CAS: 90390-27-5; 3,5-Difluorobenzylamine

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CAS号64248-63-1 3,5-二氟苯甲腈 | CAS号677728-83-5 Benzaldehyde, 3...

3,5-二氟苯甲腈置于fe-Cymacho,氢气体系中,用 异丙醇 作为反应溶剂,100.0 °C,3.0 Mpa 条件下,反应 3.0H,以44%的收率获得产物3,5-二氟苄胺
参考文献:使用铁钳配合物将腈选择性催化加氢为伯胺†
标题:使用铁钳配合物将腈选择性催化加氢为伯胺†
摘要:据报道,用明确定义的fe(pnp Cy)钳配合物2将腈选择性催化氢化为伯胺.该铁夹钳催化剂在相对温和的条件下以高收率显示出优异的催化活性和选择性,可以高产率地还原包括工业相关的己二腈在内的各种腈.
DOI:10.1039/c6Cy00834H

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-2025049791-A1
优先权日:2023-08-03
标题:Synthesis of MEK7 Inhibitors and methods of Use Thereof
发明人：SCHEIDT KARL A; KIM DALTON ROBERT; ORR MEGHAN JO
权利人:UNIV NORTHWESTERN
摘要:Disclosed herein are 4-phenoxypyrimidine compounds and derivatives thereof for use as inhibitors of mitogen-activated protein kinase 7 (MEK7). The disclosed compounds and pharmaceutical compositions thereof may be used in methods for treating a disease or disorder associated with MEK7 activity, including cell proliferative diseases and disorders associated with MEK7 activity, such as cancer.

专利号:US-2006122240-A1
优先权日:2002-11-05
标题 :Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof
发明人：SEMPLE GRAEME; SKINNER PHILIP J; CHERRIER MARTIN C; WEBB PETER; TAMURA SUSAN Y
权利人:ARENA PHARM INC
摘要:The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

专利号:US-9513294-B2
优先权日:2012-12-26
标题:Megastokes amino-triazolyl-BODIPY compounds and applications to live neuron staining and human serum albumin FA1 drug site probing
发明人：CHANG YOUNG-TAE; ER JUN CHENG; LEONG CHERYL KIT MUN; YUN SEONG WOOK; VENDRELL ESCOBAR MARC; TANG MUI KEE
权利人:NAT UNIV SINGAPORE; AGENCY SCIENCE TECH & RES
摘要:A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes for human serum albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.

专利号:JP-2001503782-A
优先权日:1996-11-22
标题 :Method and compound for inhibiting release of beta-amyloid peptide and / or its synthesis

专利号:CN-111909113-A
优先权日:2020-08-05
标 题:Synthesis method of 2-substituted benzothiazole compound under catalyst-free and additive-free conditions