CAS: 53531-01-4; Ethyl 4-[(2,3,4-Trimethoxyphenyl)Methyl]Piperazine-1-Carboxylate

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CAS号120-43-4 N-哌嗪甲酸乙酯 | CAS号2103-57-3 2,3,4-三甲氧基苯甲醛 | CAS号5011-34-7 曲美他嗪

📜N-哌嗪甲酸乙酯,2,3,4-三甲氧基苯甲醛置于sodium Cyanoborohydride,溶剂黄146体系中,化学反应 16.0H,反应生成 4-[(2,3,4-三甲氧基苯基)甲基]-1-哌嗪羧酸乙酯
参考文献:Flavonoid-Related Modulators Of Multidrug Resistance: Synthesis,Pharmacological Activity,And Structure−activity Relationships
标题:Flavonoid-Related Modulators Of Multidrug Resistance: Synthesis,Pharmacological Activity,And Structure−activity Relationships
摘要:A Series Of 28 Flavonoid Derivatives Containing A N-Benzylpiperazine Chain Have Been Synthesized And Tested For Their Ability To Modulate Multidrug Resistance (Mdr) In Vitro. At 5 Mu M,Most Compounds Potentiated Doxorubicin Cytotoxicity On Resistant K562/dox Cells. They Were Also Able To Increase The Intracellular Accumulation Of Jc-1,A Fluorescent Molecule Recently Described As A Probe Of P-Glycoprotein-Mediated Mdr. This Suggests That These Compounds Act,At Least In Part,By Inhibiting P-Glycoprotein Activity. As In Other Studies,Lipophilicity Was Shown To Influence Mdr-Modulating Activity But Was Not The Only Determinant. Diverse Di-And Trimethoxy Substitutions On N-Benzyl Were Examined And Found To Affect The Activity Differently. The Most Active Compounds Had A 2,3,4-Trimethoxybenzylpiperazine Chain Attached To Either A Flavone Or A Flavanone Moiety (13,19,33,And 37) And Were Found To Be More Potent; Than Verapamil.
DOI:10.1021/jm981064B