CAS: 79110-05-7; 1-(2-Fluoro-5-Nitrophenyl)Ethanone

上下游产品

CAS号445-27-2 邻氟苯乙酮 | CAS号701-45-1 2-溴-1-氟-4-硝基苯 | CAS号97674-02-7 三丁基(1-乙氧基乙烯)锡 | CAS号709-46-6 2-氟-5-硝基苯甲酰氯 | CAS号75-16-1 甲基溴化镁 | CAS号40621-84-9 3-甲基-5-硝基-1H-吲唑 | CAS号67500-19-0 2-氟-5-氨基苯乙酮

2'-氟苯乙酮置于硫酸,硝酸体系中,化学反应 0.25H,以86%的收率获得产物1-(2-氟-5-硝基苯基)乙-1-酮
参考文献:喹诺酮类抗菌药.1. 7-(2-取代的4-噻唑基和噻唑烷基)喹诺酮
标题:喹诺酮类抗菌药.1. 7-(2-取代的4-噻唑基和噻唑烷基)喹诺酮
摘要:合成了一系列的7-(2-取代的4-噻唑基和噻唑烷基)-1-乙基-1,4-二氢-4-氧代喹啉-3-羧酸及其6-氟类似物.汉茨法用于制备噻唑基喹诺酮.通过将相应的噻唑基类似物季铵化,然后用水溶液中的硼氢化钠还原获得的噻唑鎓盐,来合成噻唑烷二基喹诺酮.在体外测试抗菌活性.大多数化合物对革兰氏阴性菌无活性,但其中一些对革兰氏阳性菌和分枝杆菌显示出非常好的活性.在喹诺酮类抗菌剂中很少发现这种活性模式.
DOI:10.1002/jhet.5570280323

专利信息

专利号:US-10035796-B2
优先权日:2014-08-14
标题:Crystalline forms of a BACE inhibitor, compositions, and their use
发明人：KAZAKEVICH IRINA; TRZASKA SCOTT; FENG TAO
权利人:MERCK SHARP & DOHME
摘要:The present invention provides a novel synthesis of verubecestat, and two novel crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful in treating, preventing, ameliorating, and/or delaying the onset of an Aβ pathology and/or a symptom or symptoms thereof. Non-limiting examples of such Aβ pathologies, including Alzheimer's disease, are disclosed herein.

专利号:US-7648986-B2
优先权日:2002-01-10
标题:Substituted thieno[3,2-D]pyrimidines as Rho kinase inhibitors
发明人：NAGARATHNAM DHANAPALAN; KHIRE UDAY; ASGARI DAVOUD; SHAO JIANXING; LIU XIAO-GAO; WANG CHUNGUANG; HART BARRY; WEBER OLAF; LYNCH MARK; ZHANG LEI; WANG LEI
权利人:BAYER HEALTHCARE LLC
摘要:Disclosed are compounds and derivatives thereof their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.