CAS: 103909-75-7; Maxacalcitol

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CAS号917-54-4 甲基锂 | CAS号413571-27-4 3-((S)-1-((1S,3... | CAS号20998-18-9 1-hydroxydehydr... | CAS号111594-61-7 1α,3β-bis[(tert... | CAS号81522-68-1 [3S-(1Z,3a,5b)]... | CAS号192573-35-6 ethyl 3-((S)-1-... | CAS号413571-28-5 ethyl 3-((S)-1-...

在 四丁基氟化铵体系中,用 四氢呋喃 用作溶剂,化学反应 24.0H,以90%的收率获得马沙骨化醇
参考文献:一种马沙骨化醇的制备方法
标题:一种马沙骨化醇的制备方法
摘要:本发明属于药物化学领域,具体涉及一种马沙骨化醇的制备方法.该方法以化合物1为起始原料,经过对甲苯磺酸酯选择性保护二级羟基,在碱的作用下,在甲醇中发生分子内环化反应生成化合物3,3经过烯丙位氧化,选择性保护二级羟基得到化合物5,化合物5在酸作用下打开三元环得到化合物6,化合物6脱保护基得到目标化合物.本发明原料易得,操作简单,步骤短,只有6步反应.

专利信息

专利号:US-2022267266-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol
发明人：DATLA ANUPAMA; NAGRE PRASHANT; TAMORE JAGDISH; PRABHU MANOJKUMAR SADANAND; KADAM SACHIN VASANT
权利人:FERMENTA BIOTECH LTD
摘要:Disclosed herein is an improved and efficient process for synthesis of vitamin D3 and its analogue Calcifediol from Ergosterol. Particularly, the present invention discloses the synthesis of key intermediate 3β-tert-Butyldimethylsilyloxy-22-hydroxy-23,24-bisnorchola-5,7-diene (5), and novel intermediate β-tert-Butyldimethylsilyloxy-22-iodo-23,24-bisnorchola-5,7-diene (9) by a simple and cost effective process. The industrially viable processes for preparation of said intermediate(s) results in providing provitamins with various side chains and the desired products in high yield.

专利号:US-9221753-B2
优先权日:2004-02-03
标题:Process for the synthesis of vitamin D compounds and intermediates for the synthesis of the compounds
发明人：KASHIWAGI HIROTAKA; ONO YOSHIYUKI
权利人:KASHIWAGI HIROTAKA; ONO YOSHIYUKI; CHUGAI PHARMACEUTICAL CO LTD
摘要:An object of the present invention is to provide a process for synthesizing a vitamin D compound by simple procedures at lower costs. n The present invention provides a process for preparing a vitamin D compound and an intermediate thereof, comprising the step of: (a) mixing a ketone or aldehyde, a Wittig reagent, and a base; or (b) mixing a ketone or aldehyde and a Wittig reagent, and then adding a base to the resulting mixture.

专利号:US-6399767-B1
优先权日:1996-09-03
标 题 :Intermediates for the synthesis of vitamin D and steroid derivatives and process for preparation thereof
发明人：HORNE DAVID A; KUBODERA NOBORU; SUZUKI HIROSHI; SHIMIZU HITOSHI
权利人:UNIV COLUMBIA; CHUGAI PHARMACEUTICAL CO LTD
摘要:A process for preparing a compound having structure (I) wherein n is an integer from 1-5; each of R 1 and R 2 independently is optionally substituted C 1 -C 6 alkyl; each of W and X is independently hydrogen or C 1 -C 6 alkyl; Y is O, S or NR 3 where R 3 is hydrogen, C 1 -C 6 alkyl or a protective group; and Z is a CD ring structure, a steroid structure, or a vitamin D structure, each of which optionally having structure (IV) wherein W, X, Y and Z are defined above, in the presence of a base, with a compound having structure (V) or (v′) wherein n, R 1 and R 2 are as defined above, and E is an eliminating group.

专利号:US-2007135394-A1
优先权日:2004-02-03
标题 :Process for the synthesis of vitamin d compounds and intermediates for the synthesis of the compounds

专利号:IL-93896-A
优先权日:1989-03-28
标 题:Medicinal preparations containing the history of vitamin D3 for the suppression of synthesis of the parathyroid hormone and its secretion

专利号:WO-2021005619-A1
优先权日:2019-07-09
标 题 :Improved, cost effective process for synthesis of vitamin d3 and its analogue calcifediol from ergosterol