CAS: 824-55-5; 2,4-Dimethylbenzyl Chloride

该化合物是一种多用途芳香化合物,在2,4个位置的1个位置和2,4个位置的甲基组别上,有不同的氯甲基替代,具有高度稳定性和极佳的回动性,适合广泛的化学变异.其结构特征有利于高效替代反应,而氯甲基组别则增强了其在有机合成中的回动性.该化合物对于药物,农用化学品和精细化学品的应用是理想的.

英文名称2,4-Dimethylbenzyl Chloride
中文名称1-(氯甲基)-2,4-二甲苯
IUPAC名称1-(chloromethyl)-2,4-dimethylbenzene
其它别名1,3-Dimethyl-4-chloromethylbenzene; 1-(Chloromethyl)-2,4-dimethylbenzene; 2,4-Dimethylbenzyl chloride; 4-(Chloromethyl)-m-xylene
CAS编号824-55-5
MFCD编号:MFCD00015556
EINECS号:212-531-7
分子式:C9H11Cl
分子量:154.64
产品CID: 1815308
产品分类化学试剂 → 有机试剂 → 酰卤

相似结构搜索
产品信息参考
InChIKey: BETNPSBTDMBHCZ-UHFFFAOYSA-N
InChI=1S/C9H11Cl/c1-7-3-4-9(6-10)8(2)5-7/h3-5H,6H2,1-2H3…
计算化学: 氢键受体数*氢键供体数0.0可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS02 & GHS07;
注释: Flame & Exclamation mark
危险类别易燃液体类别3
急性毒性类别4(吸入)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2
皮肤腐蚀类别1B
急性毒性类别4(经口)
金属腐蚀物类别1
严重眼损伤类别1
警示词Warning(警告)
危险描述H226 |易燃液体和蒸气.
H332 |吸入有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H314 |造成严重皮肤灼伤和眼损伤.
H302 |吞咽有害.
H290 |可能对金属造成腐蚀.
H318 |造成严重眼损伤.
防范说明P280-P305+P351+P338-P309-P310
危险等级8
UN编号3265
危险品标志C,Xi
包装等级II
安全声明45-36/37/39-25
危险类别码34

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

16308-92-2 = 824-55-5
反应条件:1.1 Reagents: Thionyl Chloride Solvents: Benzene
标题:Aromatic Spiranes. Xx. Syntheses Of Dimethylsubstituted 2-Carboxymethyl-Indan-1-Ones And Benzylchlorides As Synthones For Synthesis Of Di- To Tetramethylsubstituted Spirobiindandiones
作者:Neudeck,H. K.
参考文献:Monatshefte Fuer Chemie 日期:1996 卷标:127(2) 页码:185-200]

16308-92-2 = 824-55-5
反应条件:1.1 Reagents: Oxalyl Chloride,Tropone Solvents: Dichloromethane; Rt; 5 Min,Rt1.2 Solvents: Dichloromethane; Rt; 25 Min,Rt
标题:Aromatic Cation Activation: Nucleophilic Substitution Of Alcohols And Carboxylic Acids
作者:Nguyen,Thanh V.; Et Al
参考文献:Organic Letters 日期:2014 卷标:16(6) 页码:1720-1723]

= 824-55-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Acetic Acid,Zinc Chloride,Sulfuric Acid,Polyethylene Glycol Solvents: Toluene; 8 H,40 °C
标题:An Inexpensive And Convenient Procedure For Chloromethylation Of Aromatic Hydrocarbons By Phase Transfer Catalysis In Aqueous Media
作者:Hu,Yu Lin; Et Al
参考文献:Journal Of The Chilean Chemical Society 日期:2010 卷标:55(1) 页码:97-102]

= 824-55-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: 1-Propanaminium,N,N,N-Triethyl-3-Sulfo-,Inner Salt Solvents: Water; 2 H,60 °C
标题:Chloromethylation Of Alkylbenes Catalyzed By Sulfonic Ammonium
作者:Shang,Jie; Et Al
参考文献:Fenzi Cuihua 日期:2010 卷标:24(4) 页码:333-338]

15764-16-6 = 824-55-5
反应条件:1.1 Reagents: Sodium Borohydride Solvents: Methanol; 0 °C; 0 °C -> Rt; Overnight,Rt2.1 Reagents: Thionyl Chloride Solvents: Dichloromethane; 0 °C; 0 °C -> Rt; Overnight,Rt
标题:One-Pot Synthesis Of Multisubstituted Propenylbenzenes From Benzyl Chlorides Through Relay Catalysis Of Palladium
作者:Wang,Haiyu; Et Al
参考文献:Organic & Biomolecular Chemistry 日期:2023 卷标:21(29) 页码:6034-6038]

