CAS: 17068-56-3; 1,3-Diacetoxy-1,1,3,3-Tetrabutyldistannoxane

专利信息

专利号:US-6939962-B2
优先权日:2000-07-31
标题:Method for the synthesis of sucrose-6-esters
发明人：CLARK JASON D; LEMAY JR RICHARD R
权利人:TATE & LYLE PLC
摘要:There is described a process for the synthesis of a sucrose-6-ester comprising: (a) reacting a mixture comprising sucrose and a polar aprotic solvent with an organotin-based acylation promoter, while adding a solvent capable of removing water by co-distillation, and removing water by co-distillation, to afford a first reaction mixture which is substantially free from water, followed by (b) adding a carboxylic anhydride to said first reaction mixture to afford a second reaction mixture, and maintaining said second reaction mixture at a temperature and for a period of time sufficient to produce a sucrose-6-ester, characterised in that step (a) is performed at a temperature of from 85 to 125° C. and at a pressure of from 20 to 80 kPa. In the most preferred embodiment, the polar aprotic solvent is DMF, the solvent capable of removing water by co-distillation is cyclohexane, the organotion-based acylation promoter is a 1,3-diacyloxy-1,1,3,3-tetrabutyldistannoxane, and step (a) is performed at approximately 97° C., and approximately 50 kpa, until the weight ratio of tin to water in the first reaction mixture is greater than about 26, when the tin content is measured by X-Ray Fluoresence Analyzer, and the water content is measured by the Karl-Fischer method.

专利号:US-2003158404-A1
优先权日:2000-07-31
标题:Method for the synthesis of sucrose-6-esters

专利号:AU-2008204386-A1
优先权日:2007-01-09
标 题 :Method for the synthesis of sucrose-6-esters

专利号:EP-1305326-B1
优先权日:2000-07-31
标 题 :An improved method for the synthesis of sucrose-6-esters

专利号:EP-1305326-A1
优先权日:2000-07-31
标题 :An improved method for the synthesis of sucrose-6-esters

专利号:EP-2102220-A1
优先权日:2007-01-09
标 题 :Method for the synthesis of sucrose-6-esters