专利号:US-2002077491-A1 优先权日:2000-09-05 标 题 :Methods for forming combinatorial libraries combining amide bond formation with epoxide opening 发明人:SHIPPS GERALD W; ROSNER KRISTIN E; MAKARA GERGELY M; WINTNER EDWARD A; NASH HUW M; FELSCH JASON S; PAL KOLLOL; LENZ GEORGE R 摘要:The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide bond formation with epoxide opening.
专利号:US-2002115106-A1 优先权日:2000-12-22 标题 :Methods for forming combinatorial libraries using reductive amination 发明人:SHIPPS GERALD W; PAL KOLLOL 权利人:NEOGENESIS PHARMACEUTICALS INC 摘要:The invention relates to methods for forming combinatorial libraries. The invention provides methods suitable for the rapid and convenient synthesis of very large combinatorial libraries of small organic molecules. In particular, the invention provides a method for forming combinatorial libraries combining amide, sulfonamide, or urea bond formation with reductive amination.