CAS: 81-93-6; Phenosafranine

该化合物是一种基于苯丙胺的染料,通常用作分析和组织学应用中的红氧化指标和生物污点.其化学结构,C18H15ClN4, 具有核酸的强烈亲近性,使其在电光和显微镜中对DNA和RNA可视化具有价值.该化合物显示出可逆的红氧化行为,使其在电化学研究和电子转移调解中得以使用.Phenosafraine还因其光活性特性,被用于光动力治疗研究中.其在水溶液和不同色度反应中的稳定性加强了定量分析的可复制性.某些细胞成分的染色选择进一步证明了其在细胞染色协议中的实用性.

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合成工艺路线路线简述

    📜Pseudo-Mauveine置于lead Dioxide体系中,化学反应生成 酚藏花红
    参考文献:1-(Phenylamino)Pseudo-Mauveine: A New Water Soluble Phenazine Dye
    标题:1-(Phenylamino)Pseudo-Mauveine: A New Water Soluble Phenazine Dye
    摘要:1-(Phenylamino)Pseudo-Mauveine Was Prepared By The Oxidation Of 1,3,5-Tris(Phenylamino)Benzene And P-Phenylenediamine With Potassium Dichromate. The Absorption Maximum Of 535 Nm Is Shifted Hypsochromically By About 20 Nm Compared To That For Pseudo-Mauveine. Condensation Of 1,3,5-Tris(Phenylamino) Benzene With 4-Nitrosodiphenylamine Under Strongly Acidic Conditions Gave 1,3,7-Tris(Phenylamino)-5-Phenylphenazinium Sulfate And 10-Phenyl-6,8-Bis(Phenylamino)-2,10-Dihydrophenazin-2-One.
    DOI:10.3184/174751914X14033559668812

    专利信息


    专利号:US-4300013-A
    优先权日:1976-11-05
    标 题 :Isomerization of xylenes
    发明人:WHITTAM THOMAS V
    权利人:ICI LTD
    摘要:A silica-containing material related to zeolites and referred to hereinafter as FU-1 has the composition 0.6 to 1.4 R 2 O.Al 2 O 3 .over 5 SiO 2 .O to 40 H 2 O, (where R is a monovalent cation or 1/n of a cation of valency n) and is characterized inter alia by its X-ray diffraction pattern. It can be made by hydrothermal synthesis in presence of methylated quaternary onium compounds. It is useful as a catalyst for hydrocarbon conversion reactions, especially isomerization of xylenes.

    专利号:EP-4206236-A1
    优先权日:2021-12-28
    标题 :Compounds, their synthesis and compositions comprising the compounds for enhanced deposition of polymers onto hair surfaces
    发明人:BREAKSPEAR STEVEN; NÖCKER BERND; WEITZEL JOHANNA; PAEZ JULIETA; PEARSON SAMUEL; BRÜCK STEFAN; CAMPO ARANZAZU DEL
    权利人:KAO CORP
    摘要:The present invention is on polymers derivatized with an organic deposition-enhancing group for their enhanced deposition onto keratin fibers, especially human hair. The deposition-enhancing group is a di-hydroxyl phenolic compound with a spacer alkyl group bound to a reactive amine or carboxyl group, which reacts with one of the hydroxyl, carboxyl, primary and secondary amine groups on the polymeric backbone. The invention is on the method of synthesizing such compounds and compositions comprising the compounds.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Liu, W., Et Al. Characterization Of Phenosafranine–hemoglobin Interactions In Aqueous Solution. J Solution Chem 40, 231–246 (2011).
    [参考文献]: Pradhan Ab, Et Al. An Overview On The Interaction Of Phenazinium Dye Phenosafranine To Rna Triple And Double Helices. Int J Biol Macromol. 2016 May;86:345-51.
    [参考文献]: Widholm Jm. The Use Of Fluorescein Diacetate And Phenosafranine For Determining Viability Of Cultured Plant Cells. Stain Technol. 1972 Jul;47(4):189-94.
    [参考文献]: A Mitra, Et Al. Spectrophotometric And Spectrofluorometric Studies On Interaction Of Cationic Dyes With Bacterial Capsular Polysaccharide. Indian J Biochem Biophys. 1998 Aug;35(4):241-6.
    [参考文献]: Asok K Jana, Et Al. Studies On The Molecular Interaction Of Phenazine Dyes With Triton X-100. Spectrochim Acta A Mol Biomol Spectrosc. 2004 Jul;60(8-9):2093-7.

    合成参考文献


    摘要:National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program., JAN1986
    摘要:U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals., NX#05194
    参考文献:10.2116/analsci.22.691
    摘要:Sun W, You J, Hu X, Jiao K. Microdetermination of double-stranded DNA by linear sweep voltammetry with phenosafranine. Anal Sci. 2006 May;22(5):691–6. doi: 10.2116/analsci.22.691.
    参考文献:10.1007/s10529-008-9700-y
    摘要:Borole AP, O'Neill H, Tsouris C, Cesar S. A microbial fuel cell operating at low pH using the acidophile Acidiphilium cryptum. Biotechnol Lett. 2008 Aug;30(8):1367–72. doi: 10.1007/s10529-008-9700-y.
    参考文献:10.1186/1752-153x-6-161
    摘要:Zucca P, Rescigno A, Pintus M, Rinaldi AC, Sanjust E. Degradation of textile dyes using immobilized lignin peroxidase-like metalloporphines under mild experimental conditions. Chemistry Central Journal. 2012 Dec;6(1). doi: 10.1186/1752-153x-6-161.
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