CAS: 6136-68-1; 3-Acetylbenzonitrile

该化合物是一个有机化合物, 其特征为乙酰组和附于苯环的硝酸盐组, 这种化合物一般看起来无色可粉黄色液体或固体, 取决于其纯度和温度, 其分子式为C10H7NO, 表明存在十个碳原子, 七个氢原子, 一氮原子 和 一氧原子, 其特点是其芳香结构, 有助于其稳定性和回活动. 3-Acetylbenzonitrile因其在有机合成中的应用, 特别是在生产药品和农用化学品时的应用而闻名. 它可以经受各种化学反应, 包括核分裂替代和电动动力替代, 使其在合成化学化学中成为多用途的中间体. 此外, 它可能在有机溶剂中表现出中等溶性, 其物理特性可以因环境条件而有所不同. 安全数据在处理和储存时, 需要参考任何化学物质.

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CAS号557-21-1 氰化锌 | CAS号2142-63-4 3-溴代苯乙酮 | CAS号41908-11-6 3-乙酰苯甲醛 | CAS号14452-30-3 3'-碘苯乙酮 | CAS号6952-59-6 间溴苯甲腈 | CAS号75-36-5 乙酰氯 | CAS号773837-37-9 sodium cyanide | CAS号6213-94-1 乙烯氧基三甲基硅烷 | CAS号69113-59-3 3-碘苯甲腈 | CAS号108-24-7 乙酸酐 | CAS号105802-54-8 3-(2-氧代乙酰基)-苯甲腈 | CAS号50916-55-7 3-氰基苯酰甲基溴 | CAS号145276-31-9 3-[3-(二甲基氨基)-1-... | CAS号93717-55-6 2-氰基-4’-甲基联苯 | CAS号202664-32-2 3-(2-AMINO-THIA... | CAS号76-05-1 三氟乙酸(TFA) | CAS号29265-83-6 3-(1-phenylethe... | CAS号207909-05-5 3-(1-甲基-1H-吡唑-3... | CAS号21860-07-1 3-乙酰基苯甲酸甲酯

合成工艺路线路线简述

    间溴苯甲腈置于palladium Diacetate,1,3-双(二苯基膦)丙烷 盐酸体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 12.5H,反应生成 3-乙酰苯腈
    参考文献:.Alpha.-Regioselectivity In Palladium-Catalyzed Arylation Of Acyclic Enol Ethers
    标题:.Alpha.-Regioselectivity In Palladium-Catalyzed Arylation Of Acyclic Enol Ethers
    摘要:Regioselective Alpha-Arylation Of Acyclic Enol Ethers By Aryl Trifluoromethanesulfonates,Aryl Bromide,Aryl Iodides,And Aroyl Chlorides Is Described. The Outcome Of The Reaction Proved To Be Dependent From The Relationship Between Ligand And Counterion In The Oxidative Addition Complex.
    DOI:10.1021/jo00031A029

    海关参考信息

    专利信息


    专利号:US-7951827-B2
    优先权日:2005-05-05
    标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
    发明人:TIDWELL RICHARD R; BAKUNOVA SVETLANA M; BAKUNOV STANISLAV; PATRICK DONALD A
    权利人:UNIV NORTH CAROLINA
    摘要:Novel dicationic 3,5-diphenylisoxazole compounds are described. Synthetic routes to these novel compounds are provided. Several of the compounds displayed in vitro activity versus Trypanosoma brucei brucei and Plasmodium falciparum comparable to that of furamidine. A majority of the novel compounds also were less toxic to VERO cells than furamidine.

    专利号:AU-3213599-A
    优先权日:1998-04-03
    标 题:A convergent synthesis of alpha-aryl-beta-ketonitriles

    专利号:US-2006264487-A1
    优先权日:2005-05-05
    标 题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

    专利号:US-8513241-B2
    优先权日:2008-03-28
    标题 :3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    发明人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA
    权利人:CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; SALOM BARBARA; NERVIANO MEDICAL SCIENCES SRL
    摘要:Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

    专利号:AU-2006201739-A1
    优先权日:2005-05-05
    标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles

    专利号:EP-1719767-A1
    优先权日:2005-05-05
    标题:Synthesis and antiprotozoal activity of dicationic 3,5-diphenylisoxazoles
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    主要参考文献

    [参考文献]: C Y Watson, Et Al. Synthesis Of 3-Substituted Benzamides And 5-Substituted Isoquinolin-1(2H)-Ones And Preliminary Evaluation As Inhibitors Of Poly(Adp-Ribose)Polymerase (Parp). Bioorg Med Chem. 1998 Jun;6(6):721-34.

    合成参考文献


    摘要:Margaretha, P., Science of Synthesis Knowledge Updates, (2010) 4, 412.
    摘要:Gosmini, C.; Corpet, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 710.
    摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 132.
    摘要:Liu, S.; Xiao, J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 226.
    摘要:Liu, S.; Xiao, J., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 3, 217.
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