CAS: 3055-99-0; 3,6,9,12,15,18,21,24,27-Nonaoxanonatriacontan-1-Ol

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CAS号112-27-6 三甘醇

三乙二醇置于氯化亚砜,Sodium Hydride,三乙胺体系中,用 四氢呋喃,二氯甲烷 作为反应溶剂,化学反应 8.5H,反应生成 聚醚醇
参考文献:单分散九聚乙二醇十二烷基醇单醚及其硫酸盐的制备方法和应用
标题:单分散九聚乙二醇十二烷基醇单醚及其硫酸盐的制备方法和应用
摘要:本发明公开了一种单分散九聚乙二醇十二烷基醇单醚及其硫酸盐的制备方法和应用,属于医药化工领域.从十二烷基醇出发,首先在碱的作用下通过与九聚乙二醇环硫酸酯的一次开环反应或通过与共含有九个乙二醇单元的多个寡聚乙二醇环硫酸酯的多次开环反应得到九聚乙二醇十二烷基醇单醚的硫酸盐;然后在硫酸的作用下水解得到九聚乙二醇十二烷基醇单醚.该方法可用于单分散聚乙二醇的长链烷基单醚及其硫酸盐的制备中.本发明以单一分子量聚乙二醇环硫酸酯为原料实现了六聚以上乙二醇的烷基醇单醚的高效合成,合成中没有用保护基,步骤简便,适于工业化生产,得到的产品相对于现有制备的聚桂醇具有明显的优势.

专利信息

专利号:US-2012190064-A1
优先权日:2004-10-01
标题 :Feeding buffers, systems, and methods for in vitro synthesis of biomolecules
发明人：KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA
权利人:KUDLICKI WIESLAW ANTONI; KEPPETIPOLA SHIRANTHI; FLETCHER JULIA; GETBEHEAD ASHLEY ELAINE; KATZEN FEDERICO; VOZZA-BROWN LAURA; LIFE TECHNOLOGIES CORP
摘要:Compositions, methods and kits for in vitro systems for synthesis of biomolecules such as polypeptides, are provided herein. Cell extracts that provide enhanced yields of soluble proteins using in vitro protein synthesis methods are provided. The invention also includes methods for producing high yields of proteins by the addition of a feeding solution that includes amino acids and an energy source to an ongoing in vitro synthesis system. The invention also includes methods of using a high-yield in vitro synthesis system to produce large quantities of proteins with incorporated labeled amino acids for analysis by methods such as by NMR. The invention further includes vectors for enhanced production of proteins from nucleic acid templates using in vitro synthesis systems.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:WO-2024130393-A1
优先权日:2022-12-21
标 题 :Nanoparticle and method of synthesis thereof
发明人：MOSKOVCHENKO SVITLANA
权利人:MOSKOVCHENKO SVITLANA
摘要:The present technology relates to nanoparticles, compositions comprising said nanoparticles, and methods of synthesis of said nanoparticles; wherein the nanoparticles comprise a metal nanoparticle core, a first coating of amphiphilic molecules, and a second coating of essential oil, essential oil primary constituent, or both, which combine the antimicrobial properties of metal nanoparticles, amphiphilic molecules, and essential oil or essential oil primary constituents.

专利号:US-7282337-B1
优先权日:2006-04-14
标题:Methods for increasing accuracy of nucleic acid sequencing
发明人：HARRIS TIMOTHY D
权利人:HELICOS BIOSCIENCES CORP
摘要:The invention provides methods for improving the accuracy of a sequencing-by-synthesis reaction by sequencing at least a portion of a template and at least a portion of template complementary sequence.

专利号:US-2021008106-A1
优先权日:2019-06-18
标题 :Mitochondrial treatment of organs for transplantation
发明人：PETERSEN THOMAS; HOGAN SARAH; ILAGAN ROGER; CLOER CARYN
权利人:UNITED THERAPEUTICS CORP
摘要:Methods and compositions relating to isolated mitochondria are disclosed. For example, cells, tissues, or organs can be treated with isolated mitochondria, such as porcine mitochondria, to improve mitochondrial function in the cell, tissue, or organ. The improvements to mitochondrial function include increased oxygen consumption and increased ATP synthesis. Such methods and compositions are useful for cell therapy; organ and tissue transplantation; organ and tissue engineering; and cold storage or shipment of harvested organs, tissues, and cells.