CAS: 2036-41-1; 5-Methylpyrimidine

该化合物是一种七环有机化合物,其特点是在5点以甲基组替代一个火药环,这种结构改变增强了其在制药和农用化学合成中作为多用途中间体的效用.复合物展示出核生殖和生物电替代反应的有利反应,使其对构建复杂的分子框架很有价值.在标准条件下保持稳定,与普通溶剂的兼容性有利于实验室和工业环境中的处理. 5-甲基苯丙胺在开发活性药物成分和特殊化学品方面特别有用,因为其火药核心是功能化的关键辅助工具.产品通常以高纯度供应,以确保合成应用的一贯性能.

结构式图片

相似化合物

153286-94-3 10070-92-5 22868-76-4

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

2,6-dichloro-5-methylpyrimidine 5-methyl-pyrimidine-4-carboxylic acid 4,6-dichloro-5-methylpyrimidine 5-methyl-2,4,6-trichloropyrimidine 5-(bromomethyl)pyrimidine 2-dibromomethyl-pyrimidine 5-(4-methoxyphenyl)pyrimidine (5-methylpyrimidin-4-yl)methanamine

合成工艺路线路线简述

  • 13939-06-5 + 1780-31-0 = 2036-41-1 + 933683-35-3
    反应条件:1.1 Solvents: Acetonitrile,Water; 16 H,Ph 9.5,Rt -> 45 °C1.2 Reagents: Sodium Chloride Solvents: Ethanol; Overnight,-20 °C1.3 Reagents: Cesium Hydroxide Catalysts: Palladate(1-),[2′-(Amino-Kn)[1,1′-Biphenyl]-2-Yl-Kc]Chloro[2′-(Dicyclohexylphos... Solvents: 1-Methoxy-2-Propanol,Water; 15 H,80 °C
    标题:Palladium-Catalyzed Hydroxycarbonylation Of (Hetero)Aryl Halides For Dna-Encoded Chemical Library Synthesis
    作者:Li,Jian-Yuan; Miklossy,Gabriella; Modukuri,Ram K.; Bohren,Kurt M.; Yu,Zhifeng; Et Al
    参考文献:Bioconjugate Chemistry 日期:2019 卷标:30(8) 页码:2209-2215
5-甲基嘧啶-4-醇置于palladium-Barium Carbonate,氨,三氯氧磷体系中,化学反应生成5-甲基嘧啶
参考文献:Vanderhaeghe; Claesen,Bulletin Des Societes Chimiques Belges,1957,Vol. 66,P. 276,289
标题:Vanderhaeghe; Claesen,Bulletin Des Societes Chimiques Belges,1957,Vol. 66,P. 276,289

专利信息


专利号:US-9755163-B2
优先权日:2010-04-30
标 题:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof
发明人:LI JIAN; TURNER ERIC
权利人:ARIZONA BOARD OF REGENTS ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIV; ARIZONA BOARD OF REGENTS ACTING FOR OR ON BEHALF OF ARIZONA STATE UNIV
摘要:Synthesis of four coordinated palladium complexes and their applications in light emitting devices thereof.

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人:LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人:TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:WO-2024137329-A1
优先权日:2022-12-20
标 题:Methods for the synthesis of complement factor d inhibitors and intermediates thereof
发明人:HASHIMOTO AKIHIRO; TIPPARAJU SURESH KUMAR
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.

专利号:US-9324957-B2
优先权日:2010-04-30
标 题:Synthesis of four coordinated gold complexes and their applications in light emitting devices thereof
发明人:LI JIAN; TUMER ERIC
权利人:LI JIAN; TUMER ERIC; UNIV ARIZONA STATE
摘要:Synthesis of four coordinated gold complexes and their applications in light emitting devices thereof.
现货

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📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

合成参考文献


摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 258.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 160.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 121.
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 446.
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