CAS: 90-26-6; 2-Phenylbutyramide

该化合物是属于氨化物类别的有机化合物,其外脊骨与第二个碳相连,具有独特的结构,在室温下,该化合物一般是白色的,非白色的固体,以其在水中的溶解性较低而闻名,同时在有机溶剂中更易溶解. 2-苯丁胺胺胺具有氨化物的典型特征,如形成氢结壳的能力,这可能影响其沸点和熔点.它经常用于有机合成,并可作为生产药品或其他化学化合物的中间体.该苯基的存在还能够产生独特的化学反应和特性,使其在各种化学应用中具有意义.在处理和储存时,应参考安全数据,如任何化学物质.

结构式图片

物理性质

MSDS等安全信息

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CAS号769-68-6 α-苯基丁腈 | CAS号166337-42-4 N-Methoxy-N-met... | CAS号36854-57-6 2-苯基丁酰氯 | CAS号351464-81-8 N-Methoxy-2-phe... | CAS号75-04-7 乙胺 | CAS号103-81-1 2-苯乙酰胺 | CAS号103-80-0 苯乙酰氯 | CAS号90-27-7 2-苯基丁酸 | CAS号57-30-7 苯巴比妥钠 | CAS号50-06-6 苯巴比妥 | CAS号4286-15-1 (S)-(+)-2-苯基丁酸 | CAS号74042-63-0 (R)-2phenylbuty... | CAS号938-79-4 (R)-(-)-2-苯基丁酸 | CAS号90-27-7 2-苯基丁酸 | CAS号2035-94-1 DL-β-乙基苯乙基乙醇 | CAS号34577-88-3 (R)-(-)-2-pheny... | CAS号7463-53-8 2-(4-硝基苯基)丁酸 | CAS号769-68-6 α-苯基丁腈 | CAS号2941-20-0 α-乙基苄胺 | CAS号6326-11-0 2-phenyl-N-(9H-...

合成工艺路线路线简述

  • 769-68-6 = 90-26-6
    反应条件:1.1 Reagents: Water Catalysts: Mercuric Acetate Solvents: Acetic Acid
    标题:Hydration Of Nitriles To Amides Promoted By Mercury(Ii) Acetate In Acetic Acid
    作者:Plummer,B. F.; Menendez,Mercedes; Songster,Michael
    参考文献:Journal Of Organic Chemistry 日期:1989 卷标:54(3) 页码:718-19]

    = 90-26-6
    反应条件:1.1 Reagents: Potassium Tert-Butoxide Catalysts: 2,2′:6′,2′′-Terpyridine,Iridium,Di-μ-Chlorodichlorobis[(1,2,3,4,5-η)-1,2,3,4,5-Pentamethyl-2,4-Cyclopen... Solvents: 2-Methyl-2-Butanol; 5 H,150 °C
    标题:Base-Controlled Chemoselectivity: Direct Coupling Of Alcohols And Acetonitriles To Synthesize α-Alkylated Arylacetonitriles Or Acetamides
    作者:Li,Chen; Bai,Liang; Ge,Min-Tong; Xia,Ai-Bao; Wang,Ying; Et Al
    参考文献:New Journal Of Chemistry 日期:2021 卷标:45(34) 页码:15200-15204]

    769-68-6 = 90-26-6
    反应条件:1.1 Reagents: Sulfuric Acid Solvents: Dichloromethane,Water; Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 8 - 10,Rt
    标题:Biotransformations Of Nitriles Mediated By In Vivo Nitrile Hydratase Of Rhodococcus Erythropolis Atcc 4277 Heterologously Expressed In E. Coli
    作者:Moraes,Maraylla I.; Iglesias,Cesar; Teixeira,Iris S.; Milagre,Humberto M. S.; Giordano,Sonia Rodriguez; Et Al
    参考文献:Results In Chemistry 日期:2023 卷标:5]

