CAS: 765-46-8; Spiro[2.4]Hepta-4,6-Diene

上下游产品

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二聚环戊二烯置于甲基三丁基氯化铵,Sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 2.0H,反应生成 螺[2.4]庚-4,6-二烯
参考文献:环戊二烯相转移催化双烷基化的连续工艺合成螺[2.4]庚-4,6-二烯
标题:环戊二烯相转移催化双烷基化的连续工艺合成螺[2.4]庚-4,6-二烯
摘要:提出了使用标准的和广泛使用的实验室设备将环戊二烯与1,2-二氯乙烷的高放热相转移催化双烷基化从间歇模式转移到连续模式.除了优化反应温度和停留时间外,还可以有效地混合有机相(环戊二烯,1,2-二氯乙烷和mebu 3Ncl)和水相(30%naoh)进行了详细研究,并通过使用简单的自制" Ptfe Raschig环式静态混合器"进行了优化,该混合器由ptfe管组成,并填充有从同一pfte管切下来的小块.具有两个ptfe Raschig环静态混合器和三个停留时间单元(具有三阶段温度曲线)的流路设置允许以95%的收率合成高能螺旋[2.4]庚-4,6-二烯,产率高在安全条件下为15 G / H.
DOI:10.1021/acs.Oprd.5B00046

专利信息

专利号:US-9193674-B2
优先权日:2011-10-14
标题 :Process for the preparation of aminoacrylic acid derivatives
发明人：REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; PANDRANGI SIVA SWAROOP
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to a simple, economical and short synthesis for the class of compounds chemically belonging to amino acrylic acids of general formula I exhibiting both antibacterial and anti-plasmodium (anti-malarial) activity, in good yield and purity. Process for the preparation of said compound comprising heating amine (A) and pantolactone or substituted pantolactone (B) in a solvent selected from cyclohexane, benzene, toluene, xylene, dipheny!ether; anisole, dioxane, etc. at a temperature in the range of 110-150° C. for about 24 hrs followed by further raising the temperature of the mixture to a temperature in the range of 200-230° C. for period in the range of 15 to 25 min followed by cooling the crude reaction mixture to room temperature to obtain compound of general Formula I.