CAS: 2973-59-3; 2-Bromo-5-Hydroxy-4-Methoxybenzaldehyde

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异香兰素置于n-溴代丁二酰亚胺(Nbs),溶剂黄146体系中,化学反应生成2-溴-5-羟基-4-甲氧基苯甲醛
参考文献:Cui介导的邻位羰基烯丙基苯的一锅环缩醛化/酮化反应:苯并双环[3.2.1]辛烷核的合成
标题:Cui介导的邻位羰基烯丙基苯的一锅环缩醛化/酮化反应:苯并双环[3.2.1]辛烷核的合成
摘要:已经实现了cui / Dmso介导的邻羰基烯丙基苯的分子内环缩醛化/缩酮化,以高产率构建具有缩酮基序的[6,6,5]-三环.快速的一步式路线可形成三个c-O键.通过x射线晶体学分析证实了具有苯并稠合的二氧杂双环[3.2.1]辛烷核结构框架的关键产品.研发了二氢异香豆素的合成.
Doi:10.1021/acs.Orglett.7B00630

专利信息

专利号:US-4514569-A
优先权日:1982-01-28
标 题 :Synthesis of 1-substituted isoquinolines
发明人：HENDRICKSON JAMES B; RODRIGUEZ CESAR
权利人:HENDRICKSON JAMES B; RODRIGUEZ CESAR
摘要:A method for the synthesis of particular isoquinoline compounds which are useful intermediates in the preparation of members of the family of opium alkaloids, such as morphine and codeine. Steps in the process include the acylation of the isoquinoline nitrogen; reaction of the acylated isoquinoline with a phosphorous compound; and condensation with a benzaldehyde derivative to yield a 1-benzyl isoquinoline.

专利号:US-7985879-B2
优先权日:2007-04-12
标 题 :Process for making galantamine
发明人：WANG LUNGHU; CHEN YUNG FA; HENSCHKE JULIAN PAUL
权利人:SCINOPHARM TAIWAN LTD
摘要:A novel process for the preparation of N-methyl-N-(2-[4-hydroxyphenyl]ethyl)-5-hydroxy-4-methoxy benzene carboxamide, which is useful as an intermediate in the synthesis of (−)-galantamine, comprises the reaction of a 5-hydroxy-4-methoxy benzoic acid derivative with N-methyl-N-(2-[4-hydroxyphenyl]ethyl) amine.

专利号:US-2024116909-A1
优先权日:2021-01-12
标题 :Novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; YAN FASHUN; WANG YANPING; LONG WEI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.

专利号:US-2025108123-A1
优先权日:2021-12-17
标 题:Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; WANG HONGLING; FANG XIONG; CUI YANKAI; YAN FASHUN; SONG BINHUA
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided herein are compound-linker constructs and antibody-drug-conjugates of compounds of formula (Y-1), (Y-2), (Y-3), (A), (B), (C), I, II, III, IV or V that are useful as modulators of STING (Stimulator of Interferon Genes). Also provided are synthesis, compositions and uses of such compound-linker constructs and antibody-drug-conjugates.