= 824-55-5 + 1585-15-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: 1-Ethyl-3-Methylimidazolium Hexafluorophosphate Solvents: Water; 5 H,70 °C
标题:An Experimental And Theoretical Study On Imidazolium-Based Ionic Liquid Promoted Chloromethylation Of Aromatic Hydrocarbons
作者:Wang,Yun; Et Al
参考文献:Journal Of The Chilean Chemical Society 日期:2013 卷标:58(4) 页码:2196-2199]

= 824-55-5 + 1585-15-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Hexadecyltrimethylammonium Bromide Solvents: Water; 2 H1.2 Reagents: Hydrochloric Acid; 4 H,80 °C; Cooled1.3 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
标题:Chloromethylation Of Aromatic Compounds Catalyzed By Surfactant Micelles In Oil-Water Biphasic System
作者:Liu,Qifa; Et Al
参考文献:Catalysis Letters 日期:2009 卷标:131(3-4) 页码:485-493]

= 824-55-5 + 123413-30-9 + 2735-07-1 + 148990-23-2
反应条件:1.1 Reagents: Iodogen Catalysts: Azobisisobutyronitrile Solvents: Carbon Tetrachloride; 2 H,81 °C
标题:Improved Halogenation Of Methyl Aromatics And Methyl Heteroaromatics: Unexpected Reactivity Of Tetrahalogeno-Diphenylglycolurils
作者:Moretti,Florian; Et Al
参考文献:Heteroatom Chemistry 日期:2016 卷标:27(3) 页码:173-183]

= 824-55-5 + 41381-35-5 + 102-46-5 + 824-45-3 + 31053-96-0 + 1746-26-5
反应条件:1.1 Reagents: Chlorine Dioxide Solvents: Water; 1.75 H,Rt1.2 Reagents: Sodium Thiosulfate
标题:Chlorination And Oxidation Products Formed From 1,2,4-Trimethylbenzene In Aqueous Solution Under The Action Of Chlorine Dioxide
作者:Khasanova,Z. R.; Et Al
参考文献:Russian Journal Of Applied Chemistry 日期:2007 卷标:80(7) 页码:1105-1110]

= 824-55-5 + 102-46-5 + 824-45-3
反应条件:1.1 Reagents: Carbon Tetrachloride Catalysts: Acetonitrile,Molybdenum Hexacarbonyl; 1 H,170 °C
标题:Synthesis Of Benzyl Chlorides And Diarylmethanes Via Coupled Reactions Of Methylarenes With Carbon Tetrachloride In The Presence Of Manganese- And Molybdenum-Containing Catalysts
作者:Khusnutdinov,R. I.; Et Al
参考文献:Neftekhimiya 日期:2004 卷标:44(4) 页码:293-300]

16308-92-2 = 824-55-5
反应条件:1.1 Reagents: Thionyl Chloride Catalysts: Dimethylformamide Solvents: Dichloromethane; 0 °C; 14 H,0 °C1.2 Reagents: Sodium Bicarbonate Solvents: Water
标题:Ir-Catalyzed Asymmetric And Regioselective Hydrogenation Of Cyclic Allylsilanes And Generation Of Quaternary Stereocenters Via The Hosomi-Sakurai Allylation
作者:Rabten,Wangchuk; Et Al
参考文献:Chemistry - A European Journal 日期:2018 卷标:24(7) 页码:1681-1685]

= 824-55-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Poly(Oxy-1,2-Ethanediyl),α-[2-(1-Methyl-1H-Imidazolium-3-Yl)Ethyl]-ω-[2-(1-Meth... Solvents: Methylcyclohexane,Water; Rt; 8 H,75 °C
标题:An Efficient Procedure For Chloromethylation Of Aromatic Hydrocarbons Catalyzed By Peg1000-Dicationic Ionic Liquids In Aqueous Media
作者:Hu,Yu Lin; Et Al
参考文献:Chemcatchem 日期:2010 卷标:2(4) 页码:392-396]

7093-91-6 = 824-55-5
反应条件:1.1 Reagents: Iron Chloride (Fecl3)
标题:Arylmethyl Isocyanates
作者:Kozhushko,B. N.; Et Al
参考文献:Zhurnal Organicheskoi Khimii 日期:1984 卷标:20(4) 页码:721-7]

= 824-55-5 [标题:Reaction Conditions
标题:Aromatic Ketoethers. Condensation Products Of 4,4'-Dihydroxybenzophenone With Methylchloride Compounds
作者:Iovu,Mircea; Et Al
参考文献:Revistade Chimie (Bucharest 日期:1981 卷标:32(6) 页码:548-55]

