专利号:US-5023381-A 优先权日:1988-12-22 标 题 :Process for preparing an organic synthesis intermediate 发明人:PERDONCIN GIULIO; GIORDANO CLAUDIO; PAIOCCHI MAURIZIO; CASAGRANDE ROBERTO 权利人:ZAMBON SPA 摘要:A process is described for the preparation of 2-methoxy-6-propionyl-naphthalene, an intermediate in the synthesis of naproxen. n The process consists of Friedel-Crafts acylation of 2-methoxy-naphthalene, and obviates the drawbacks related to the use of nitrobenzene as solvent.
专利号:EP-0178580-B1 优先权日:1984-10-15 标题:Intermediates for the synthesis of carboxylic acids 摘要:The compounds of formula: in which Ar represents an aryl, possibly substituted; R represents a C1-C4 alkyl; X represents a hydrogen, chlorine, bromine or iodine atom, a hydroxyl, or an acyloxy, alkylsulphonyloxy or arylsulphonyloxy group; n represents 0 or 1, where if n=0 one of R1 and R2 represents a -CH2OH group and the other represents a hydrogen atom, and if n=1 both R1 and R2 represent hydrogen atoms; are useful intermediates in the preparation of alpha-arylalkanoic acids by rearrangement reactions. The compounds of formula I are prepared by reacting glycerin or one of its anlogues with the appropriate alkyl-aryl-ketone.
专利号:CN-114887656-A 优先权日:2022-06-06 标 题:A kind of preparation method of modified nanometer Hβ zeolite catalyst for selective synthesis of 6-acyl-2-methoxynaphthalene
专利号:EP-0178580-A2 优先权日:1984-10-15 标 题:Intermediates for the synthesis of carboxylic acids
专利号:US-5053533-A 优先权日:1987-07-28 标 题 :Process for preparing naproxen 发明人:GIORDANO CLAUDIO; VILLA MARCO 权利人:ZAMBON SPA 摘要:A process for preparing alpha-arylalkanoic acids is described, and more specifically a process which is particularly convenient from the industrial aspect for the synthesis of S(+)2-(6-methoxy-2-naphthyl)-1-propionic acid.
专利号:EP-0158255-A2 优先权日:1984-04-06 标题:Optically active ketals, processes for their preparation and their use in the synthesis of apha-arylakanoic acids
1: González-Jiménez J, Cortijo M. Resonance energy transfer between tryptophan-214 in human serum albumin and acrylodan, prodan, and promen. Protein J. 2004 Jul;23(5):351-5. doi: 10.1023/b:jopc.0000032655.26249.ba. 121(3):237-52. doi: 10.1016/s0009-2797(99)00111-8.
合成参考文献
摘要:Cunha, J. C.; Dedeiras, B.; Negrão, A. C. R.; Marques, M. M. B., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) . 参考文献:10.1023/b:jopc.0000032655.26249.ba 摘要:González-Jiménez J, Cortijo M. Resonance energy transfer between tryptophan-214 in human serum albumin and acrylodan, prodan, and promen. Protein J. 2004 Jul;23(5):351–5. doi: 10.1023/b:jopc.0000032655.26249.ba.