CAS: 6967-82-4; 2-Bromo-5-Methylbenzoic Acid

该化合物是一种含有分子式C8H7BRO2的溴化芳烃酸,该化合物的特点是2位置的溴替代物和5位置相对于箱式酸功能的甲基组,使其成为有机合成的多种中间体,其结构特性使得药物,农用化学品和材料科学的应用成为可能,特别是在诸如Suzuki-Miyaura或Buchwald-Hartwig等交叉反应中,例如Suzuki-Miyaura或Buchwald-Hartwig交织物中.电镀(溴)和电镀(甲基)组的存在为选择性功能化提供了金枪鱼再活动.高纯度能确保研究和工业过程的一贯性能.由于潜在的刺激性,建议适当处理.

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欧盟法规

ECHA物质C&L通报

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CAS号42872-83-3 2-溴-5-甲基苯腈 | CAS号99-04-7 间甲基苯甲酸 | CAS号2941-78-8 2-氨基-5-甲基苯甲酸 | CAS号37460-74-5 4-bromo-m-cumene | CAS号7697-37-2 硝酸 | CAS号7726-95-6 溴素 | CAS号90221-55-9 2-溴-5-甲基苯甲醛 | CAS号27561-50-8 1-溴-2-(溴甲基)-4-甲基苯 | CAS号89-56-5 5-甲基水杨酸 | CAS号1088994-18-6 5-甲基-2-(4,4,5,5... | CAS号727985-37-7 (2-溴-5-甲基苯基)甲醇 | CAS号90971-88-3 2-溴-5-甲基苯甲酸甲酯 | CAS号378242-13-8 2-(3-carboxyphe...

合成工艺路线路线简述

    2-氨基-5-甲基苯甲酸 反应生成 2-溴-5-甲基苯甲酸
    参考文献:Ultraviolet Spectra Of Substituted Acetophenones And Benzoic Acids
    标题:Ultraviolet Spectra Of Substituted Acetophenones And Benzoic Acids
    摘要:
    DOI:10.1021/jo01076A039

    海关参考信息

    专利信息


    专利号:US-7943723-B2
    优先权日:2006-12-21
    标 题:Process for the synthesis of ethers of aromatic acids
    发明人:RITTER JOACHIM C
    权利人:DU PONT
    摘要:The inventions disclosed herein include processes for the preparation of an ether of an aromatic acid, processes for the preparation of products into which such an ether can be converted, the use of such processes, and the products obtained and obtainable by such processes. A key feature of the processes described is the use of a solvent comprising an alcohol ROH and an alcoholate RO − M + .

    专利号:US-8106031-B2
    优先权日:2006-05-02
    标题:Hydrolytically-resistant boron-containing therapeutics and methods of use
    发明人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
    权利人:LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A; ANACOR PHARMACEUTICALS INC
    摘要:Compositions and methods of use of boron derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by fungi, yeast, bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

    专利号:US-8207374-B2
    优先权日:2006-12-21
    标 题:Process for the synthesis of ethers of aromatic acids
    发明人:RITTER JOACHIM C
    权利人:RITTER JOACHIM C; DU PONT
    摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.

    专利号:US-2011060118-A1
    优先权日:2009-09-02
    标 题:Process for the synthesis of fluorinated ethers of aromatic acids
    发明人:RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; MAHAJAN DU SURBHI
    权利人:DU PONT
    摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a Schiff base ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.

    专利号:US-7985825-B2
    优先权日:2006-12-21
    标 题 :Process for the synthesis of ethers of aromatic acids
    发明人:RITTER JOACHIM C
    权利人:DU PONT
    摘要:Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a halogenated aromatic acid such as is described by the structure of Formula II n nwherein each X is independently Cl, Br or I; the reaction mixture further comprising;n (i) a polar protic solvent, a polar aprotic solvent or an alcoholic solvent containing the alcoholate RO-M+ (wherein M is Na or K), wherein the polar protic solvent, polar aprotic solvent or alcoholic solvent is either ROH or is a solvent that is less acidic than ROH; (ii) a copper (I) or copper (II) source; and (iii) an amino acid ligand that coordinates to copper, wherein the ligand comprises an amino acid in which the amine nitrogen and the carboxyl carbon are separated by no more than two carbon atoms.

    专利号:US-2011060117-A1
    优先权日:2009-09-02
    标题:Process for the synthesis of fluorinated ethers of aromatic acids
    发明人:RITTER JOACHIM C; MOLOY KENNETH GENE; POLLINO JOEL M; MAHAJAN DU SURBHI
    权利人:DU PONT
    摘要:Fluorinated ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diamine ligand that coordinates to copper. The fluorinated ethers of aromatic acids made using the process described herein can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.
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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Sanford, M. S.; Cook, A., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 2, 204.
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