CAS: 222036-66-0; 5-Aminoisoindolin-1-One

上下游产品

CAS号110568-64-4 6-硝基-异吲哚啉-1-酮 | CAS号2518-24-3 3-氨基邻苯二甲酰亚胺 | CAS号1113057-04-7 ethyl 4-amino-2... | CAS号62621-09-4 2-甲基-4-硝基苯甲酸甲酯 | CAS号1975-51-5 2-甲基-4-硝基苯甲酸 | CAS号133446-99-8 2-(溴甲基)-4-硝基苯甲酸甲酯 | CAS号552330-86-6 5-溴-1-异吲哚酮

📜3-氨基邻苯二甲酰亚胺置于palladium-Carbon 甲烷磺酸体系中,用 甲醇,(2S)-N-Methyl-1-Phenylpropan-2-Amine Hydrate,二氯甲烷,三氟乙酸 用作溶剂,化学反应生成5-氨基-2,3-二氢异吲哚-1-酮
参考文献:Substituted Oxidole Derivatives As Protein Tyrosine And As Protein Serine/threonine Kinase Inhibitors
标题:Substituted Oxidole Derivatives As Protein Tyrosine And As Protein Serine/threonine Kinase Inhibitors
摘要:本发明总体上涉及新颖的取代吲哚化合物和组合物.这类化合物和组合物作为治疗药物,在治疗通过抑制或拮抗蛋白激酶激活的信号通路而缓解的疾病或状况方面具有效用.特别是,本发明涉及一系列取代吲哚化合物,这些化合物表现出蛋白酪氨酸激酶和蛋白丝氨酸/苏氨酸激酶的抑制作用,并且可用于通过抑制这些激酶来抑制肿瘤生长,以及保护接受化疗的患者免受化疗引起的脱发.

专利信息

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.