CAS: 66715-65-9; Pyridine-2-Sulfonyl Chloride

上下游产品

2-Sulfanylpyridine hydrogenchloride chlorine 2-bromo-pyridinepyridine-2-sulfonic acid-[2]pyridylamide pyridine-2-sulfonic acid dimethylamide N-Phenylpyridine-2-sulfonamide 2-pyridinesulfonamide

📜2,2'-二硫二吡啶置于sodium Hydrogen Sulfate,Sodium Hypochlorite Pentahydrate体系中,用87 %的收率获得产物吡啶-2-磺酰氯
参考文献:通过可伸缩,环保且经济高效的工艺机械合成磺酰胺
标题:通过可伸缩,环保且经济高效的工艺机械合成磺酰胺
摘要:在此,我们展示了一种无溶剂机械化学方法,涉及由固体次氯酸钠(naocl.5H2O)介导的一锅双步程序,用于合成磺酰胺.该方案需要在催化固体酸性物质存在下对二硫化物进行串联氧化氯化反应,然后在路易斯酸碱固体无机试剂的促进下进行胺化.该方法适用于芳香族和脂肪族二硫化物和胺.纯化过程充分考虑了环境问题,避免了恶劣的条件,以获得纯净的磺酰胺产品.一些相关的生物活性化合物已经用此过程制备.
DOI:10.1039/d3Gc01894F

专利信息

专利号:US-6943254-B2
优先权日:1997-03-07
标 题 :Synthesis of pyrazinyl pyridine-3-sulfonamide compounds
发明人：HOGAN PHILIP JOHN
权利人:ASTRAZENECA UK LTD
摘要:A process for the manufacture of: n n nwherein R is (1-4C)alkyl, carboxyl(1-4C)alkyl or 1,3,4-oxadiazol-2-yl comprises:n (a) reaction of the diazonium salt of 3-amino-2-chloropyridine with thionyl chloride in water and an electron transfer catalyst; (b) reaction with isobutyl-(3-methoxy-5-methylpyrazin-2-yl)carbamate and an alkali metal hydride in inert solvent; and (I) where R is (1-4C)alkyl, carboxy(1-4C)alkyl: (c) reaction with a boronic acid: n n (or an anhydride or ester therof) in the presence of a base and a palladium or nickel catalyst in solvent; and removal of the isobutoxy carbonyl group; or (ii) where R is 1,3,4-oxadiazol-2-yl (c) reaction with 4-methoxycarbonylphenylboronic acid (or an anhydride or ester thereof) with a source fluoride ion under aqueous conditions; (d) removal of the isobutoxycarbonyl protecting group; (e) conversion of the methyl ester group to the hydrazide; and (f) conversion to a 1,3,4-oxadiazol-2-yl moiety.

专利号:WO-03045909-A2
优先权日:2001-11-21
标 题 :Methods and intermediates for the synthesis of azepines

专利号:EP-0877022-A1
优先权日:1997-05-09
标 题:Synthesis of the sulfonylpyrimidine derivatives with anticancer activity

专利号:US-2008194629-A1
优先权日:2005-05-03
标题 :3-Mono-and 3,5-Disubstituted Piperidine Derivatives as Renin Inhibitors
发明人：BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
权利人:BAESCHLIN DANIEL KASPAR; BREITENSTEIN WERNER; EHRHARDT CLAUS; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; ZIMMERMANN JUERG; RUDISSER SIMON; VANGREVELINGHE ERIC; IRIE OSAMU; UMEMURA ICHIRO; SUZUKI MASAKI; MOGI MUNETO; KANAZAWA TAKANORI; YOKOKAWA FUMIAKI; NIHONYANAGI ATSUKO
摘要:The invention relates to 3,5-piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-piperidine compound, and/or a method of treatment comprising administering a 3,5-piperidine compound, a method for the manufacture of a 3,5-piperidine compound, and novel intermediates and partial steps for their synthesis. Especially, the 3,5-piperidine compounds have the formula I, wherein the symbols have the meanings described in the specification.

专利号:US-4722749-A
优先权日:1986-06-27
标题 :Pyridinesulfonamides and their use as herbicidal agents
发明人：LEE SHY-FUH
权利人:SANDOZ LTD
摘要:Substituted 2-pyridinesulfonamide 1-oxides, synthesis thereof, intermediates therefor, and the use of said compounds for the control of weeds.

专利号:CN-106432067-A
优先权日:2016-09-18
标题 :A kind of green chemical synthesis method of 3-pyridinesulfonyl chloride