CAS: 64-31-3; Morphine Sulfate

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CAS号466-99-9 氢吗啡酮 | CAS号57-27-2 吗啡 | CAS号125-29-1 氢可酮 | CAS号519-98-2 4-(甲氨基)安替比林

📜吗啡置于硫酸体系中,用 醋酸异丙酯,水 作为反应溶剂,化学反应生成 吗啡硫酸盐甲醇
参考文献:Crystalline Forms Of Morphine Sulfate
标题:Crystalline Forms Of Morphine Sulfate
摘要:本公开涉及吗啡硫酸盐的结晶形式和包含任何这些结晶形式的药物组合物.还提供了制备吗啡硫酸盐结晶形式的方法.

专利信息

专利号:WO-2012088402-A1
优先权日:2010-12-22
标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain
发明人：BOHN LAURA M; MICALIZIO GLENN C
权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C
摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.

专利号:US-8481501-B2
优先权日:2004-05-28
标 题 :Synthesis of metabolically stable analgesics, pain medications and other agents
发明人：CASHMAN JOHN R; MACDOUGALL JAMES M
权利人:CASHMAN JOHN R; MACDOUGALL JAMES M; HUMAN BIOMOLECULAR RES INST
摘要:Disclosed are analgesic-related compositions and methods of using the compositions for modulation of analgesic receptor activity. The compositions and methods are useful for reducing pain, as well as for therapeutic intervention of addictions or other diseases or disorders amenable to treatment or prophylaxis by modulation of analgesic receptor signaling.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.

专利号:US-8569265-B2
优先权日:2011-05-06
标题:Deuterated analogs of (4S)-4-ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3′, 4′:6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof
发明人：CHEN XINGHAI; HUANG QIULI; KOCHAT HARRY; MALAKHOV ANDREY; HAUSHEER FREDERICK H
权利人:CHEN XINGHAI; HUANG QIULI; KOCHAT HARRY; MALAKHOV ANDREY; HAUSHEER FREDERICK H; BIONUMERIK PHARMACEUTICALS INC
摘要:The present invention discloses: (i) two novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (ii) methods of synthesis of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, and/or derivatives thereof; (iii) pharmaceutically-acceptable formulations comprising said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents; and (iv) methods of administration of said novel deuterated Karenitecin® analogs, pharmaceutically-acceptable salts, derivatives thereof; and/or, optionally, one or more additional chemotherapeutic agents, to subjects in need thereof.

专利号:US-4238390-A
优先权日:1979-05-09
标题 :Synthesis and biological activity of [D-Thr2, Δ3 Pro5 ]-enkephalinamide
发明人：MEIENHOFER JOHANNES A
权利人:HOFFMANN LA ROCHE
摘要:The present disclosure is directed to the synthesis and biological activity of [D-Thr 2 , Δ 3 Pro 5 ]-enkephalinamide. The subject compound is useful as an agent for the inhibition of diarrhea and also exhibits analgesic activity.

专利号:US-2023331690-A1
优先权日:2020-11-01
标 题 :Thc derivatives, oral dosage forms comprising same, uses thereof for treating diseases and disorders and synthesis thereof
发明人：ALBECK AMNON; WOLFMAN JACOB; EYAL NADAV
权利人:UNIV BAR ILAN; EYBNA TECH LTD
摘要:Provided herein are THC derivatives, formulations thereof, synthesis thereof and uses thereof through oral administration, for treatment of diseases and disorders.