CAS: 482-39-3; 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-3-(((2S,3R,4R,5R,6S)-3,4,5-Trihydroxy-6-Methyltetrahydro-2H-Pyran-2-yl)Oxy)-4H-Chromen-4-One

上下游产品

CAS号865484-73-7 Carbonic acid, ... | CAS号23405-70-1 5,7-BIS-(BENZYL... | CAS号1192-62-7 2-乙酰基呋喃 | CAS号96333-59-4 5,7-BIS-(BENZYL... | CAS号480-41-1 柚皮素； 4',5,7-三羟基黄烷酮 | CAS号247244-65-1 (S)-6-hydroxy-2... | CAS号520-18-3 山奈酚 | CAS号6014-42-2 鼠李糖

📜2-乙酰基呋喃置于tris(Dibenzylideneacetone)Dipalladium(0) Chloroform Complex,Palladium On Activated Charcoal,(R)-Ru(η6-Mesitylene)-(S,S)-Tsdpen 4-二甲氨基吡啶,Sodium Tetrahydroborate,N-溴代丁二酰亚胺(Nbs),四氧化锇,甲酸,N-甲基吲哚酮,氢气,Sodium Acetate,碳酸氢钠,三乙胺,三苯基膦体系中,用 四氢呋喃,甲醇,乙醇,二氯甲烷,水,丙酮,叔丁醇 作为反应溶剂,化学反应 52.0H,反应生成 阿福豆苷
参考文献:通过钯催化的糖基化从头开始不对称合成sl0101及其类似物.
标题:通过钯催化的糖基化从头开始不对称合成sl0101及其类似物.
摘要:天然山ka酚糖苷sl0101(1A)及其类似物1B-E及其对映异构体的对映选择性合成已通过7-10个步骤完成.这些途径依赖于非对映选择性钯催化的糖基化,酮还原和二羟基化以引入鼠李糖立体化学.这些山emp酚糖苷的糖部分的不对称性源自酰基呋喃的noyori还原.还描述了在基本条件下乙酰基从轴向(c-2)转移到赤道位置(c-3).[反应:看文字]
DOI:10.1021/ol062076R

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-9040673-B2
优先权日:2009-08-14
标题 :Synthesis and identification of novel RSK-specific inhibitors
发明人：HECHT SIDNEY M; LANNIGAN-MACARA DEBORAH A; SMITH JEFFREY ALLAN; O'DOHERTY GEORGE A; HILINSKI MICHAEL KENNETH
权利人:HECHT SIDNEY M; LANNIGAN-MACARA DEBORAH A; SMITH JEFFREY ALLAN; O'DOHERTY GEORGE A; HILINSKI MICHAEL KENNETH; Univ Virginia Patent Found
摘要:A composition comprising an SL0101 [kaempferol 3-O-(3″,4″-di-O-acetyl-α-L-rhamnopyranoside)] derivative compound that has enhanced ability to inhibit RSK activity, relative to the parent compound is provided. The compounds have utility for treating any disease or conditions characterized or associated with excess or undesirable RSK activity. For example the RSK inhibitors of the present invention can be used to reduce the proliferation of neoplastic cells or for inhibiting the establishment or maintenance of an intracellular pathogenic infection by pathogens whose pathogenicity derives in part from the pathogen's ability to impede endosomal/phagosomal maturation in the host cell.

专利号:EP-1493431-B1
优先权日:2003-07-03
标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
发明人：WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
权利人:MERCK PATENT GMBH
摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.

专利号:CN-110408649-B
优先权日:2019-07-25
标题:Application of NOR gene and its encoded protein in regulating the synthesis of flavonoids in tomato fruit

专利号:WO-2014034977-A1
优先权日:2012-08-30
标题:Composition for blocking uv rays or reducing skin wrinkles comprising afzelin as active ingredient
发明人：SHIN SEOUNG WOO; KIM JANG-HYUN; JUNG EUN SUN; PARK DEOK HOON
权利人:BIO SPECTRUM INC; DERMISKIN INC; SHIN SEOUNG WOO; KIM JANG-HYUN; JUNG EUN SUN; PARK DEOK HOON
摘要:The present invention relates to a cosmetic composition for blocking UV rays or reducing skin wrinkles, which contains afzelin as an active ingredient. The invention also relates to a pharmaceutical or food composition for reducing skin wrinkles, which contains afzelin as an active ingredient. The composition of the invention has an excellent effect of reducing wrinkles by absorbing UVA and UVB to prevent UV rays from penetrating the skin, increasing collagen synthesis and inhibiting collagenase activity. In addition, because the composition of the invention is derived from natural materials, it is harmless to the human body and can be safely applied to cosmetic, pharmaceutical and food compositions.

专利号:US-2012245112-A1
优先权日:2009-08-14
标 题:Synthesis and identification of novel rsk-specific inhibitors