CAS: 52704-70-8; 2,2',3,3',5,6-Hexachlorobiphenyl

该化合物是一种氯化联苯化合物,具有定义的六氯代用品模式,该化学品具有持久性和潜力,可作为多氯联苯(PCB)分析的参考标准,因此对环境和分析化学具有兴趣,其性质清晰的结构有助于在复杂的矩阵中准确识别和量化,从而对多氯联苯降解,毒理学和环境监测的研究具有价值.该化合物的稳定性和高纯度使其适合用于校准标准和方法验证研究.

英文名称2,2',3,3',5,6-Hexachlorobiphenyl
中文名称2,2’,3,3’,5,6-六氯联苯
IUPAC名称1,2,4,5-tetrachloro-3-(2,3-dichlorophenyl)benzene
其它别名2,2',3,3',5,6-Hexachlorobiphenyl; 2,2',3,3',5',6'-Hexachlorobiphenyl; 2,3,2',3',5',6'-Hexachlorobiphenyl; 2,3,5,6,2',3'-Hexachlorobiphenyl
CAS编号52704-70-8
MFCD编号:MFCD00674466
FDA UNII编号:V584EA6T0Z
分子式:C12H4Cl6分子量:360.88
产品CID: 2496374
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
产品信息参考;;;;
InChIKey: RVWLHPJFOKUPNM-UHFFFAOYSA-N
1S/C12H4Cl6/c13-6-3-1-2-5(10(6)16)9-11(17)7(14)4-8(15)12(9)18/h1-4H
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,2,4,5-Tetrachloro-3-iodobenzene 1,2-Dichloro-3-iodobenzene

合成工艺路线路线简述

📜1,2,4,5-四氯-3-碘苯,2,3-二氯碘苯置于铜体系中,用 N,N-二甲基甲酰胺作为反应溶剂,化学反应生成 2,2',3,3',5,6-六氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4