CAS: 21087-98-9; 8-Methoxy-3,3,5-Trimethyl-3,11-Dihydropyrano[3,2-A]Carbazole

上下游产品

6-hydroxygirinimbine 3-(tert-butyldiphenylsilyloxy)-4-methylaniline 3-(tert-butyldiphenylsilyloxy)-N-(4-methoxyphenyl)-4-methylaniline 2-(tert-butyldiphenylsilyloxy)-6-methoxy-3-methyl-9H-carbazole6-methoxy-3',3',3,9-tetramethylpyrano[3,2-a]carbazole

📜(4-溴苯氧基)(2-甲基-2-丙基)二苯基硅烷置于titanium(Iv) Isopropylate,Tris-(Dibenzylideneacetone)Dipalladium(0),四丁基氟化铵,Copper Diacetate,Palladium Diacetate,三溴化硼,Sodium Hydride,N,N-二甲基甲酰胺,Sodium T-Butanolate,2-二环己膦基-2'-(N,N-二甲胺)-联苯体系中,用 四氢呋喃,二氯甲烷,N,N-二甲基甲酰胺,甲苯 用作溶剂,化学反应 66.92H,反应生成3,11-二氢-8-甲氧基-3,3,5-三甲基吡喃并[3,2-A]咔唑
参考文献:Synthesis Of The Pyrano[3,2-A]Carbazole Alkaloids Koenine,Koenimbine,Koenigine,Koenigicine,And Structural Reassignment Of Mukonicine
标题:Synthesis Of The Pyrano[3,2-A]Carbazole Alkaloids Koenine,Koenimbine,Koenigine,Koenigicine,And Structural Reassignment Of Mukonicine
摘要:Using The Palladium(II)-Catalyzed Oxidative Cyclization Of A Diarylamine And The Annulation Of A Dimethylpyran Ring By Lewis Acid Promoted Reaction With Prenal As Key Steps,The Total Syntheses Of The 6-Oxygenated Pyrano[3,2-A]Carbazole Alkaloids Koenine And Koenimbine,And Of The 6,7-Dioxygenated Pyrano[3,2-A]Carbazole Alkaloids Koenigine And Koenigicine (Koenimbidine,Koenidine) Were Achieved. Moreover,These Studies Led To An Improved Synthetic Route To The 2,6-Dioxygenated Carbazole Alkaloid Glycozolidol. Mukonicine,Originally Published As 6,8-Dimethoxypyrano[3,2-A]Carbazole,Was Found To Be Identical With Koenigicine.
Doi:10.1055/s-0035-1560359