戊腈置于盐酸,异丙醚体系中,化学反应生成原戊酸三甲酯 参考文献:Ketene Acetals. Xvii. The Alkylation And Acylation Of Substituted Ketene Acetals 标题:Ketene Acetals. Xvii. The Alkylation And Acylation Of Substituted Ketene Acetals 摘要: Doi:10.1021/ja01214A015
专利号:US-8642766-B2 优先权日:2008-05-05 标题 :Synthesis of (+) cortistatin A and related compounds 发明人:SHENVI RYAN A; GUERRERO CARLOS A; SHI JUN; LI CHUANG-CHUANG; BARAN PHIL S 权利人:SHENVI RYAN A; GUERRERO CARLOS A; SHI JUN; LI CHUANG-CHUANG; BARAN PHIL S 摘要:An in vitro synthesis of (+) cortistatin A from readily available precursors is disclosed, as are the syntheses of related 17-aryl substituted compounds, the 17-aryl substituted compounds themselves and novel compounds useful in their preparation.
专利号:US-8115002-B2 优先权日:2006-09-20 标 题:Preparation of substituted morphinan-6-ones and salts and intermediates thereof 发明人:WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W 权利人:WANG PETER X; MOSER FRANK W; CANTRELL GARY L; GROTE CHRISTOPHER W; MALLINCKRODT LLC 摘要:The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.
专利号:US-7741492-B2 优先权日:2005-02-28 标题:Method for obtaining a pharmaceutically active compound (Irbesartan) and its synthesis intermediate 发明人:HUGUET CLOTET JOAN; DALMASES BARJOAN PERE 权利人:INKE SA 摘要:It is provided a method for obtaining Irbesartan polymorph A, with few synthesis steps, by coupling the intermediate of formula (II) with the compound of formula (III), neutralising one of its alkaline salts in an aqueous medium and recrystallising the crude product obtained. The utilisation of said method obviates protection and deprotection of the tetrazole ring and is therefore of considerable interest for obtaining Irbesartan on a large industrial scale. The invention also refers to the synthesis intermediate of formula (II).
专利号:US-2002156277-A1 优先权日:2001-04-20 标题 :Synthesis and methods of use of purine analogues and derivatives 发明人:FICK DAVID B; FOREMAN MARK M; GLASKY ALVIN J 摘要:A purine derivative or analogue comprises a 9-atom bicyclic moiety, moiety A, linked through a linker L to a moiety B, where B is a carboxylic acid, a carboxylic acid ester, or a moiety of the structure N(Y 1 )—D, where Y 1 can be one of a variety of substituents, including hydrogen or alkyl, and D is a moiety that enhances the pharmacological effects, promotes absorption or blood-brain barrier penetration of the derivative or analogue. The moiety A has a six-membered ring fused to a five-membered ring. The moiety A can have one, two, or three nitrogen atoms in the five membered ring and has two nitrogen atoms in the six-membered ring. The moiety A can be a purine moiety. The moiety B can be one of a variety of moieties, including moieties having nootropic activity or other biological or physiological activity.
专利号:CA-2723689-A1 优先权日:2008-05-05 标 题:Synthesis of (+) cortistatin a and related compounds
专利号:US-2011060140-A1 优先权日:2008-05-05 标题:Synthesis of (+) cortistatin a and related compounds