    769-68-6 = 90-26-6 [标题:Reaction Conditions
    标题:Enantioselective Hydrolysis Of Nitriles And Amides Using An Immobilized Whole Cell System
    作者:Cohen,Mark A.; Paratt,Julian S.; Turner,Nicholas J.
    参考文献:Tetrahedron: Asymmetry 日期:1992 卷标:3(12) 页码:1543-6]

    17698-12-3 = 90-26-6
    反应条件:1.1 Reagents: Thioacetic Acid,Ammonium Bicarbonate Solvents: Ethanol; 12 H,Rt
    标题:Condition-Controlled O-Acylation And N-O Bond Reduction Of Hydroximic Acids With Thioacetic Acid
    作者:Wang,Risong; Chen,Yifei; Fei,Binjie; Hu,Jiahao; Chen,Jianhui; Et Al
    参考文献:Organic Letters 日期:2023 卷标:25(17) 页码:2970-2974]

    769-68-6 = 90-26-6
    反应条件:1.1 Reagents: Water Catalysts: [1,3-Bis[2,6-Bis(1-Methylethyl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene](1,1,1-... Solvents: Tetrahydrofuran,Water; 6 H,7 Bar,140 °C; 140 °C -> Rt; Rt
    标题:Gold Activation Of Nitriles: Catalytic Hydration To Amides
    作者:Ramon,Ruben S.; Marion,Nicolas; Nolan,Steven P.
    参考文献:Chemistry - A European Journal 日期:2009 卷标:15(35) 页码:8695-8697]

    36854-57-6 = 90-26-6
    反应条件:1.1 Reagents: Ammonium Chloride Solvents: N-Methyl-2-Pyrrolidone; 1 H,120 °C
    标题:Amidation Of Acid Chlorides To Primary Amides With Ammonium Salts
    作者:Li,Zhejian; Gao,Bao; Huang,Hanmin
    参考文献:Youji Huaxue 日期:2018 卷标:38(6) 页码:1431-1436]

    351464-81-8 = 90-26-6
    反应条件:1.1 Reagents: Lithium Catalysts: 4,4′-Bis(1,1-Dimethylethyl)-1,1′-Biphenyl Solvents: Tetrahydrofuran
    标题:Lithium/dtbb-Induced Reduction Of N-Alkoxyamides And Acyl Azides
    作者:Yus,Miguel; Radivoy,Gabriel; Alonso,Francisco
    参考文献:Synthesis 日期:2001 卷标:(6) 页码:914-918]

    769-68-6 = 90-26-6 [标题:Reaction Conditions
    标题:Synthesis Of Amides From Carboxylic Acids And Derivatives
    作者:Ziegler,T.
    参考文献:Science Of Synthesis 日期:2005 卷标:21 页码:43-75]

    769-68-6 = 90-26-6 + 90-27-7
    反应条件:1.1 Solvents: Water; 42 H,Ph 7.4,30 °C
    标题:Chemo- And Enantioselective Hydrolysis Of Nitriles And Acid Amides,Respectively,With Resting Cells Of Rhodococcus Sp. C3Ii And Rhodococcus Erythropolis Mp50
    作者:Effenberger,Franz; Graef,Bernd Walter
    参考文献:Journal Of Biotechnology 日期:1998 卷标:60(3) 页码:165-174
📜Phenobartital Sodium置于sodium Hydroxide体系中,用 水 作为反应溶剂,化学反应 12.0H,反应生成 2-苯基丁酰胺
参考文献:巴比妥酸盐注射液的液相色谱分析.
标题:巴比妥酸盐注射液的液相色谱分析.
摘要:针对苯巴比妥,戊巴比妥和癸巴比妥钠注射液开发了精确,坚固,可指示稳定性的HPLC分析方法.制备了三种巴比妥酸盐的降解产物,并进行了色谱分离,以证明方法的特异性.降解产物还用于证明官方气相色谱方法对戊巴比妥和癸巴比妥钠胶囊的特异性.在通过HPLC分离非对映异构体后,表征了戊巴比妥和癸巴比妥的乙酰脲降解产物.
DOI:10.1002/jps.2600750721

海关参考信息

专利信息


专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2009156465-A1
优先权日:2005-12-30
标题:Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
发明人：SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
权利人:SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
摘要:The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.

