CAS: 14046-55-0; 1-(3,4-Dimethoxyphenyl)-2-Methylpropan-1-One

该化合物是一种有机化合物,其特征为氯酮功能组和一个替代芳香环,该化合物的特征为:丙酮基质与一个甲基组,3,4-二甲基氧基苯替代体,其独特的化学特性有3,4-二甲基氧基苯基替代体.该化合物一般无色可粉黄液体或固体,视具体情况和纯度而定.甲基氧基组的存在会增加其在有机溶剂中的溶解性,并可能影响其再活动及与生物系统的相互作用.该化合物对有机合成感兴趣,并可作为各种药品或农用化学品生产的中间体.其稳定性和再活动可能受温度和其他试剂的存在等因素的影响.与许多有机化合物一样,在处理时应采取安全防范措施,因为如果浸入或吸入,可能会对健康造成危害.

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物理性质

MSDS等安全信息

欧盟法规

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上下游产品

1,2-dimethoxybenzene isobutyryl chloride isobutyric Acid 2-Methylpropionic anhydride 5-(3,4-dimethoxy-phenyl)-4-methyl-[1,2]dithiol-3-thione 4-isobutyl-1,2-dimethoxybenzene α-bromo-α-methyl-3,4-dimethoxyacetophenone 1-(3,4-dimethoxyphenyl)-2,2-dimethylpropan-1-one

合成工艺路线路线简述

    📜1-(3,4-二甲氧基苯基)-2-甲基-1-丙醇置于jones Reagent体系中,化学反应生成3',4'-二甲氧基异苯丁酮
    参考文献:含p(o)h化合物的银促进的γ,δ-不饱和肟酯的级联自由基环化:磷酸化的吡咯啉的合成.
    标题:含p(o)h化合物的银促进的γ,δ-不饱和肟酯的级联自由基环化:磷酸化的吡咯啉的合成.
    摘要:对于第一个由银促进的γ,δ-不饱和肟酯的亚氨基磷酸化反应,实现了级联自由基环化反应,这为逐步获得经济且氧化还原中性的途径提供了一种经济高效且氧化还原中性的途径,从而能够以优异的收率获得各种磷酸化的吡咯啉.此外,通过脱氧过程获得了具有吡咯啉基序的新的庞大的三价膦配体.
    Doi:10.1039/c9Cc08124K

    海关参考信息

    专利信息


    专利号:US-5097058-A
    优先权日:1987-04-08
    标题:Process for the synthesis of the α-(-methyl-ethyl)-3,4-dimethoxybenzene-acetonitrile
    发明人：CANNATA VINCENZO; TAMERLANI GIANCARLO; ZAGNONI GRAZIANO
    权利人:ALFA WASSERMANN SPA
    摘要:New process for the synthesis of the α-(1-m.ethylethyl)-3,4-dimethoxyacetonitrile of formula (I): ##STR1## which is known as an intermediate in the synthesis of the drug internationally known as verapamil. The process starts from the isobutyryl-3,4-dimethoxybenzene of formula (II): ##STR2## which, by means of the Darzens condensation, gives an epoxyester which, by alkaline hydrolysis and subsequent decarboxylation, gives the α-(1-methylethyl)-3,4-dimethoxybenzeneacetaldehyde. This product is reacted with hydroxylamine to obtain the corresponding oxime that, by dehydration, gives the nitrile of formula I.

    专利号:PT-87187-B
    优先权日:1987-04-08
    标 题:PROCESS FOR THE SYNTHESIS OF ALPHA- (1-METHYL-ETHYL) -3,4-DIMETOXY-BENZENE-ACETONITRYL

    专利号:EP-0285890-A2
    优先权日:1987-04-08
    标 题 :New process for the synthesis of the alpha-(1-methylethyl)-3,4-dimethoxybenzene-acetonitrile

    专利号:CA-1327048-C
    优先权日:1987-04-08
    标 题 :Process for the synthesis of the .alpha.-(1-methylethyl)-3,4-dimethoxybenzene-acetonitrile

    专利号:AU-605571-B2
    优先权日:1987-04-08
    标 题 :New process for the synthesis of the alpha-(1-methyl-ethyl)- 3,4-dimethoxybenzene-acetonitrile

    专利号:IE-881033-L
    优先权日:1987-04-08
    标题 :New process for the synthesis of the¹Ó-(1-methylethyl)-3,4-dimethoxybenzeneacetonitrile

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    主要参考文献

    参考标题:An Efficient Synthesis Of Highly Substituted Indanones And Chalcones Promoted By Superacid
    作者:Amrita Das,Alavala Gopi Krishna Reddy,Jonnada Krishna,Gedu Satyanarayana
    摘要:A Superacid Promoted One-Pot Method Was Developed For The Efficient Synthesis Of Indanones. This Process Enabled The Formation Of A Dual C-C Bond Between The Aryl Isopropyl Ketones And Benzaldehydes. Interestingly, When The Reaction Was Performed Between Acetophenones And Benzaldehydes, It Was Impeded After The Aldol Condensation And Resulted In The Corresponding Chalcones.

    合成参考文献


    摘要:Journal of Medicinal Chemistry., 7(178), 1964
    摘要:S109 | PARCEDC | List of 7074 potential endocrine disrupting compounds (EDCs) by PARC T4.2 | DOI:10.5281/zenodo.10944198
    参考文献:10.1021/np9805443
    摘要:Zacchino SA, López SN, Pezzenati GD, Furlán RL, Santecchia CB, Muñoz L, Giannini FA, Rodríguez AM, Enriz RD. In Vitro Evaluation of Antifungal Properties of Phenylpropanoids and Related Compounds Acting Against Dermatophytes. J. Nat. Prod. 1999 Sep 18;62(10):1353–7. doi: 10.1021/np9805443.
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