CAS: 7787-68-0; Bismuth Sulfate

专利信息

专利号:US-12304885-B2
优先权日:2022-04-20
标 题:Synthesis and purification of CBDA
发明人：SHEARER RANDALL L
权利人:UNIV COLORADO REGENTS; UNIV COLORADO REGENTS
摘要:Methods and systems for the preparation of high purity and high quality cannabinoid acids and metal salts of cannabinoids. Cannabidiolic acid (CBDA) is a major cannabinoid of interest for and health reasons. It is the natural precursor of cannabidiol (CBD). The invention provides methods for the synthesis of CBDA from CBD with reagents that produce a high purity product without need for further purification. Insertion of a magnesium complexing agent prior to conversion of the reaction intermediate to the final acid product produces a high purity product with aesthetically pleasing white color and neutral odor. Methods are provided for the simultaneous synthesis and purification of cannabinoid acids, especially CBDA, produced from high purity CBD (or other cannabinoid) via a Kolbe-Schmitt type reaction using an organic base, such as DBU (1,8-diazabicyclo[5.4.0]undec-7-ene), incorporating complexation of acid anions to a multivalent metal, alkaline earth or transition metal, prior to product acid work-up. During the work-up to the final acid, the distinct solubility of the complex in selected solvents is used advantageously to first exclude water soluble reagents and impurities and next to exclude lipophilic hydroxyl-quinone impurities, as well as any unconverted CBD.

专利号:EP-1871745-B1
优先权日:2005-04-15
标 题:Preparation of 2-substituted 4-chloro-5-formylimidazoles by vilsmeier reaction of the condensation product of glycine and an imido ester with a formamide in the presence of a triflate (trifluormethanesulphonate) catalyst
发明人：RAJNIKANT VYAS JANMEJAY; SATYA VARMA NIDADAVOLU VENKATA; PRAKASH SINGH ANAND
权利人:DISHMAN PHARMACEUTICALS AND CH
摘要:The invention relates to a preparation process for 2-substituted 5-formylimidazoles, wherein the intermediate high-pressurized synthesis of an 2-substituted 4-hydroxymethylimidazole as known in the art is conveniently avoided, and wherein much higher yields are obtained. Instead, it is proposed to prepare such 2-substituted 5-formylimidazoles via a one-pot synthesis involving 2-substituted 4-chloro-5-formylimidazole, thereby employing an additional hydrodehalogenation step. Moreover, it is found that the yield and purity of 2-substituted 4-chloro-5-formylimidazole itself can be significantly improved using a triflate catalyst in the preparation process.

专利号:US-8957260-B2
优先权日:2011-02-07
标题 :Process for the oxidation of mesitol
发明人：WEYRAUCH JAN PHILIPP; WEIS MARTINE; TELES JOAQUIM HENRIQUE; EBEL KLAUS; DEGLMANN PETER
权利人:WEIS MARTINE; TELES JOAQUIM HENRIQUE; EBEL KLAUS; DEGLMANN PETER; WEYRAUCH VIVIEN ELLINOR; WEYRAUCH GUNHILD; BASF SE
摘要:The invention relates to a process for the oxidation of mesitol with singlet oxygen, which is released from hydrogen peroxide, this release taking place in the presence of a bismuth compound as catalyst. In the process, 2,4,6-trimethylquinol is formed in high yield and selectivity as product, which can be used in further reactions for the synthesis of vitamins and in particular of vitamin A and vitamin E.

专利号:RU-2186055-C2
优先权日:1995-05-24
标 题 :Method of synthesis of derivatives 3-carboxy-4-hydroxybenzaldehyde, method of synthesis of 4-hydroxybenzaldehyde, methods of synthesis of vanillin and ethylvanillin

专利号:WO-2025118316-A1
优先权日:2023-12-08
标 题 :In-situ preparation method for composite pigment of bismuth vanadate
发明人：YIN XIANGLU; CENG ZEHUA; ZHANG DONGBIN; DAI YU; TENG AIJUN
权利人:ANSTEEL BEIJING RES INSTITUTE CO LTD
摘要:An in-situ preparation method for a composite pigment of bismuth vanadate, which method comprises: firstly dissolving a bismuth compound into an acidic solution, adding a surfactant thereto for full dissolution, and then adding titanium-nickel yellow particles to the solution; adding a vanadium compound to the mixed solution under the action of a strong shearing force; and reacting same at a certain temperature and pH value, then cleaning and drying the precipitate separated from the mixed solution, and subjecting same to a heat treatment to obtain a composite pigment powder of bismuth vanadate. A synthesis reaction of bismuth vanadate is uniformly performed on the surface of titanium-nickel yellow in situ under the action of a strong shearing force. By means of the method, not only is the in-situ composite reaction performed more quickly and uniformly, but a large amount of alkaline solution required by a conventional method is also avoided. The obtained composite pigment of bismuth vanadate has a high chromatic value, and a more effective covering power and dilution strength.

专利号:US-2011104052-A1
优先权日:2007-12-03
标 题 :Methods of synthesis and use of chemospheres
发明人：BARNETT BRADLEY POWERS; GESCHWIND JEFFREY
权利人:UNIV JOHNS HOPKINS
摘要:The present invention provides, in general, compositions comprising a hydrogel and an agent, for example a therapeutic agent or an imaging agent, for locoregional delivery. In certain preferred embodiments of the invention, the hydrogel compositions are detectable by Magnetic Responance and CT Scan and are used for locoregional delivery of therapeutic agents, for example chemotherapeutic agents. The invention also features polymer matrix compositions comprising nanoparticles that can be loaded after polymerization with bioactive agents, for example a diagnostic agent or therapeutic agent.