合成目标产物 Sulfamic Acid 主要起始原料 Sulfur Trioxide And P-Toluidine
(文献来源)合成步骤主要原料 Sulfur Trioxide 和 P-Toluidine
磺酰胺置于水体系中,化学反应生成 氨基磺酸 参考文献:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: S: Mvol.B3,25,Page 1582-1584 标题:Gmelin Handbuch Der Anorganischen Chemie,Gmelin Handbook: S: Mvol.B3,25,Page 1582-1584
专利信息
专利号:US-10751419-B2 优先权日:2014-05-01 标题:Method for synthesis of reactive conjugate clusters 发明人:MIGAWA MICHAEL T; YU JINGHUA; WAN W BRAD; PATEL SAYTEN P; VASQUEZ GUILLERMO; KINBERGER GARTH A; PRAKASH THAZHA P; SETH PUNIT P; SWAYZE ERIC E 权利人:IONIS PHARMACEUTICALS INC 摘要:Provided herein are improved methods for the synthesis of reactive conjugate clusters and intermediates used in such methods. In particular, improvements are provided that enhance the synthesis of reactive conjugate clusters by reducing the number of synthetic steps required. The reactive conjugate clusters prepared using the improved methods don't include any transacylation impurities that are formed using existing methods. The improved methods also provide an increase in overall yield and a cost benefit over existing methods.
专利号:US-2021053913-A1 优先权日:2019-08-22 标题 :Process for the Synthesis of Fluorinated Conductive Salts for Lithium Ion Batteries 发明人:ZHOU CHANGYUE; DU HONGJUN; WU WENTING 权利人:FUJIAN YONGJING TECH CO LTD 摘要:The invention relates to a new process for the synthesis of fluorinated conductive salts for lithium ion batteries (Li-ion batteries). The said fluorinated conductive lithium ion (Li-ion) battery salts of interest in the framework of the present inventions synthesis process, for example, are Li-ion salts such as LiFSI (lithium bis-(fluoromethanesulfonlyl) imide), LiTFSI (lithium bis-(trifluormethanesulfonlyl) imide), and LiTFSFI (lithium trifluoromethanesulfonylfluorosulfonyl imide), with the formulas as displayed in the Table I herein below. LiFSI, LiTFSI and LiFSTFSI are the most promising conducting salts for Lithium ion batteries and essential for future electromobility.
专利号:US-3875167-A 优先权日:1972-05-26 标 题 :Synthesis of thalicarpine 发明人:KUPCHAN S MORRIS; LIEPA ANDRIS J 权利人:RESEARCH CORP 摘要:There is disclosed a novel total synthesis of thalicarpine which includes inter alia a total synthesis of hernandaline. The novel process is characterised in utilizing simple and readily available starting materials to form a diaryl ether system which is then condensed with a 3,4-dihydroisoquinolinium salt which is then converted to hernandaline. Hernandaline is reacted with a bicyclic Reissert compound to yield a compound having the thalicarpine skeleton, nascent hydrogen reduction yields Nmonodesmethyl thalicarpine which is methylated.
专利号:WO-03066549-A3 优先权日:2002-02-07 标题:Synthesis of sulfamidates 发明人:NICOLAOU KYRIACOS C; SNYDER SCOTT A; HUANG XIANHAI 权利人:SCRIPPS RESEARCH INST; NICOLAOU KYRIACOS C; SNYDER SCOTT A; HUANG XIANHAI 摘要:A regio- and stereoselective two-stage synthesis of β-aminoalcohols employs a key transformation, viz., the creation of a cyclic sulfamidate from a precursor diol, mediated by Burgess-type reagents. The generality and scope of this approach is underscored by the considerable number and variety of substrates which display high levels of selectivity in the process. As such, this method provides facile access to compounds for use in myriad applications, whether as chiral ligands to perform asymmetric synthesis or as molecular probes to explore problems in chemical biology.
专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:US-2008146656-A1 优先权日:2005-06-01 标题:Use of a steroid sulphatase inhibitor for inhibiting the synthesis of androstenedione and/or testosterone 发明人:REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD 权利人:REED MICHAEL JOHN; PUROHIT ATUL; WOO LOK WAI LAWRENCE; POTTER BARRY VICTOR LLOYD 摘要:There is provided use of a compound capable of inhibiting a steroid sulphatase enzyme (E.C.3.1.6.2) in the manufacture of a medicament for inhibiting in vivo synthesis of at least one of androstenedione and testosterone, which may be useful for the treatment of hirsutism, excess sebum production, benign breast disease, benign ovarian disease, polycystic ovarian disease and female infertility among others.
1: Pszona M, Haupa K, Bil A, Mierzwicki K, Szewczuk Z, Mielke Z. Clustering of sulfamic acid: ESI MS and theoretical study. J Mass Spectrom. 2015 Jan;50(1):127-35. doi: 10.1002/jms.3505. doi: 10.1016/j.bmcl.2015.03.054. Epub 2015 Mar 26. doi: 10.1021/cr400230c. Epub 2013 Dec 17. doi: 10.1021/jacs.6b02130. Epub 2016 Apr 15. doi: 10.1016/j.carres.2016.09.002. Epub 2016 Sep 7. doi: 10.1063/1.4807864. doi: 10.1039/c6cc02350a. doi: 10.1016/j.biortech.2011.08.001. Epub 2011 Aug 9. doi: 10.1002/rcm.4307. doi: 10.1007/s11030-008-9089-5. Epub 2008 Oct 1. Epub 2006 Jan 4. doi: 10.1016/j.talanta.2013.03.032. Epub 2013 Mar 22. doi: 10.1016/j.ultsonch.2009.03.008. Epub 2009 Mar 27. doi: 10.1007/s11030-009-9196-y. Epub 2009 Sep 30. German. Epub 2006 Dec 4.
合成参考文献
参考文献:10.1016/j.bmc.2011.06.038 摘要:Nishimori I, Minakuchi T, Vullo D, Scozzafava A, Supuran CT. Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates. Bioorg Med Chem. 2011 Aug 15;19(16):5023–30. doi: 10.1016/j.bmc.2011.06.038.