专利号:US-2022289684-A1
优先权日:2019-08-29
标 题:Benzimidazole substitution-based phenyl n-butyramide compound and preparation method therefor
发明人：SHEN JINGSHAN; SUN CHANGLIANG; ZHU FUQIANG; ZHANG JUNCHI; LI RUI
权利人:TOPHARMAN SHANGHAI CO LTD; SHANGHAI INST OF MATERIAMEDICA CHINESE ACADEMY OF SCIENCES; TOPHARMAN TANCHENG CO LTD
摘要:The present disclosure relates to a benzimidazole-substituted phenyl-n-butyramide-based compound and the preparation method thereof. The method of the present disclosure avoids nitration reaction and polyphosphoric acid cyclization reaction, and avoids the generation of a large amount of waste acid reaction solution from the source. The synthesis method embodied in the invention has the advantages of simplicity and high efficiency, mild conditions and few pollutants, etc., and is suitable to be developed as a green and sustainable production process.

专利号:US-2006287397-A1
优先权日:2002-04-26
标 题:Dl-hydroxy-alkyl-phenylamides having anticonvulsive activity
发明人：MEZA TOLEDO SERGIO E
权利人:MEZA TOLEDO SERGIO E
摘要:New anticonvulsant compounds were synthesized and they include the compounds: DL-2-hydroxy-2-(3′,5′-bistrifluoromethylphenyl)butyramide, DL-2-hydroxy-2-(4′-trifluoromethylphenyl)butyramide, DL-2-hydroxy-2-(3′,4′-dichlorophenyl)butyramide, DL-2-hydroxy-2-(3′-bromophenyl)butyramide, DL-2-hydroxy-2-(4′-bromophenyl)butyramide, DL-2-hydroxy-2-(3′-nitrophenyl)butyramide, DL-3-hydroxy-3-(3′,4′-dichlorophenyl)pentanamide, DL-3-hydroxy-3-(4′-bromophenyl)pentanamide, DL-4-hydroxy-4-(3′,4′-dichlorophenyl) hexanamide and DL-4-hydroxy-4-(4′-bromophenyl)hexanamide. They have a significant anticonvulsant activity against pentylenetetrazol-induced seizures as well as unexpected differences in anticonvulsant activity respect those of the non-halogenated compounds. The invention further provides methods for the synthesis of the DL-hydroxy-alkyl-phenyl amides as exemplified in the examples.

专利号:US-10814013-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications

专利号:US-2008107598-A1
优先权日:2006-10-05
标 题:Efficient Synthesis of Chelators for Nuclear Imaging and Radiotherapy: Compositions and Applications

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主要参考文献

参考标题:(Tosylimino)Phenyl-λ3-Iodane As A Reagent For The Synthesis Of Methyl Carbamates Via Hofmann Rearrangement Of Aromatic And Aliphatic Carboxamides
作者:Akira Yoshimura,Matthew W. Luedtke,Viktor V. Zhdankin |发布日期:2012.2.17
摘要:A New, Mild Procedure For The Hofmann Rearrangement Of Aromatic And Aliphatic Carboxamides Using (Tosylimino)Phenyl-λ3-Iodane, Phints, As A Reagent Is Reported. Because Of The Mild Reaction Conditions, This Method Is Particularly Useful For The Hofmann Rearrangement Of Substituted Benzamides, Which Usually Afford Complex Reaction Mixtures With Other Hypervalent Iodine Oxidants. The Mild Reaction Conditions

合成参考文献


摘要:Hall, M.; Faber, K.; Tasnádi, G., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 315.
摘要:National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review., 5(9), 1953
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