CAS: 20201-24-5; Ethyl 3-Methyl-2-Oxobutanoate

相似化合物

759-05-7 15933-07-0 129025-85-0

上下游产品

tetrachloromethane ethyl α-isopropylacrylate ethyl isopropylglyoxylate oxime ethyl 3,3-dimethyl-oxirane-2-carboxylate3-methyl-2-ketobutanoic acid α-(2,4-dinitro-phenylhydrazono)-isovaleric acid ethyl ester propanoateethyl (E)-2-2-(pyridin-2'-yl)phenylhydrazonopropanoate (Z)-(S)-5-tert-Butoxycarbonylamino-6-cyclohexyl-2-isopropyl-4-oxo-hex-2-enoic acid ethyl ester

缬氨酸乙酯置于magnesium Bromide体系中,用 二氯甲烷,水 用作溶剂,以68%的收率获得3-甲基-2-氧代丁酰乙酯
参考文献:在 Ch2Cl2-H2O 两相系统中,Mgbr2 促进 α-氨基烷酸酯和二芳基/二烷基二硫醚电合成亚硫胺(硫肟).青霉素和头孢菌素的 C(6)/c(7)-磺胺衍生物的直接制备
标题:在 Ch2Cl2-H2O 两相系统中,Mgbr2 促进 α-氨基烷酸酯和二芳基/二烷基二硫醚电合成亚硫胺(硫肟).青霉素和头孢菌素的 C(6)/c(7)-磺胺衍生物的直接制备
摘要:在 Ch2Cl2-h2O-mgbr2-(pt 电极)系统中通过电解将 α-氨基链烷酸酯和二芳基或二烷基二硫化物直接转化为相应的亚磺亚胺及其在 C(6)/c(7)-氨基亚磺酰化中的应用描述了青霉素和头孢菌素.
Doi:10.1246/cl.1984.1823

专利信息

专利号:US-8153839-B2
优先权日:2005-09-14
标题:Method for synthesis of keto acids or amino acids by hydration of acetylene compound
发明人：OGO SEIJI; FUKUZUMI SHUN-ICHI
权利人:OGO SEIJI; FUKUZUMI SHUN-ICHI; JAPAN SCIENCE & TECH AGENCY
摘要:An object of the present invention is to provide a method for synthesis of keto acids by hydration of an acetylene compound (acetylene-carboxylic acids) under mild conditions free from harmful mercury catalysts and a method for synthesis of amino acids from acetylene-carboxylic acids in a single container (one-pot or tandem synthesis). In one embodiment of the method according to the present invention for synthesis of keto acids, acetylene-carboxylic acids is hydrated in the presence of a metal salt represented by General Formula (1), n nwhere M 1 represents an element in Group VIII, IX, or X of the periodic table, and X 1 , X 2 , or X 3 ligand represents halogen, H 2 O, or a solvent molecule, and k represents a valence of a cation species, and Y represents an anion species, and L represents a valence of the anion species, and each of K and L independently represents 1 or 2, and k×m=L×n.

专利号:US-8044173-B2
优先权日:2005-09-13
标 题 :Asymmetric synthesis of peptides
发明人：HARWOOD LAURENCE M; YAN RAN
权利人:UNIV READING
摘要:A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemisation, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerisation.

专利号:US-8399612-B2
优先权日:2005-09-13
标 题 :Asymmetric synthesis of peptides
发明人：HARWOOD LAURENCE M; YAN RAN
权利人:HARWOOD LAURENCE M; YAN RAN; UNIV READING
摘要:A process comprising substitution of an acceptor molecule comprising a group —XC(O)— wherein X is O, S, or NR 8 , where R 8 is C 1-6 alkyl, C 6-12 aryl or hydrogen, with a nucleophile, wherein the acceptor molecule is cyclised such that said nucleophilic substitution at —XC(O)— occurs without racemization, is provided. This process has particular application for the production of a peptide by extension from the activated carboxy-terminus of an acyl amino acid residue without epimerization.

专利号:US-7517828-B2
优先权日:2003-04-25
标 题 :Chiral broensted acid catalyst for asymmetric synthesis and method of asymmetric synthesis with the catalyst
发明人：AKIYAMA TAKAHIKO
权利人:TOAGOSEI CO LTD
摘要:A compound usable as an asymmetric synthesis catalyst which can be easily synthesized without using any metal such as a lanthanoid group element; a method of asymmetric synthesis with the compound; and a chiral compound obtained by the asymmetric synthesis method. A Broensted acid is used as a catalyst in asymmetric synthesis, the chiral Broensted acid being represented by formula (1) below or formula (3) below. The asymmetric synthesis method employs the catalyst. Asymmetric synthesis with the catalyst gives a chiral compound.

专利号:US-7579487-B2
优先权日:2004-05-11
标 题 :Process for making N-sulfonated-amino acid derivatives
发明人：DREHER SPENCER D; IKEMOTO NORIHIRO; SHULTZ C SCOTT; WILLIAMS J MICHAEL
权利人:MERCK & CO INC
摘要:This invention relates to a process for preparing optically active α-amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries