📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氢氧化钾体系中,化学反应生成 花青 参考文献:Hoogewerff; Van Dorp,Recueil Des Travaux Chimiques Des Pays-Bas,1884,Vol. 3,P. 345 标题:Hoogewerff; Van Dorp,Recueil Des Travaux Chimiques Des Pays-Bas,1884,Vol. 3,P. 345
专利号:US-7241399-B2 优先权日:2000-09-08 标题 :Synthesis of nanoparticles 发明人:HAUBOLD STEPHAN; HAASE MARKUS; RIWOTZKI KARSTEN; WELLER HORST; MEYSSAMY HEIKE; IBARRA FERNANDO 权利人:CT ANGEWANDTE NANOTECH CAN 摘要:Methods for the preparation of inorganic nanoparticles capable of fluorescence, wherein the nanoparticles consist of a host material that comprises at least one dopant. The synthesis of the invention in organic solvents allows to gain a considerably higher yield compared to the prior art synthesis in water. All kinds of objects can advantageously be marked and reliably authenticated by using an automated method on the basis of a characteristic emission. Further, the size distribution of the prepared nanoparticles is nartower which renders a subsequent size-selected separation process superfluous.
专利号:US-10870649-B2 优先权日:2017-04-13 标题:Synthesis of NIR fluorescent probe 发明人:LATTUADA LUCIANO; BUONSANTI FEDERICA; CRIVELLIN FEDERICO; FERRETTI FULVIO; MAISANO FEDERICO; ORIO LAURA; PIZZUTO LORENA 权利人:BRACCO IMAGING SPA 摘要:The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.
专利号:US-10973847-B2 优先权日:2017-06-30 标题 :Core-to-surface polymerization for the synthesis of star polymers and uses thereof 发明人:JOHNSON JEREMIAH A; GOLDER MATTHEW R 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:Disclosed are methods, compositions, reagents, systems, and kits to prepare star polymers, as well as compositions and uses thereof. Various embodiments show that synthesis of these polymers contain low metal concentration to provide polymers for diverse biomedical applications including in vivo applications.
专利号:US-9365607-B1 优先权日:2012-07-31 标题 :Synthesis of deuterated ribo nucleosides, N-protected phosphoramidites, and oligonucleotides 发明人:SRIVASTAVA SURESH C; YASKO AMY 权利人:ASED LLC 摘要:The present invention is directed towards the synthesis of high purity deuterated sugars, deuterated phosphoramidites, deuterated nucleobases, deuterated nucleosides, deuterated oligonucleotides, and deuterated RNA's of defined sequences which can exhibit biochemically useful and biologically valuable properties, thus having potential for therapeutic uses.
专利号:US-7691635-B2 优先权日:2004-03-26 标题 :Labeling reagents, methods for the synthesis of such reagents and methods for the detection of biological molecules 发明人:LAAYOUN ALI; BERNAL-MENDEZ ELOY 权利人:BIOMERIEUX SA 摘要:The present invention relates to a temperature-stable labeling reagent of formula (0): n nin which:n R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable marker or at least two detectable markers interlinked by at least one multimeric structure, L is a linker arm comprising a linear chain of at least two covalent bonds and n is an integer equal to 0 or 1, R 3 and R 4 represent, independently of one another: H, NO 2 , Cl, Br, F, I, R 2 -(L) n -Y—X—, OR, SR, NR 2 , R, NHCOR, CONHR, COOR, —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 3 —CH 2 —NH—R 2 , —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 4 —CH 2 —NH—R 2 with R=alkyl or aryl, A is a linker arm comprising at least one covalent double bond enabling the conjugation of the diazo function with the aromatic ring and u is an integer between 0 and 2, preferably 0 or 1, —Y—X— represents —CONH—, —NHCO—, —CH 2 O—, —CH 2 S—, —Z— represents —NH—, —NHCO—, —CONH— or —O—, m is an integer between 1 and 10, preferably between 1 and 3, and p is an integer between 1 and 10, preferably between 1 and 3. n The present invention also describes a method for the synthesis of said labels and also applications for the labeling of biological molecules, in particular of nucleic acids, with a labeling reagent bearing the diazomethyl function. n The invention is particularly suitable for use in the field of diagnostics.
专利号:US-3905999-A 优先权日:1972-06-20 标 题 :Synthesis of 2,3-substituted indoles 发明人:KRUTAK SR JAMES J 权利人:EASTMAN KODAK CO 摘要:A process for the production of 2,3-substituted indoles from Alpha -haloaldehydes or derivatives thereof and certain primary or secondary aromatic amines is disclosed. These indoles are useful in the production of Fischer type bases which are utilized as intermediates for the synthesis of cyanine dyes and photochromic compositions.
参考文献:10.1007/s10895-011-0919-y 摘要:Shanker N, Dilek O, Mukherjee K, McGee DW, Bane SL. Aurones: Small Molecule Visible Range Fluorescent Probes Suitable for Biomacromolecules. Journal of Fluorescence. 2011 Jul 12;21(6):2173. doi: 10.1007/s10895-011-0919-y. 参考文献:10.1007/s10565-011-9196-4 摘要:Jariyawat S, Thammapratip T, Suksen K, Wanitchakool P, Nateewattana J, Chairoungdua A, Suksamrarn A, Piyachaturawat P. Induction of apoptosis in murine leukemia by diarylheptanoids from Curcuma comosa Roxb. Cell Biol Toxicol. 2011 Dec;27(6):413–23. doi: 10.1007/s10565-011-9196-4. 参考文献:10.1007/s12672-011-0077-3 摘要:Gulliver LSM, Hurst PR. Novel Approaches to Quantify Estradiol-Induced Loss of ERβ1 Protein in Older Mouse Ovarian Surface Epithelium: New Tools to Assess the Role of ER Protein Subtypes in Predisposing to Ovarian Epithelial Cancer Discover Oncology. 2011 Jul 20;2(4):204. doi: 10.1007/s12672-011-0077-3. 参考文献:10.1007/s10495-011-0631-z 摘要:Kauntz H, Bousserouel S, Gossé F, Raul F. Silibinin triggers apoptotic signaling pathways and autophagic survival response in human colon adenocarcinoma cells and their derived metastatic cells. Apoptosis. 2011 Oct;16(10):1042–53. doi: 10.1007/s10495-011-0631-z. 参考文献:10.1007/s10295-011-1015-7 摘要:Wang J, Zhang W, Zhong Z, Wei A, Bao Q, Zhang Y, Sun T, Postnikoff A, Meng H, Zhang H. Transcriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk. Journal of Industrial Microbiology & Biotechnology. 2011 Jul 22;39(1):191–206. doi: 10.1007/s10295-011-1015-7.