CAS: 446-36-6; 5-Fluoro-2-Nitrophenol

上下游产品

CAS号446-35-5 2,4-二氟硝基苯 | CAS号7631-86-9 单分散二氧化硅微球 | CAS号372-20-3 3-氟苯酚 | CAS号7664-93-9 硫酸 | CAS号64-19-7 冰醋酸 | CAS号312600-96-7 6-氟-2-甲基苯并噁唑 | CAS号367-32-8 4-氟-1,2-苯二酚 | CAS号448-19-1 5-氟-2-硝基苯甲醚 | CAS号145096-57-7 2-疏基-6-氟苯并噁唑 | CAS号450-91-9 4-氟-2-甲氧基苯胺 | CAS号28987-46-4 4-氟-2-异丙氧基硝基苯 | CAS号28987-47-5 2-丁氧基-4-氟-1-硝基苯 | CAS号2924-30-3 2,4-二溴-3-氟-6-硝基苯酚 | CAS号704-14-3 5-甲氧基-2-硝基苯酚 | CAS号53981-24-1 2-氨基-5-氟苯酚

3-氟苯酚置于nitronium Tetrafluoborate体系中,用 乙腈 作为反应溶剂,化学反应 1.0H,反应生成 5-氟-2-硝基苯酚
参考文献:Non-Steroidal Dissociated Glucocorticoid Agonists: Indoles As A-Ring Mimetics And Function-Regulating Pharmacophores
标题:Non-Steroidal Dissociated Glucocorticoid Agonists: Indoles As A-Ring Mimetics And Function-Regulating Pharmacophores
摘要:We Report A Sar Of Non-Steroidal Glucocorticoid Mimetics That Utilize Indoles As A-Ring Mimetics. Detailed Sar Is Discussed With A Focus On Improving Pr And Mr Selectivity,Gr Agonism,And In Vitro Dissociation Profile. Sar Analysis Led To Compound (R)-33 Which Showed High Pr And Mr Selectivity,Potent Agonist Activity,And Reduced Transactivation Activity In The Mmtv And Aromatase Assays. The Compound Is Equipotent To Prednisolone In The Lps-Tnf Model Of Inflammation. In Mouse Cia,At 30 Mg/kg Compound (R)-33 Inhibited Disease Progression With An Efficacy Similar To The 3 Mg/kg Dose Of Prednisolone. (C) 2011 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2011.09.018

专利信息

专利号:US-2016194279-A1
优先权日:2012-12-09
标 题 :One pot process for the conversion of aroyl chlorides to acyl thioureas
发明人：CHEPURI VENKATA RAMANA; BEERAN SENTHILKUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R′ is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R″ and R′″ are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.

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