CAS: 3279-26-3; Dichloro(Methoxy)Phosphane

上下游产品

methanol phosphorous acid trimethyl ester dimethyl chlorophosphite tin(IV) chloridetrichloromethylphosphonous dichloride tert-butyl-phenyl ester)-methyl esterphosphorous acid bis-(4-tert-butyl-phenyl ester)-methyl ester α-hydroxybenzylphosphonate de methyle methoxy-2 dioxaphospholane-1,3,2

📜甲氧基三甲基硅烷置于吡啶,三氯化磷体系中,用 二氯甲烷 作为反应溶剂,化学反应 27.0H,以70%的收率获得产物二氯亚磷酸甲酯
参考文献:亚磷酸二氯,亚氯酸和亚磷酸三烷基酯的合成新方法
标题:亚磷酸二氯,亚氯酸和亚磷酸三烷基酯的合成新方法
摘要:使用相应的氯膦和烷氧基三甲基硅烷的 Hcl 催化反应,通过烷氧基和氯配体 (P Iii Cl/rosir' 3) 的相互交换,可以很容易地合成不同的三价有机磷酯,例如二氯亚磷酸酯,亚磷酸酯和混合亚磷酸三烷基酯. ;交换反应).还研究了分别与伯烷氧基三甲基硅烷和仲烷氧基三甲基硅烷以及烷氧基三甲基硅烷和硫代烷氧基三甲基硅烷的交换反应的化学选择性.还发现氯膦与仲胺的取代反应比与rosir' 3 的交换反应发生得更快.
DOI:10.1080/10426500902719222

专利信息

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-6340749-B1
优先权日:1995-10-06
标题:Preparation of nucleoside phosphoramidites and oligonucleotide synthesis
发明人：ZHANG ZHAODA; TANG JIN-YAN
权利人:AVECIA BIOTECHNOLOGY INC
摘要:The invention provides novel bifunctional phosphitylating reagents and their application in in situ preparation of 5'-protected nucleoside phosphoramidites and synthesis of oligonucleotides. Bifunctional phosphitylating reagents according to the invention react quickly with nucleosides under neutral or weakly basic conditions, without an additional activation step. In addition, the bifunctional phosphitylating reagents according to the invention generate chemoselectively the corresponding nucleoside phosphoramidites in situ, without need to purify the nucleoside phosphoramidites before using them in oligonucleotide synthesis. Finally, the bifunctional phosphitylating reagents according to the invention are relatively stable and easy to handle.

专利号:US-5021550-A
优先权日:1986-10-07
标 题 :Method for preventing deletion sequences in solid phase synthesis
发明人：ZEIGER ALLEN R
权利人:UNIV JEFFERSON
摘要:Improved methods for solid-state synthesis of polymers, especially polypeptides and polynucleotides, are provided. In accordance with a preferred embodiment, selectively activatable and reactive bonding moieties are covalently bonded to solid supports for polynucleotide and polypeptide syntheses. Products of failed reactions and some side products are caused to react with the selectively activatable and reactive bonding moiety to cause divalent bonding of unwanted products to the solid support. Upon cleavage of the initial situs of covalent bonding to the solid support, desired products are free to be collected while unwanted products remain covalently bonded to the support. Ease of purification of such polymers is a principal object of the present invention. The methods of the invention are amenable to automation and digital control and novel solid supports, activatable, reactive bonding moieties and other compositions are presented. The expression of polynucleotides prepared in accordance with preferred embodiments produces novel polypeptides.

专利号:US-7687652-B2
优先权日:2004-01-15
标题:Sphingomyelin, intermediates thereof and methods for preparation of same
发明人：ROCHLIN ELIMELECH; HILDESHEIM JEAN; BERLIN ALISA
权利人:BIOLAB LTD
摘要:Novel cyclic and acyclic oxazaphospholanes are described, as well as their use in the synthesis of sphingomyelin and sphingomyelin analogous. The production of synthetic sphingomyelins is also described. 2S, 3R stereoisomers of oxazaphospholanes and sphingomyelins, and synthetic methods for their preparation are described.

专利号:EP-0115613-B1
优先权日:1982-12-24
标题:Dna sequences, their preparation, plasmids containing these sequences and their use in the synthesis of eukaryotic gene products in prokaryotes
摘要:The present invention relates to the combination of the promoter/operator region of the tryptophan operon of Serratia marcescens with a synthetic ribosome binding sequence, an expression plasmid which contains this sequence and in which the above sequence is followed by the only Hind III cleavage site in the plasmid, into which site the gene to be expressed can be inserted, and to production plasmids for the expression of eukaryotic gene products in prokaryotes, especially for the preparation of leucocyte interferon.

专利号:US-4500707-A
优先权日:1980-02-29
标题:Nucleosides useful in the preparation of polynucleotides
发明人：CARUTHERS MARVIN H; MATTEUCCI MARK D
权利人:UNIVERSITY PATENTS INC
摘要:New and useful intermediate nucleotides bound to an inorganic polymer support, including the preparation thereof, and processes for the conversion to oligonucleotides which are especially useful for the synthesis of polynucleotides, particularly ribonucleic (RNA) and deoxyribonucleic acids (DNA).