CAS: 126689-01-8; 2-Cyclopropyl-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane

相似化合物

411235-57-9 126689-04-1 1309366-00-4

上下游产品

CAS号4333-56-6 环丙溴 | CAS号73183-34-3 双戊酰二硼

频哪醇,以 四氢呋喃 用作溶剂,化学反应 1.0H,以91%的收率获得环丙基硼酸频哪醇酯
参考文献:一锅法合成硼胺类化合物的工艺
标题:一锅法合成硼胺类化合物的工艺
摘要:本发明公开了一锅法合成硼胺类化合物的工艺:将无水溶剂,溴代物rbr和xby2三者混合后,缓慢滴入到含有金属锂的无水溶剂中,滴加过程中维持温度在‑20~20°C,待反应引发后,将其余的全部加入完毕,随后维持‑20~40oc反应3‑8H,分离后得到rby2.该中间体可以加酸水解成有机硼酸,与二醇反应生成硼酸酯,或是与芳基卤代物直接进行偶联反应.该工艺操作简单,避免了超低温反应以及锂化物稳定性对溶剂的依赖,副产物少,反应收率高,适合工业化放大,有利于提高产品的核心竞争力.

专利信息

专利号:US-11512097-B2
优先权日:2019-11-25
标题 :Heterocyclic compounds as Delta-5 desaturase inhibitors and methods of use
发明人：ALLEN JENNIFER R; BELTRANI MICHELA; BOURBEAU MATTHEW P; DAMYANOVA TEODORA P; LINGARD IAIN; MINATTI ANA E; VINCETTI PAOLO
权利人:AMGEN INC
摘要:The present disclosure provides compounds useful for the inhibition of Delta-5 Desaturase (“D5Dâ€?). The compounds have a general Formula I n nwherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a metabolic or cardiovascular disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人：MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.