CAS: 84311-18-2; (R)-2-((Tert-Butoxycarbonyl)Amino)-3-Hydroxy-2-Methylpropanoic Acid

• 英文名称(R)-2-((Tert-Butoxycarbonyl)Amino)-3-Hydroxy-2-Methylpropanoic Acid
• 中文名称(R)-2-((叔丁氧基羰基)氨基)-3-羟基-2-甲基丙酸
• IUPAC名称(R)-2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid
• 其它别名(R)-2-((叔丁氧羰基)氨基)-3-羟基-2-甲基丙酸; N-Boc-α-Methyl-D-Serine
• CAS编号84311-18-2
• MFCD编号:MFCD02682596
• 分子式:C9H17NO5
• 分子量:219.24
• 产品CID: 1831696
• 产品分类有机原料→分子砌块→手性化合物→手性砌块

• 相似结构搜索
• InChIKey: FWRXDSRYWWYTPD-SECBINFHSA-N
• InChI=1S/C9H17NO5/c1-8(2,3)15-7(14)10-9(4,5-11)6(12)13/h11H,5H2,1-4H3,(H,10,14)(H,12,13)/t9-/m1/s1…
• 计算化学: 氢键受体数4.0氢键供体数3.0可旋转键数3.0

相似化合物

物理性质

• 熔点115-117 °C
• 沸点387.1±37.0 °C at 760 mmHg
• 闪点187.9±26.5 °C
• 密度1.2±0.1 g/cm3
• PSA:95.86
• LogP:0.3467
• 折射率1.486
• 蒸汽压0.0±2.0 mmHg at 25°C
• 储存条件2-8°C

MSDS等安全信息

• GHS符号GHS07
• 警示词Warning
• 危险描述H302-H315-H319-H335
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
• 危险等级IRRITANT

上下游产品

合成工艺路线路线简述

• 24424-99-5 + 81132-44-7 = 84311-18-2
  反应条件:1.1 Reagents: Triethylamine,Sodium Hydroxide Solvents: Methanol,Water; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 2,Rt
  标题:Synthesis,Radiolabeling,And Biological Evaluation Of (R)- And (S)-2-Amino-3-[18F]Fluoro-2-Methylpropanoic Acid (Famp) And (R)- And (S)-3-[18F]Fluoro-2-Methyl-2-N-(Methylamino)Propanoic Acid (Nmefamp) As Potential Pet Radioligands For Imaging Brain Tumors
  作者:Yu,Weiping; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2010 卷标:53(2) 页码:876-886]
  
  356048-04-9 = 84311-18-2
  反应条件:1.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; 10 Min,Rt1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,Rt2.1 Solvents: 1,4-Dioxane; Overnight,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037]
  
  356048-02-7 = 84311-18-2
  反应条件:1.1 Reagents: Sodium Azide Solvents: Dimethylformamide; Rt -> 50 °C; 2 D,50 °C2.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; 10 Min,Rt2.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,Rt3.1 Solvents: 1,4-Dioxane; Overnight,Rt3.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037]
  
  24424-99-5 + 81132-44-7 = 84311-18-2
  反应条件:1.1 Solvents: 1,4-Dioxane; Overnight,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037]
  
  24424-99-5 + 81132-44-7 = 84311-18-2
  反应条件:1.1 Reagents: Triethylamine,Sodium Hydroxide Solvents: Methanol,Water; Rt1.2 Overnight,Rt
  标题:Facile Stereospecific Synthesis And Biological Evaluation Of (S)- And (R)-2-Amino-2-Methyl-4-[123I]Iodo-3-(E)-Butenoic Acid For Brain Tumor Imaging With Single Photon Emission Computerized Tomography
  作者:Yu,Weiping; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2007 卷标:50(26) 页码:6718-6721]
  
  147501-85-7 = 84311-18-2
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Carbon Tetrachloride; Overnight,Reflux2.1 Reagents: Sodium Azide Solvents: Dimethylformamide; Rt -> 50 °C; 2 D,50 °C3.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; 10 Min,Rt3.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,Rt4.1 Solvents: 1,4-Dioxane; Overnight,Rt4.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037]
  
  149099-00-3 = 84311-18-2
  反应条件:1.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 5 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 21.3 Reagents: Acetyl Chloride; 0 °C; Overnight,Reflux2.1 Reagents: Thionyl Chloride Solvents: Carbon Tetrachloride; Overnight,Reflux3.1 Reagents: Sodium Azide Solvents: Dimethylformamide; Rt -> 50 °C; 2 D,50 °C4.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; 10 Min,Rt4.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,Rt5.1 Solvents: 1,4-Dioxane; Overnight,Rt5.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037]
  
  132960-14-6 = 84311-18-2
  反应条件:1.1 Reagents: Potassium Carbonate,Methanesulfonamide,Potassium Osmate Dihydrate,Potassium Ferricyanide,1,4-Bis(9-O-Dihydroquinidinyl)Phthalazine,Ad-Mix-β Solvents: Tert-Butanol,Water; Rt -> 0 °C; 6 H,0 °C; Overnight,0 °C -> Rt1.2 Reagents: Sodium Sulfite Solvents: Water; 30 Min,0 °C2.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 5 H,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 22.3 Reagents: Acetyl Chloride; 0 °C; Overnight,Reflux3.1 Reagents: Thionyl Chloride Solvents: Carbon Tetrachloride; Overnight,Reflux4.1 Reagents: Sodium Azide Solvents: Dimethylformamide; Rt -> 50 °C; 2 D,50 °C5.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; 10 Min,Rt5.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,Rt6.1 Solvents: 1,4-Dioxane; Overnight,Rt6.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037]
  
  1117-97-1 = 84311-18-2
  反应条件:1.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 1 H,Reflux1.2 Reagents: Pyridine; Reflux -> 0 °C; Overnight,Rt2.1 Reagents: Potassium Carbonate,Methanesulfonamide,Potassium Osmate Dihydrate,Potassium Ferricyanide,1,4-Bis(9-O-Dihydroquinidinyl)Phthalazine,Ad-Mix-β Solvents: Tert-Butanol,Water; Rt -> 0 °C; 6 H,0 °C; Overnight,0 °C -> Rt2.2 Reagents: Sodium Sulfite Solvents: Water; 30 Min,0 °C3.1 Reagents: Lithium Hydroxide Solvents: Methanol,Water; 5 H,Rt3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1 - 23.3 Reagents: Acetyl Chloride; 0 °C; Overnight,Reflux4.1 Reagents: Thionyl Chloride Solvents: Carbon Tetrachloride; Overnight,Reflux5.1 Reagents: Sodium Azide Solvents: Dimethylformamide; Rt -> 50 °C; 2 D,50 °C6.1 Reagents: Potassium Hydroxide Solvents: Methanol,Water; 10 Min,Rt6.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol; Overnight,Rt7.1 Solvents: 1,4-Dioxane; Overnight,Rt7.2 Reagents: Hydrochloric Acid Solvents: Water
  标题:Enantioselective Synthesis Of α-Methyl-D-Cysteine And Lanthionine Building Blocks Via α-Methyl-D-Serine-β-Lactone
  作者:Smith,Nicole D.; Et Al
  参考文献:Organic Letters 日期:2003 卷标:5(7) 页码:1035-1037

海关参考信息

• 2905122000-异丙醇
  2905143000-叔丁醇
  2905399001-1,3-丙二醇
  2912110000-甲醛
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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