,Masaru; Kirimura,Kohtaro; Kino,Kuniki
参考文献:Journal Of Bioscience And Bioengineering 日期:2005 卷标:99(6) 页码:623-628]
79990-15-1 = 923-16-0
反应条件:1.1 Reagents: Piperidine Solvents: Dimethylformamide1.2 Reagents: 1-Hydroxybenzotriazole,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: 4-Methylmorpholine; 1 H,Rt1.3 Reagents: Piperidine Solvents: Dimethylformamide1.4 Reagents: Trifluoroacetic Acid,Triisopropylsilane Solvents: Water
标题:Three-Dimensional Quantitative Structure-Activity Relationship Analyses Of β-Lactam Antibiotics And Tripeptides As Substrates Of The Mammalian H+/peptide Cotransporter Pept1
作者:Biegel,Annegret; Gebauer,Sabine; Hartrodt,Bianka; Brandsch,Matthias; Neubert,Klaus; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2005 卷标:48(13) 页码:4410-4419]
= 923-16-0
反应条件:1.1 Reagents: Water Solvents: Water
标题:Stereoselective Alkylation Of Glycine Units In Dipeptide Derivatives. "Chirality Transfer" Via A Pivalaldehyde N,N-Acetal Center
作者:Polt,Robin; Seebach,Dieter
参考文献:Journal Of The American Chemical Society 日期:1989 卷标:111(7) 页码:2622-32]
= 923-16-0
反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium1.2 Reagents: Hydrochloric Acid Solvents: Water
标题:Alkylation Of Imidazolidinone Dipeptide Derivatives: Preparation Of Enantiomerically Pure Di- And Tripeptides By 'Chirality Transfer' Via A Pivalaldehyde N,N-Acetal Center
作者:Polt,Robin; Seebach,Dieter
参考文献:Helvetica Chimica Acta 日期:1987 卷标:70(7) 页码:1930-6]
= 923-16-0 [标题:Reaction Conditions
标题:Discovery Of A Fragment Hit Compound Targeting D-Ala:D-Ala Ligase Of Bacterial Peptidoglycan Biosynthesis
作者:Proj,Matic; Hrast,Martina; Bajc,Gregor; Frlan,Rok; Meden,Anze; Et Al
参考文献:Journal Of Enzyme Inhibition And Medicinal Chemistry 日期:2023 卷标:38(1) 页码:387-397]
= 923-16-0 [标题:Reaction Conditions
标题:Antibacterial Peptides
参考文献:World Intellectual Property Organization]
56-41-7 = 923-16-0 + 3695-80-5 + 1115-78-2 + 1948-31-8
反应条件:1.1 60 S,< 1.0E-4 Pa,290 K
标题:Quantum Yields Of Decomposition And Homo-Dimerization Of Solid L-Alanine Induced By 7.2 Ev Vacuum Ultraviolet Light Irradiation: An Estimate Of The Half-Life Of L-Alanine On The Surface Of Space Objects
作者:Izumi,Yudai; Nakagawa,Kazumichi
参考文献:Origins Of Life And Evolution Of Biospheres 日期:2011 卷标:41(4) 页码:385-395
(+)-1-(Benzyloxycarbonyl)-2(R)-Tert-Butyl-3-<(R)Methyl(Methoxycarbonyl)Methyl>-5(R)-Methylimidazolidin-4-One置于palladium On Activated Charcoal Potassium Trimethylsilonate,水,氢气体系中,用 四氢呋喃,乙酸乙酯 作为反应溶剂,化学反应 3.08H,反应生成 D-丙氨酰-D-丙氨酸
参考文献:Stereoselective Alkylation Of Glycine Units In Dipeptide Derivatives. "Chirality Transfer" Via A Pivalaldehyde N,N-Acetal Center
标题:Stereoselective Alkylation Of Glycine Units In Dipeptide Derivatives. "Chirality Transfer" Via A Pivalaldehyde N,N-Acetal Center
摘要:
DOI:10.1021/ja00189A042
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专利信息
专利号:WO-2009056901-A1
优先权日:2007-10-31
标题:Cyclodipeptide synthases (cdss) and their use in the synthesis of linear dipeptides
专利号:US-2011015119-A1
优先权日:2009-06-24
标题:Novel semi-synthetic glycopeptides as antibacterial agents
发明人：CHU DANIEL; YE TAO; WANG BING
权利人:LEAD THERAPEUTICS INC
摘要:Semi-synthetic glycopeptides having antibacterial activity are described, in particular, the semi-synthetic glycopeptides described herein are made by chemical modification of a glycopeptide (Compound A, Compound B, Compound H or Compound C) or monosaccharide made by hydrolyzing the disaccharide moiety of the amino acid-4 of the parent glycopeptide in acidic medium to give the amino acid-4 monosaccharide; conversion of the monosaccharide to the amino-sugar derivative; acylation of the amino substituent on the amino acid-4 amino-substituted sugar moiety on these scaffolds with certain acyl groups; and conversion of the acid moiety on the macrocyclic ring of these scaffolds to certain substituted amides. Key reaction is the treatment of properly protected intermediate compound with isocyanate. Also provided are methods for the synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.
