CAS: 4066-39-1; 2-Amino-3-(Furan-2-yl)Propanoic Acid

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CAS号4066-14-2 (2Z)-3-(2-furyl... | CAS号121786-31-0 3-(2-呋喃基)-L-丙氨酸 | CAS号4066-17-5 9-(4-methoxyphe... | CAS号98-00-0 糠醇 | CAS号617-88-9 2-氯甲基呋喃 | CAS号4437-18-7 2-溴甲基呋喃 | CAS号110772-46-8 H-β-(2-呋喃基)-D-丙氨酸 | CAS号539-47-9 2-呋喃丙烯酸 | CAS号73495-08-6 (R)-3-Amino-3-(...

📜糠基氯置于lithium Hydroxide,Sodium Hydroxide,Sodium Hydride体系中,用 甲醇,N,N-二甲基甲酰胺,甲苯 作为反应溶剂,化学反应 32.0H,反应生成 2-呋喃丙氨酸
参考文献:杂芳基丙烯酸酯和丙氨酸与欧芹中的苯丙氨酸氨裂解酶的相互作用.
标题:杂芳基丙烯酸酯和丙氨酸与欧芹中的苯丙氨酸氨裂解酶的相互作用.
摘要:合成了在β位置被杂芳基取代的丙烯酸和丙氨酸,并进行了光谱表征(uv,Hrms,(1)h NMR和(13)c NMR光谱).杂芳基基团是呋喃基,噻吩基,苯并呋喃基和苯并噻吩基,并且在2-或3-位含有丙酰基侧链.前者是苯丙氨酸解氨酶(pal)的非常好底物,而后者是抑制剂.例外的是噻吩-3-基丙氨酸(一种中等的底物)和呋喃-3-基丙氨酸(惰性).讨论了这些例外的可能原因.从外消旋杂芳基-2-丙氨酸开始,它们的d-对映异构体通过立体破坏方法制备.由杂芳基-2-丙烯酸酯以高氨浓度制备杂芳基-2-丙氨酸的l-对映异构体.
DOI:10.1002/chem.200501034

专利信息

专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.

专利号:US-2009069334-A1
优先权日:2007-08-18
标题:Pyridazine based alpha-helix mimetics
发明人：REBEK JR JULIUS; BIROS SHANNON; MOISAN LIONEL; VOLONTERIO ALESSANDRO; MANN ENRIQUE; DALE TREVOR
权利人:SCRIPPS RESEARCH INST
摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available building block, 6. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a “wet faceâ€? along one side and a hydrophobic face along the other side of the helix.

专利号:US-2010022549-A1
优先权日:2008-07-23
标题 :Alpha-helix mimetic with functionalized pyridazine
发明人：REBEK JR JULIUS; MOISAN LIONEL; CARELLA ALEXANDRE; MANN ENRIQUE
权利人:SCRIPPS RESEARCH INST
摘要:The synthesis of new α-helix scaffolds mimicking i, i+3 or i+4, i+7 residues, was accomplished. The common pyridazine heterocycle originates from the easily available dimethyl pyridazine-3,6-dicarboxylate building block. These scaffolds may be thought of as synthetic counterparts of amphiphilic α-helices having a hydrophilic face along one side and a hydrophobic face along the other side of the helix.

专利号:US-2015045534-A1
优先权日:2011-12-23
标题:Process for the Synthesis of Therapeutic Peptides

专利号:EP-2794634-A1
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides

专利号:EP-2794634-B1
优先权日:2011-12-23
标 题:Process for the synthesis of ghrelin analogues