CAS: 27527-05-5; (S)-2-Amino-3-Cyclohexylpropanoic Acid

该化合物是一种氨酸衍生物,其特征是存在一种环己基物质组,附于亚麻宁结构的阿尔法碳;该化合物被归类为非极,缺水的氨酸,其原因是多环己基子侧链,影响其溶解性和生物系统中的相互作用;L-Cyclohexylaline因其在丙二酸合成中的潜在应用以及作为制药,特别是基于浸泡物的药物设计中的一个构件而闻名;该化合物的独特结构可影响的相容性和稳定性,使其对药用化学感兴趣;该化合物通常通过各种有机化学方法合成,其特性,例如熔点和溶解性,可因合成和净化的具体条件而不同;与许多氨酸一样,L-Cyclohexylalayine可以参与各种生物化学反应,有助于蛋白结构和功能的复杂性.

结构式图片

相似化合物

307310-72-1 4441-50-3 127095-92-5

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CAS号63-91-2 L-苯丙氨酸 | CAS号25341-42-8 Cbz-L-环己基丙氨酸 | CAS号626-62-0 碘环己烷 | CAS号24371-94-6 chloro(cyclohex... | CAS号60-18-4 L-酪氨酸 | CAS号37736-82-6 B°C-L-环己基丙氨酸 | CAS号25341-42-8 Cbz-L-环己基丙氨酸 | CAS号131288-67-0 (S)-2-氨基-3-环己基-1-丙醇 | CAS号103322-56-1 (S)-(-)-2-(B°C-... | CAS号17193-39-4 (S)-(-)-环己基丙氨酸甲酯盐酸盐 | CAS号40056-18-6 (S)-METHYL 2-AM...

合成工艺路线路线简述

  • 合成目标产物 L-Cyclohexylalanine 主要起始原料 L-Phenylalanine
  • (文献来源)合成步骤主要原料 L-Phenylalanine
L-苯丙氨酸置于磷酸,5% Rhodium-On-Charcoal,氢气体系中,用 水 用作溶剂,60.0 °C,446.08 Kpa 条件下,反应 24.0H,以97%的收率获得l-环己基丙氨酸
参考文献:芳香族氨基酸及其衍生物的还原
标题:芳香族氨基酸及其衍生物的还原
摘要:苯丙氨酸和苯甘氨酸衍生物的催化还原可以用碳或氧化铝上的铑来实现,从而得到相应的环己基衍生物的非常好收率.该过程可以缩放.
Doi:10.1021/op0200773

海关参考信息

专利信息


专利号:WO-2023233371-A1
优先权日:2022-06-03
标 题:A continuous flow process for synthesis of organic azides
发明人:GNANAPRAKASAM BOOPATHY; PANDEY AKANKSHA M; MONDAL SHANKHAJIT
权利人:INDIAN INSTITUTE OF SCIENCE EDUCATION AND RES PUNE IISER PUNE
摘要:The present disclosure relates generally to the field of synthetic organic chemistry. More specifically, the disclosure is directed to a continuous flow process for synthesis of azides from alcohols and peroxides, wherein the process comprises azidation with trimethylsilyl azide and a catalyst Amberlyst-15. It is a non-hazardous, mild and controlled reaction giving good yields of azides. The azides can be further employed for synthesis of medicinally and industrially useful chemicals.

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人:KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人:AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2024391773-A1
优先权日:2023-05-23
标 题 :Direct synthesis of improved superhydrophobic carbon nitride co-products, and improved superhydroppbic carbon nitride co-products thereof
发明人:LY THUC HUE; THI QUOC HUY; Man Ping
权利人:UNIV CITY HONG KONG
摘要:The present invention is concerned with a method of direct synthesis of co-products of at a first co-product and a second co-product. The first co-product is superhydrophilic carbon nitride thin film and the second co-product is superhydrophilic carbon nitride powder. The method has a step of using a guanidine carbonate salt as a precursor material. The present invention is also concerned with carbon nitride co-products. The carbon nitride co-products has a first co-product of superhydrophilic carbon nitride thin film and a second co-product of superhydrophilic carbon nitride powder. The superhydrophilic carbon nitride thin film has chemical formula of CN x , wherein x is 0.86-1.04, and the superhydrophilic carbon nitride powder has a chemical formula of g-C 3 N 4 .

专利号:US-2023278888-A1
优先权日:2022-03-07
标题 :Accelerated Synthesis of Nickle-Rich Cathode Materials Using Flame-Assisted Spray Pyrolysis
发明人:DENG SILI; ZHANG JIANAN; MULDOON VALERIE L
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Methods of synthesis of nickel-rich cathode materials can include preheating droplets, decomposing the droplets in a burner, collecting solid particles, and calcinating the solid particles.

专利号:US-2025215608-A1
优先权日:2022-03-07
标 题:Synthesis of single-crystal nickel-rich cathode materials using flame-assisted spray pyrolysis
发明人:DENG SILI; ZHANG JIANAN; MULDOON VALERIE L
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A method of synthesis of single crystal nickel-rich cathode materials can include preparing a precursor solution by dissolving lithium nitrate, nickel nitrate, manganese nitrate, and cobalt nitrate in water, aerosolizing the solution of a) in a stream of air using an ultrasonic sprayer, preheating the resulting droplets, premixing the droplets with methane, decomposing the droplets by passing through a co-flow burner, depositing solid particles on a filter, and calcinating the solid particles in a furnace in oxygen to produce a single crystal cathode material.
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合成参考文献


参考文献:10.1110/ps.04820104
摘要:Tatko CD, Waters ML. Investigation of the nature of the methionine-pi interaction in beta-hairpin peptide model systems. Protein Sci. 2004 Sep;13(9):2515–22.
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