专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:US-2010249192-A1 优先权日:2007-12-11 标 题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase 发明人:LI CHUN SING; RAMTOHUL YEEMAN K; LECLERC JEAN-PHILIPPE 权利人:MERCK FROSST CANADA LTD 摘要:Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. n HetAr − W − X − Ar  (I)
专利号:US-4874770-A 优先权日:1986-02-27 标 题 :Aryl-substituted (N-piperidinyl)methyl- and (N-piperidinyl) methylazoles having antipsychotic properties 发明人:VAN WIJNGAARDEN INEKE; KRUSE CORNELIS; VAN DER HEYDEN JOHANNES A M; TULP MARTINUS T M 权利人:DUPHAR INT RES 摘要:The invention relates to new aryl-substituted (N-piperidinyl)methyl- and (N-piperazinyl)methylazoles having interesting pharmacological, notably antipsychotic, properties. n The compounds may be prepared in a manner known for the synthesis of analogous compounds and be processed to compositions according to known methods.
专利号:US-12398115-B2 优先权日:2019-04-09 标 题 :Chrysophaentin analogs and use thereof 发明人:SULIKOWSKI GARY A; FULLENKAMP CHRISTOPHER; KIM KWANGHO; JANA SOMNATH 权利人:UNIV VANDERBILT 摘要:Provided are 9-dechlorochrysophaentin analog compounds and the synthesis process thereof. The disclosed compound have remarkable antimicrobial activities that are comparable to, or even more potent than, the natural product chrysophaentin A. Also provided are method of inhibiting bacterial growth or treating bacterial infection by administering an effective amount of the disclosed compounds.
专利号:RU-2124006-C1 优先权日:1992-10-20 标 题 :Quinolone and acridine compounds, methods of their synthesis and pharmaceutical composition based on thereof
[参考文献]: Stephen P Muench, Et Al. Development Of A Triclosan Scaffold Which Allows For Adaptations On Both The A- And B-Ring For Transport Peptides. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3551-5.
合成参考文献
摘要:Yliniemelä-Sipari, S. M.; Piisola, A.; Pihko, P. M., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 44. 摘要:Yliniemelä-Sipari, S. M.; Piisola, A.; Pihko, P. M., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 51.