专利号:US-9926291-B2 优先权日:2007-03-27 标 题 :Synthesis of thiohydantoins 发明人:OUERFELLI OUATHEK; DILHAS ANNA; YANG GUANGBIN; ZHAO HONG 权利人:SLOAN KETTERING INST CANCER RES 摘要:A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
专利号:US-7078572-B2 优先权日:2002-09-20 标题:Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors 发明人:KENDALL JOHN THOMAS 权利人:WYETH CORP 摘要:The invention is a process for the preparation of compounds of the Formula I: n nwhere R 1 , R 2 , R 3 , R 4 and R 5 are defined in the specification, which are intermediates useful for the preparation of tubulin inhibitors which are useful in the treatment of cancer.
专利号:US-7074837-B2 优先权日:2000-08-08 标题 :Processes for preparation of bicyclic compounds and intermediates therefor 发明人:NAKAYAMA KEIJI; MUTO MAKOTO; SAITO TATSURU; TANI YUICHIRO; AKIBA TOSHIFUMI 权利人:DAIICHI SEIYAKU CO 摘要:A process for preparing intermediate compound (VII), compound (VIII) and compound (XIV) which will be raw materials for the synthesis of a synthetic antibactrial compound, via compound (I) or compound (X) and then, compound (II), the compounds each being shown below; and novel compounds useful for the preparation.
专利号:CA-2498759-A1 优先权日:2002-09-20 标 题 :Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
专利号:EP-1539682-A2 优先权日:2002-09-20 标题 :Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
专利号:US-2005288486-A1 优先权日:2002-09-20 标 题:Process for the synthesis of intermediates useful for the synthesis of tubulin inhibitors
摘要:Wyatt, P. B., Science of Synthesis Knowledge Updates, (2014) 4, 1. 摘要:Ayaz, M.; De Moliner, F.; Morales, G. A.; Hulme, C., Science of Synthesis: Multicomponent Reactions, (2013) 1, 105.