专利号:US-6977141-B2
优先权日:1998-02-10
标 题 :Direct adsorption scintillation assay for measuring enzyme activity and assaying biochemical processes
发明人：YUAN ZHENGYU; CHEN ZHONG-XIAO
权利人:VICURON PHARM INC
摘要:Methods and materials for scintillation assays are disclosed. The scintillation assays rely on differences in general molecular property-based binding interactions, such as charge or hydrophobicity, to localize a radioactive substance near a scintillating material, stimulating scintillation. They are thus described as a direct adsorption scintillation assay (DASA) to distinguish them from the scintillation proximity assay (SPA). The assays are more convenient and inexpensive to implement than SPAs, which rely on specific binding of ligand-receptor pairs, antibody-antigen pairs, or other binding partners which rely on the precise and specific structural complementarity of the partners. The assays can be employed for studying enzymatic reactions, such as those involved in the synthesis of Mur-pentapeptide. The assays are readily adaptable to high throughput screening for use in conjunction with combinatorial libraries of compounds.
专利号:WO-0170937-A1
优先权日:2000-03-24
标 题:A new thermostable d-stereospecific dipeptidase from brevibacillus bostelensis bcs-1 and its use as a biocatalyst for the synthesis of peptides containing d-amino acids
专利号:US-7169919-B2
优先权日:2000-04-18
标题:Process for preparing lipid II
发明人：ALBORN JR WILLIAM ERNEST; BLASZCZAK LARRY CHRIS; MAULDIN SCOTT CARL; SKATRUD PAUL LUTHER; VANNIEUWENHZE MICHAEL SCOTT; ZIA-EBRAHIMI MOHAMMAD SADEGH
权利人:LILLY CO ELI
摘要:A process is described for preparing a substrate for the transglycosylase enzymes of bacterial cell wall biosynthesis. The chemical synthesis makes available a sustainable and substantially pure source of supply of lipid II, including analogs thereof, that may be used in the identification of new therapeutic agents capable of disrupting steps in bacterial cell wall biosynthesis.
专利号:US-10934326-B2
优先权日:2016-10-31
标 题:Peripheral modifications on pocket-redesigned vancomycin analogs synergistically improve antimicrobial potency and durability
发明人：BOGER DALE
权利人:SCRIPPS RESEARCH INST
摘要:A C-terminus modification to a binding pocket-modified vancomycin introduces a quaternary ammonium salt that provides a binding pocket-modified vancomycin analog with a second mechanism of action that is independent of D-Ala-D-Ala/D-Ala-D-Lac binding. The modification disrupts cell wall integrity and induces cell wall permeability complementary to the glycopeptide inhibition of cell wall synthesis, and provides synergistic improvements in antimicrobial potency (200-fold) against vancomycin-resistant bacteria. Combining the C-terminus and binding pocket modifications with an orthogonal (4-chlorobiphenyl) methyl addition to the vancomycin disaccharide provides even more potent antimicrobial agents whose activity can be attributed to three independent and synergistic mechanisms of action, only one of which requires D-Ala-D-Ala/D-Ala-D-Lac binding. The resulting modified vancomycins display little propensity for acquired resistance through serial exposure of vancomycin-resistant Enterococci and their durability against such challenges as well as their antimicrobial potency follow predicable trends. Methods of treatment with and compositions containing the modified vancomycins are disclosed.
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主要参考文献
参考标题:Harnessing Chemical Energy For The Activation And Joining Of Prebiotic Building Blocks作者:Ziwei Liu,Long-Fei Wu,Jianfeng Xu,Claudia Bonfio,David A. Russell,John D. Sutherland |发布日期:2020.11
摘要:Harnessed To Activate Nucleoside Phosphates And Carboxylic Acids Through Catalysis By Acid And 4,5-Dicyanoimidazole Under Mild Aqueous Conditions. Simultaneous Activation Of Carboxylates And Phosphates Provides Multiple Pathways For The Generation Of Reactive Intermediates, Including Mixed Carboxylic Acid-Phosphoric Acid Anhydrides, For The Synthesis Of Peptidyl-Rnas, Peptides, Rna Oligomers And Primordial
合成参考文献
参考文献:10.1186/1471-2164-15-349
摘要:Sánchez-Rodríguez A, Tytgat HL, Winderickx J, Vanderleyden J, Lebeer S, Marchal K. A network-based approach to identify substrate classes of bacterial glycosyltransferases. BMC Genomics. 2014 May 08;15():349.
参考文献:10.1007/s00705-015-2631-8
摘要:Dyson ZA, Tucci J, Seviour RJ, Petrovski S. Isolation and characterization of bacteriophage SPI1, which infects the activated-sludge-foaming bacterium Skermania piniformis. Arch Virol. 2016 Jan;161(1):149–58. doi: 10.1007/s00705-015-2631-8.
参考文献:10.3201/eid1007.030993
摘要:Tambyah PA, Marx JA, Maki DG. Nosocomial infection with vancomycin-dependent enterococci. Emerg Infect Dis. 2004 Jul;10(7):1277–81.
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