CAS: 79559-97-0; Sertraline Hydrochloride

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CAS号79617-96-2 舍曲林 | CAS号244223-89-0 (cis-1S)-4-(3,4... | CAS号836597-67-2 (1S-cis)-4-(3,4... | CAS号64-19-7 冰醋酸 | CAS号254731-40-3 1S-cis-4-(3,4-d... | CAS号79617-96-2 舍曲林

邻二氯苯置于盐酸,Aluminum (Iii) Chloride,硼烷-N,N-二乙基苯胺,水,氢气,Sodium Hydride,Sodium Carbonate,Sodium Sulfite,(R)-2-甲基-Cbs-恶唑硼烷体系中,用 四氢呋喃,甲醇,乙醚,正己烷,二氯甲烷,水,乙酸乙酯,N,N-二甲基甲酰胺,甲苯,Mineral Oil 作为反应溶剂,化学反应 65.83H,反应生成 盐酸舍曲林
参考文献:使用氯磺酰基异氰酸酯的手性苯甲醚的立体选择性胺化:(+)-舍曲林的全合成
标题:使用氯磺酰基异氰酸酯的手性苯甲醚的立体选择性胺化:(+)-舍曲林的全合成
摘要:已开发出使用氯磺酰基异氰酸酯对各种手性苄基醚进行立体选择性胺化的方法,还描述了该方法在从容易获得的1-萘酚全合成强效抗抑郁药(+)-舍曲林中的应用.
DOI:10.1021/jo201794K

专利信息

专利号:US-10266481-B2
优先权日:2014-06-20
标题:Organocatalytic asymmetric synthesis of antidepressants
发明人：VAITHIYANATHAN VENKATARAMASUBRAMANIAN; KALSHETTI RUPALI GUNDAPPA; ARUMUGAM SUDALAI
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a short enantioselective synthesis of 1-amino aryl tetraline compounds of Formula 1 via nucleophilic enamine catalysis using organocatalyst such as proline. n n n n n n n n n n n n wherein R 1 and R 2 represent independent of each other hydrogen, (un)substituted or substituted amine; n R 3 and R 4 represent independent of each other hydrogen or halogen.

专利号:US-2006030625-A1
优先权日:2004-08-06
标 题 :Dietary neurotransmitter precursors for balanced synthesis of neurotransmitters
发明人：HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
权利人:HART CHERYLE RAM; GROSSMAN RONALD S; RAM HERBERT
摘要:Dietary supplements for treating a neurotransmitter deficiency include one or more precursors of the deficient neurotransmitter and a cofactor for activating in vivo enzymatic synthesis of the deficient neurotransmitter. The dietary supplements can also include an appropriate neurotransmitter, such as an amino acid. When administered through the oral mucosa, increases in levels of the deficient neurotransmitters and relief from deficiency symptoms are obtained.

专利号:WO-2014059961-A1
优先权日:2012-10-15
标 题 :Method for the synchronous absorption of carbon dioxide from flue gas and synthesis of dialkyl carbonates and alkylene carbonates
发明人：BÃœTTNER HERMANN; Müller Jürgen; JONKER RAPHAEL; DOEDT SEBASTIAN; BOSSE TOBIAS; MAKRAN SEBASTIAN
权利人:BÃœTTNER HERMANN
摘要:The invention relates to a synchronous CCU method (carbon dioxide capture and utilisation) for the absorption of carbon dioxide from flue gas and other CO 2 -containing substance sources and simultaneous synthesis of dialkyl carbonates and alkylene carbonates. The general subject matter of the invention is, in terms of a 'carbon dioxide capture' on the one hand, the absorption of CO 2 from flue gas and other CO 2 -containing substance sources with ammonia and/or amines to form ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates and, in terms of a 'carbon dioxide utilisation' on the other hand, the reaction of ammonium carbamates or ammonium hydrogen carbonates or ureas or urea intermediates with aliphatic, alicyclic or unsaturated alcohols, and including unsaturated aromatic alcohols to give dialkyl carbonates or alkylene carbonates in such a form that the CO 2 n absorption agent is re-released and fed back into the repetitive process again. A repetitive process control is extremely energy and CO 2 n efficient.

专利号:WO-2016088138-A1
优先权日:2014-12-01
标题 :Diphenyloxiranes, process for preparation thereof, and its use in an enantioselective synthesis of (+)-sertraline
发明人：SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM; KAMBLE ROHIT BALKRISHNA
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses substituted diphenyloxiranes and process for synthesis thereof. The present invention also provides a process for production of enantiomerically pure anti-3,3' -diphenylmethyloxirane and anti-3,3'- diphenylpropan- 1,2-diol from racemic anti-3,3' -diphenylmethyloxirane using hydrolytic kinetic resolution. Further it provides a process for preparation of enantioselective (+)- Sertraline from anti-3,3' -diphenylpropan-1,2-diol.

专利号:US-8716507-B2
优先权日:2008-10-31
标题 :Iron(II) catalysts containing diimino-diphosphine tetradentate ligands and their synthesis
发明人：MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA
权利人:MIKHAILINE ALEXANDRE; FREUTEL FRIEDERIKE; SUI-SENG CHRISTINE; MEYER NILS; MORRIS ROBERT H; LAGADITIS PARASKEVI OLYMPIA; GOVERNING COUNCIL OF UNIVERSITY OF TORONTO
摘要:New hexa-coordinate iron (II) complexes comprising compounds of formula (I) are described. These compounds comprise a tetradentate ligand with donor atoms comprising nitrogen and phosphorus. These complexes are shown for the first time to be useful catalysts for the hydrogenation of ketones, aldehydes, or imines to produce alcohols or amines, and the asymmetric hydrogenation of prochiral ketones or imines to produce non-racemic alcohols or amines. The source of the hydrogen can be hydrogen gas or a hydrogen-donating molecule such as isopropanol or hydrogen-donating mixture such as formic acid and an amine depending on the structure of the catalyst. In certain embodiments, the axial ligands on the catalyst comprise organonitrile ligands, carbonyl ligands, isonitrile ligands, or combinations thereof. The catalysts and the preparation thereof are disclosed. A reaction using phosphine and diamine precursors that is templated by the iron ion is the preferred route to the catalysts.

专利号:WO-2020025646-A1
优先权日:2018-07-30
标题:An omega-transaminase enzyme
发明人：MAGUIRE ANITA; GAVIN DECLAN; O'GARA FERGAL; REEN JERRY
权利人:UNIV COLLEGE CORK NATIONAL UNIV OF IRELAND CORK
摘要:An isolated w-transaminase enzyme comprising an amino acid sequence of SEQUENCE ID NO: 1, or encoded by a nucleic acid sequence of SEQUENCE ID NO: 2, is provided which is derived from marine sponge Pseudovibrio sp.. Also provided are functional variants of the w-transaminase enzyme that are isolated, have at least 80% sequence identity with SEQUENCE ID NO: 1, and are capable of enantioselectively resolving a racemic amine by transformation to a ketone by oxidative deamination, or enantioselectively resolving a racemic ketone by transformation to an amine by reductive amination, in which the amine and ketone typically contain a stereocentre removed from the reacting site. An example of a functional variant is SEQUENCE ID NO:3. In one embodiment, the functional variant is capable of enantioselectively transforming a (4S) -tetralone intermediate in the synthesis of sertraline, in which the functional variant displays remote stereospecificity for the tetralone intermediate.