CAS: 121521-90-2; (R)-2-(((2S,3S)-4-((E)-3-((R)-1-Carboxy-2-(3,4-Dihydroxyphenyl)Ethoxy)-3-Oxoprop-1-En-1-yl)-2-(3,4-Dihydroxyphenyl)-7-Hydroxy-2,3-Dihydrobenzofuran-3-Carbonyl)Oxy)-3-(3,4-Dihydroxyphenyl)Propanoic Acid

该化合物是一种从草原Salvia Miltiorrhiza根根根提取的强效多酚化合物,具有强效抗氧化剂和抗炎特性,使其成为制药和营养疗法应用中有价值的成分. 它的主要优势包括它有能力对自由基,抑制小板块聚集和调节免疫反应,有助于其在心血管和...

英文名称(R)-2-(((2S,3S)-4-((E)-3-((R)-1-Carboxy-2-(3,4-Dihydroxyphenyl)Ethoxy)-3-Oxoprop-1-En-1-yl)-2-(3,4-Dihydroxyphenyl)-7-Hydroxy-2,3-Dihydrobenzofuran-3-Carbonyl)Oxy)-3-(3,4-Dihydroxyphenyl)Propanoic Acid
中文名称丹酚酸 B
IUPAC名称(R)-2-(((2S,3S)-4-((E)-3-((R)-1-carboxy-2-(3,4-dihydroxyphenyl)ethoxy)-3-oxoprop-1-en-1-yl)-2-(3,4-dihydroxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carbonyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid
其它别名Dan Shen Suan B; Lithospermic Acid B; (R)-2-(((2S,3S)-4-((E)-3-((R)-1-Carboxy-2-(3,4-Dihydroxyphenyl)Ethoxy)-3-Oxoprop-1-En-1-yl)-2-(3,4-Dihydroxyphenyl)-7-Hydroxy-2,3-Dihydrobenzofuran-3-Carbonyl)Oxy)-3-(3,4-Dihydroxyphenyl)Propanoicacid; Danfensuan B
CAS编号121521-90-2
MFCD编号:MFCD07779133
FDA UNII编号:C1GQ844199
分子式:C36H30O16
分子量:718.62
产品CID: 296598
同类组份化合物CAS122021-74-3 (magnesium)121521-90-2 (free acid)
产品分类天然产物 → 酚类

相似结构搜索
产品信息参考
InChIKey: SNKFFCBZYFGCQN-VWUOOIFGSA-N
SNKFFCBZYFGCQN-VWUOOIFGSA-N…
计算化学: 氢键受体数16.0氢键供体数9.0可旋转键数14.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H315-H319-H335
防范说明P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
安全声明24/25
WGK Germany3

上下游产品

ammonium-potassium lithospermate Bammonium-potassium lithospermate B dipotassium salt of lithospermic acid B calcium salt of lithospermic acid B dimethyl heptamethyllithospermate B

合成工艺路线路线简述

Magnesium Lithospermate B置于ir 120B Resin (H(1+) Form)体系中,化学反应生成丹酚酸 B
参考文献:Magnesium And Ammonium-Potassium Lithospermates B,The Active Principles Having A Uremia-Preventive Effect From Salvia Miltiorrhiza.
标题:Magnesium And Ammonium-Potassium Lithospermates B,The Active Principles Having A Uremia-Preventive Effect From Salvia Miltiorrhiza.
摘要:从丹参中分离出了对尿毒症症状有改善作用的活性成分,并将其命名为石炭酸镁(1)和石炭酸铵钾(2).此外,还根据化学和光谱数据确定了石炭酸的立体结构,该结构一直未得到澄清.
Doi:10.1248/cpb.37.340

专利信息

专利号:CN-115197851-A
优先权日:2022-05-30
标题:Penicillium difficile and its use in regulating the synthesis of tanshinones in the roots of Salvia miltiorrhiza

专利号:CN-115197851-B
优先权日:2022-05-30
标题 :Penicillium rugosa and its use in regulating the synthesis of tanshinone components in the root of Danshen

专利号:CN-115612114-A
优先权日:2021-07-14
标题:Method and application of copolymer film and its enzymatic self-assembly synthesis

其他信息查阅

武汉华玖医药科技有限公司

网址: http://www.whhjpharm.com
企业联系电话：18120446293👤
地址:武汉市东西湖区泾河办事处陈家岭189号

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主要参考文献

1: Xiuli W, Wei G, Mao S. Pharmacokinetic investigation on interaction between hydrophilic lithospermic acid B and lipophilic tanshinone IIA in rats: an experi- mental study. J Tradit Chin Med. 2015 Apr;35(2):206-10. doi: 10.1016/j.fitote.2013.08.009. Epub 2013 Aug 23. doi: 10.1002/jssc.201600368. Epub 2016 Sep 6. doi: 10.1016/j.taap.2011.01.018. Epub 2011 Feb 2. doi: 10.1016/j.ultsonch.2011.12.017. Epub 2012 Jan 3. doi: 10.1016/j.chroma.2011.05.048. Epub 2011 May 20. doi: 10.1016/j.talanta.2007.12.045. Epub 2008 Jan 15. Epub 2007 Nov 1. doi: 10.1042/BSR20080124. Epub 2006 Sep 6. Epub 2006 Nov 21. Epub 2007 Jan 9.

合成参考文献

参考文献:10.1093/chromsci/46.2.165
摘要:Gu M, Su Z-G, Janson J-C. One-Step Purification of 3,4-Dihydroxyphenyllactic Acid, Salvianolic Acid B, and Protocatechualdehyde from Salvia miltiorrhiza Bunge by Isocratic Stepwise Hydrogen Bond Adsorption Chromatography on Cross-Linked 12% Agarose. Journal of Chromatographic Science. 2008 Feb 01;46(2):165–8. doi: 10.1093/chromsci/46.2.165.
参考文献:10.4268/cjcmm20110320
摘要:Liu D, Guo L, Huang L, Jin H, Wu L, Zeng Y, Zhang J, Yang Y. [Effects of soil water content on seedlings growth and active ingredients of Salvia miltiorrhiza]. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(3):321–5.
参考文献:10.4268/cjcmm20110411
摘要:Wang Y, Zhu J, Fu S, Zhu L, Zhang Y. [Study on chemical changes of salvianolic acid B and lithospermic acid aqueous under conditions of high temperature and high pressure]. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(4):434–8.
摘要:Liu JG, Ding YR, Yang SL. [Effect of salvianolic acid B on CD14 expression in rats with liver fibrosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Apr;31(4):547–51.
参考文献:10.1016/j.oooo.2012.10.006
摘要:Jiang X, Zhang Y, Yang S, Zhang H, Lu K, Sun G. Efficacy of salvianolic acid B combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013 Mar;115(3):339–44. doi: 10.1016/j.oooo.2012.10.006.