CAS: 6169-06-8; (S)-Octan-2-Ol

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5978-70-1 123-96-6 111-13-7

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CAS号4128-31-8 仲辛醇 | CAS号5978-70-1 L-2-辛醇 | CAS号124-07-2 辛酸 | CAS号34760-88-8 rac-2-°Ctyl sulfate | CAS号142-62-1 正己酸 | CAS号111-13-7 2-辛酮 | CAS号111-71-7 正庚醛 | CAS号75-24-1 三甲基铝 | CAS号544-97-8 二甲基锌 | CAS号66-25-1 正己醛 | CAS号10340-41-7 di°Ctan-2-yl de... | CAS号108-63-4 己二酸二(1-甲基庚基)酯 | CAS号557-35-7 2-溴辛烷 | CAS号4286-15-1 (S)-(+)-2-苯基丁酸 | CAS号938-79-4 (R)-(-)-2-苯基丁酸 | CAS号126415-96-1 (2R)-°Ctan-2-yl... | CAS号111-66-0 1-辛烯 | CAS号18651-57-5 (2R)-2-chloro°Ctane | CAS号5978-70-1 L-2-辛醇

仲辛酮置于2,3,4,5,6-Pentahydroxy-Hexanal,Bacillus Megaterium Glucose Dehydrogenase,Recombinant Hansenula Polymorpha Ketoreductase,Nicotinamide Adenine Dinucleotide体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应 24.0H,以99%的收率获得产物
参考文献:多形汉逊酵母强大的酮还原酶在还原羰基化合物中的应用
标题:多形汉逊酵母强大的酮还原酶在还原羰基化合物中的应用
摘要:酶催化的酮的不对称还原是生产手性构件或合成生物活性化合物的前体的有吸引力的工具.扩大了多形汉逊酵母中健壮的酮还原酶(kred)的表达,并将其用于将31种手性羰基化合物(脂族和芳族酮,二酮和β-酮酯)不对称还原为相应的光学纯羟基化合物.用纯化的重组kred和nadp +循环葡萄糖脱氢酶(gdh,Bacillus Megaterium)进行生物转化,二者均在大肠杆菌中过表达.bl21(de3).用于由高细胞密度培养实现乙基-2-甲基乙酰的生物转化kred的最大活性为2499.7+/-234ü克-1 Dcw和8.47+/-0.40 U.毫克-1 ê,分别.多形汉逊酵母的kred是一种用途非常广泛的酶,具有广泛的底物特异性,并且对具有各种结构特征的羰基底物具有很高的活性.在这项研究中筛选的36种羰基底物中,Kred在31种情况下显示出活性,在大多数情况下具有高对映选择性.多态汉逊酵母kred具有几种酮
DOI:10.1016/j.Mcat.2020.111364

专利信息

专利号:US-10023677-B2
优先权日:2014-12-16
标 题 :Method for controlling the synthesis of a block copolymer containing at least one nonpolar block and at least one polar block and use of said block copolymer in applications of nanolithography by direct self-assembly
发明人：NAVARRO CHRISTOPHE; NICOLET CELIA; CHEVALIER XAVIER
权利人:ARKEMA FRANCE
摘要:A method for controlling the synthesis of a block copolymer containing at least two blocks, with at least one nonpolar block and at least one polar block, said method making it possible in particular to control the ratio between the blocks and the molecular weight of each of the blocks, said copolymer being a block copolymer intended to be used as a mask in a method of nanolithography by direct self-assembly (DSA), said control being achieved by semicontinuous anionic polymerization in an aprotic nonpolar medium.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-5585252-A
优先权日:1988-08-30
标 题 :Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
发明人：WONG CHI-HUEY; WANG YI-FONG; HENNEN WILIAM J
权利人:SEARLE & CO
摘要:A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizes to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.

专利号:US-5106750-A
优先权日:1988-08-30
标 题:Enantio- and regioselective synthesis of organic compounds using enol esters as irreversible transacylation reagents
发明人：WONG CHI-HUEY; WANG YI-FONG; HENNEN WILLIAM J; BABIAK KEVIN A; DYGOS JOHN H; NG JOHN S
权利人:SEARLE & CO
摘要:A process for irreversible regio- and stereoselective enzyme catalyzed acylation of alcohols using enol esters as acylating reagents is disclosed. The present invention permits the selective modification of hydroxyl group(s) of chiral and meso alcohols, including sugars, organometallics, and glycosides. The enol freed upon transesterification rapidly tautomerizes to the corresponding volatile aldehyde or ketone thereby preventing the reverse reaction from occurring.

专利号:US-5420037-A
优先权日:1989-09-26
标 题:Process for separation of enantiomeric 3-mercapto-2-substituted alkanoic acid using lipase P30 and synthesis of captopril type compounds
发明人：HOWELL JEFFREY M; PATEL RAMESH N; SZARKA LASZLO J
权利人:SQUIBB & SONS INC
摘要:S-enantiomers of the formula I result from the reaction of a racemic form of compound I with an alcohol in the presence of an enzyme capable of selectively esterifying the R-enantiomers of the racemic compound.

专利号:US-6255092-B1
优先权日:1993-09-24
标题:Stereospecific alcohol dehydrogenase isolated from Candida parapsilosis, amino acid and DNA sequences therefor, and method of preparation thereof
发明人：KOJIMA TOMOKO; YAMAMOTO HIROAKI; KAWADA NAOKI; MATSUYAMA AKINOBU
权利人:DAICEL CHEM
摘要:The present invention provides a novel secondary alcohol dehydrogenase useful for the synthesis of optically active alcohol and DNA encoding said enzyme. A microorganism belonging to genus Candida was found to produce a novel secondary alcohol dehydrogenase with a high stereochemical specificity. Using said enzyme, optically active alcohols were prepared, and by cloning of DNA encoding said enzyme, the base sequence of said DNA was determined. By providing a novel secondary alcohol dehydrogenase with a high stereochemical specificity and the gene encoding said enzyme, an efficient production of optically active alcohols became possible.