CAS: 16755-07-0; Showdomycin

该化合物是一种化学修改的核糖激素衍生物,其成分为一种与核糖核酸基体合成的阳性组,具有与核糖核酸基体的共聚物的共聚物,在生物合成和交叉应用中特别宝贵,因为使用硫柳汞基体的雄性组体具有活性,从而能够选择性地附着于,蛋白质和其他生物分子中的细胞残渣.其核糖核酸基体骨骼能确保与核糖基系统兼容性,使其对核糖核酸基体的标签或功能化有用.该产品具有高度的特性,在生理条件下具有稳定性,并且具有高效的反动能学,成为化学生物学,药物开发和材料科学研究人员的首选.建议在惰性条件下进行适当的处理,以保持再活性.

结构式图片

上下游产品

2,3-O-Isopropylidene-N-(Triphenylmethyl)Showdomycin 99885-70-8
3-[(3As,4S,6R,6Ar)-6-[[tert-Butyl(Diphenyl)Silyl]Oxymethyl]-2,2-Dimethyl-3A,4,6,6A-Tetrahydrofuro[3,4-D][1,3]Dioxol-4-Yl]Pyrrole-2,5-Dione 170897-53-7

合成工艺路线路线简述

    📜5-O-三苯甲基-2,3-O-异亚丙基-D-呋喃核糖置于ammonium Hydroxide,18-冠醚-6,乙酸酐,二甲基亚砜,三氟乙酸体系中,用 甲醇,氯仿,二甲基亚砜,乙腈 用作溶剂,化学反应 28.0H,反应生成3-Beta-D-呋喃核糖基吡咯-2,5-二酮
    参考文献:Katagiri,Nobuya; Haneda,Toru; Takahashi,Naoko,Heterocycles,1984,Vol. 22,# 10,P. 2195-2198
    标题:Katagiri,Nobuya; Haneda,Toru; Takahashi,Naoko,Heterocycles,1984,Vol. 22,# 10,P. 2195-2198

    海关参考信息

    专利信息


    专利号:WO-9517903-A1
    优先权日:1993-12-28
    标 题:Modular design and synthesis of oxazolone-derived molecules
    发明人:HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
    权利人:ARQULE PARTNERS L P; HOGAN JOSEPH C JR; CASEBIER DAVID; FURTH PAUL; TU CHENG
    摘要:The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recognition agents useful in the design and synthesis of drugs, and have applications in separations and materials science.

    专利号:US-5118802-A
    优先权日:1983-12-20
    标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
    发明人:SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
    权利人:CALIFORNIA INST OF TECHN
    摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

    专利号:WO-9636627-A1
    优先权日:1995-05-19
    标 题 :Collection of activated glycoside compounds and their biological use
    发明人:ANDERSON MARK BRIAN; MUSSER JOHN H
    权利人:GLYCOMED INC
    摘要:The present invention relates to the field of combinatorial carbohydrate chemistry and involves the modification of organic molecules and/or the synthesis of large numbers of products comprising carbohydrate and/or glycominetic entities. More specifically, the present invention relates to activated carbon glycosides useful for the modification of organic molecules by incorporation of carbohydrate units, providing the synthesis of large numbers of products having novel chemical characteristics. The present invention further relates to methods for the generation of chemical compounds comprising carbon glycosides. Methods are disclosed to provide large arrays of molecules and to identify species that act as agonists or antagonists of various biological, chemical, and other activities.

    专利号:US-5118800-A
    优先权日:1983-12-20
    标 题 :Oligonucleotides possessing a primary amino group in the terminal nucleotide
    发明人:SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
    权利人:CALIFORNIA INST OF TECHN
    摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

    专利号:US-5015733-A
    优先权日:1983-12-20
    标题 :Nucleosides possessing blocked aliphatic amino groups
    发明人:SMITH LLOYD M; FUND STEVEN; KAISER JR ROBERT J
    权利人:CALIFORNIA INST OF TECHN
    摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieites may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

    专利号:WO-9505391-A1
    优先权日:1993-08-18
    标 题 :Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
    发明人:CONRAD MICHAEL J
    权利人:CHROMAGEN INC
    摘要:Structural analogs of the six non-fluorescent N-nucleosides commonly found in RNA and DNA, which are inherently fluorescent under physiological conditions, are identified and methods for their preparation provided. Such analogs may be incorporated into DNA and/or RNA oligonucleotides via either enzymatic or chemical synthesis to produce fluorescent oligonucleotides having prescribed sequences. Such analogous sequences may be identical to, or the analogous complement of, template or target DNA or RNA sequences to which the fluorescent oligonucleotides can be hybridized. Methods of preparing either RNA or DNA oligonucleotide probes of the invention, intermediates used in such methods, and methods of using the probes of the invention in oligonucleotide amplification, detection, identification, and/or hybridization assays are also provided.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Palmu K, Rosenqvist P, Thapa K, Ilina Y, Siitonen V, Baral B, Mäkinen J, Belogurov G, Virta P, Niemi J, Metsä-Ketelä M. Discovery of the Showdomycin Gene Cluster from Streptomyces showdoensis ATCC 15227 Yields Insight into the Biosynthetic Logic of C-Nucleoside Antibiotics. ACS Chem Biol. 2017 Apr 27. doi: 10.1021/acschembio.7b00078. [Epub ahead of print] doi: 10.1021/acs.jmedchem.5b01157. Epub 2015 Oct 29. Review. doi: 10.1002/chem.201405009. Epub 2015 Jan 21. doi: 10.1021/ja909150y.
    9: Kean EL, Wei Z. Stimulation as well as inhibition by antibiotics of the formation of GlcNAc-lipids of the dolichol pathway. Glycoconj J. 1998 Apr;15(4):405-14.
    11: Mumper MW, Aurenge C, Hosmane RS. "Slim" nucleosides and nucleotides. I. Synthetic, structural and biophysical investigations of showdomycins. J Biomol Struct Dyn. 1994 Apr;11(5):1107-31.

    合成参考文献


    参考文献:10.1016/j.bbrc.2023.08.050
    摘要:Ikeda Y, Davis MI, Sumita K, Zheng Y, Kofuji S, Sasaki M, Hirota Y, Pragani R, Shen M, Boxer MB, Takeuchi K, Senda T, Simeonov A, Sasaki AT. Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells. Biochemical and Biophysical Research Communications. 2023 Oct;679():116–21. doi: 10.1016/j.bbrc.2023.08.050.
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