= 824-55-5 + 1585-15-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Scandium Triflate Solvents: Water; 5 H,70 °C
标题:Rare Earth Metal Triflates As Versatile Catalysts For The Chloromethylation Of Aromatic Hydrocarbons
作者:Kishida,Toru; Et Al
参考文献:Green Chemistry 日期:2004 卷标:6(1) 页码:57-62]

= 824-55-5 + 1585-15-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Scandium Triflate Solvents: Water; 5 H,70 °C
标题:Rare-Earth Metal Triflates. An Environment Conscious Catalyst For The Chloromethylation Of Aromatic Hydrocarbons
作者:Kishida,Toru; Et Al
参考文献:Transactions Of The Materials Research Society Of Japan 日期:2004 卷标:29(5) 页码:2203-2206]

= 824-55-5 + 5402-60-8
反应条件:1.1 Reagents: Zinc Chloride,Hydrochloric Acid Solvents: Water; 3.5 H,Rt
标题:Synthesis And Molecular Structures Of Zirconium And Hafnium Complexes Bearing Dimethylsilandiyl-Bis-2,4,6-Trimethylindenyl And Dimethylsilandiyl-Bis-2-Methyl-4,6-Diisopropylindenyl Ligands
作者:Izmer,Vyacheslav V.; Et Al
参考文献:Journal Of Organometallic Chemistry 日期:2005 卷标:690(4) 页码:1067-1079]

= 824-55-5 + 1585-15-5
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Zinc Chloride Solvents: Water; 5 H,70 °C
标题:Strong Organic Acids As Efficient Catalysts For The Chloromethylation Of M-Xylene: The Synthesis Of 1,3-Bis(Chloromethyl)-4,6-Dimethylbenzene
作者:Kishida,Tohru; Et Al
参考文献:Industrial & Engineering Chemistry Research 日期:2009 卷标:48(4) 页码:1831-1839

2,4-二甲基溴苯置于lithium Aluminium Tetrahydride,氯化亚砜,Magnesium体系中,用乙醚,苯作为反应溶剂,化学反应 25.0H,反应生成 1-(氯甲基)-2,4-二甲苯
参考文献:Aromatische Spirane,20. Mitt.: Darstellung Von Dimethylsubstituierten 2-Carboxymethyl-Indan-1-Onen Und Benzylchloriden Als Synthone Fr Synthesen Von Di-Bis Tetramethylierten 2,2-Spirobiindandionen
标题:Aromatische Spirane,20. Mitt.: Darstellung Von Dimethylsubstituierten 2-Carboxymethyl-Indan-1-Onen Und Benzylchloriden Als Synthone Fr Synthesen Von Di-Bis Tetramethylierten 2,2-Spirobiindandionen
摘要:The Isomeric Dimethyl Methylbenzoates 5,Obtained From The Bromides Via Grignard Reactions With Dimethylcarbonate,Were Reduced With Lialh4 To The Hydroxymethyl Derivatives 6. The Latter Were Then Transformed Both To The Benzylchlorides 7 (With Socl2) And To The Aldehydes 8 (With Pyridinium Chlorochromate). Knoevenagel-Doebner Reaction Of 8 Afforded The Acrylic Acids 9 Which (After Hydrogenation To 11) Were Cyclized To The Desired Indanones 12 With Polyphosphoric Acid. On The Other Hand,12C And 12E Were Prepared From Dimethyl 3-Chloropropiophenone (14) By Warming With Sulfuric Acid. After Nah-Catalyzed Reaction With Dimethylcarbonate,The Indanones 12 Gave The Ketoesters 15 Which Then Could Be Hydrogenated To The Indanes 16. All Reactions Proceeded With Satisfactory To Excellent Yields (60-90%).
DOI:10.1007/bf00807400

海关参考信息

2902300000-甲苯
2903110000-一氯甲烷及氯乙烷
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-4536599-A
优先权日:1978-08-22
标题:Synthesis of amine derivatives
发明人：MASUKO FUJIO; KATSURA TADASHI
权利人:SUMITOMO CHEMICAL CO
摘要:An amine of the formula, ##STR1## wherein R 1 , R 2 , R 3 , R 4 and R 5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including Î±-phenyl-Î²-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.

专利号:EP-0008532-A1
优先权日:1978-08-22
标题 :Synthesis of amines

专利号:EP-0008532-B1
优先权日:1978-08-22
标题 :Synthesis of amines

专利号:EP-0040896-A2
优先权日:1978-08-22
标题 :Synthesis of amides

专利号:RU-2140417-C1
优先权日:1995-10-17
标题:Derivatives of hydrogenated pyrido[4,3-b]indoles, methods of their synthesis, pharmaceutical composition and method of patient treatment