CAS: 265981-13-3; 2-Bromo-3-Iodopyridine

相似化合物

1032582-80-1 73290-22-9 884494-42-2

上下游产品

CAS号109-04-6 2-溴吡啶 | CAS号13534-89-9 2,3-二溴吡啶 | CAS号100523-96-4 2-溴-4-碘吡啶 | CAS号111971-31-4 4-(4-methylphen...

📜2-溴吡啶置于正丁基锂,二异丙胺,碘体系中,用 四氢呋喃,正己烷,甲苯 用作溶剂,以85%的收率获得2-溴-3-碘吡啶
参考文献:利用炔烃化学方法,可制备具有功能性侧基的聚噻吩的通用方法.
标题:利用炔烃化学方法,可制备具有功能性侧基的聚噻吩的通用方法.
摘要:由缩水甘油分四步制备了一种新型的多功能聚噻吩构建基3-(3,4-乙撑二氧噻吩)丙-1-炔(pyedot)(3),总收率为28%.Pyedot的乙二氧基桥上带有乙炔基,可通过炔烃化学进一步官能化.通过sonogashira偶联和点击化学的合成简便性,通过电聚合前后的转化获得了一系列功能化的聚噻吩衍生物,证明了其有用性.
Doi:10.3762/bjoc.12.265

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:CN-112209872-A
优先权日:2020-10-12
标题:A kind of synthesis technique of 2-bromo-4-iodo-3-picoline

专利号:CN-115557887-B
优先权日:2022-11-10
标题:Synthesis and biological activity of trifluoromethylpyridine derivatives based on Ugi reaction

专利号:CN-115557887-A
优先权日:2022-11-10
标题:Synthesis and Biological Activity of Trifluoromethylpyridine Derivatives Based on Ugi Reaction