CAS: 1891-90-3; 4-(Trifluoromethyl)Benzamide

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CAS号329-15-7 对三氟甲基苯甲酰氯 | CAS号201230-82-2 carbon monoxide | CAS号402-43-7 对溴三氟甲苯 | CAS号455-18-5 对三氟甲基苯腈 | CAS号349-95-1 4-(三氟甲基)苄醇 | CAS号455-19-6 对三氟甲基苯甲醛 | CAS号66046-34-2 N-[[4-(trifluor... | CAS号455-13-0 4-碘三氟甲苯 | CAS号32857-62-8 4-(三氟甲基)苯乙酸 | CAS号91888-96-9 N-叔丁基-4-(三氟甲基)苯甲酰胺 | CAS号3300-51-4 对三氟甲基苄胺 | CAS号455-18-5 对三氟甲基苯腈 | CAS号72505-21-6 4-三氟甲基硫代苯甲酰胺 | CAS号141819-91-2 2-(5-甲基-2-(4-(三... | CAS号1548-13-6 4-(三氟甲基)异氰酸苯酯 | CAS号65017-76-7 N-methyl-4-(tri... | CAS号851224-79-8 5-[4-(trifluoro... | CAS号851224-80-1 ethyl 3-(4-(tri... | CAS号851224-81-2 (3-[4-(TRIFLUOR...

📜对三氟甲基苯腈置于fac-[(Co)3Mn(Ipr2P(Ch2)2Pipr2)(Triflato)],水体系中,用 四氢呋喃 用作溶剂,化学反应 18.0H,以88%的收率获得4-(三氟甲基)苯甲酰胺
参考文献:含有i Pr 2 P(ch 2)2 P I Pr 2配体的 Mn(i)有机金属,用于芳族腈的催化水合作用†
标题:含有i Pr 2 P(ch 2)2 P I Pr 2配体的 Mn(i)有机金属,用于芳族腈的催化水合作用†
摘要:报道了由锰分子化合物催化的芳族腈均匀水合的第一个例子.合成了mn(i)有机金属fac-[(co)3 Mn(dippe)(z)] 1-N X 1-N(n = 0,1; Z = Br,Otf,Phcn; X = Otf)表征,并研究了它们的反应性.将种类fac-[(co)3 Mn(dippe)(otf)](2)用作基准苯甲腈(2 Mol%2,Thf / H 2)选择性水合的催化剂前体o 1:2 V / V,18 H,100oc)产生苯甲酰胺,分离产率为90%.将一系列(杂)芳族腈水合以合成相应的酰胺,产率非常好(88-94%).同位素标记研究认为质子转移是决定速率的步骤.
Doi:10.1039/c8Cy00416A

专利信息

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:WO-2012014114-A1
优先权日:2010-07-30
标 题:Matrix metalloproteinase inhibitors
发明人：KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
权利人:RANBAXY LAB LTD; KHERA MANOJ KUMAR; SATTIGERI JITENDRA; SATTIGERI VISWAJANANI; YADAV NEERAJ KUMAR; KUMAR KEWAL; RAUF ABDUL REHMAN ABDUL; CLIFFE IAN A; BHATNAGAR PRADIP KUMAR; RAY ABHIJIT; SRIVASTAVA PUNIT; DASTIDAR SUNANDA GHOSH
摘要:The present invention relates to certain hydroxy propionic acid derivatives and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over activation of a matrix metalloproteinase using the compounds.

专利号:US-6797820-B2
优先权日:1999-12-17
标 题:Succinate compounds, compositions and methods of use and preparation
发明人：PATEL DINESH; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI-JIE; YUAN ZHENGYU
权利人:VICURON PHARM INC
摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:CN-110343087-B
优先权日:2019-07-11
标题:Synthesis of isoindolinone derivatives and preparation method thereof