CAS: 18997-19-8; Chloromethyl Pivalate

上下游产品

Methyl pivalate formaldehyd pivaloyl chloride chlorosulfuric acid chloromethyl esterR)-7t-amino-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester(6R)-7t-amino-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid 2,2-dimethyl-propionyloxymethyl ester 6-aminopenicillanic acid pivaloyloxymethyl ester (pivaloyloxy)methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate (pivaloyloxy)methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

氯甲基氯磺酸酯,三甲基乙酸置于四丁基硫酸氢铵,碳酸氢钠体系中,用 二氯甲烷,水 用作溶剂,化学反应 24.0H,反应生成特戊酸氯甲酯
参考文献:取代吡唑类化合物,其制备方法,药物组合物及用途
标题:取代吡唑类化合物,其制备方法,药物组合物及用途
摘要:一种式i所示的取代吡唑类化合物,其制备方法,药物组合物及用途.所述化合物具有非常好的稳定性,溶解性优异,对细胞毒性小,对神经保护作用效果显著,能够有效预防和治疗神经细胞损伤,是一种理想的预防或治疗:脑卒中,脑栓塞,脑卒中后遗症,脑卒中运动机能障碍,线粒体脑肌病,肌萎缩性脊髓侧索硬化症的药用化合物.

专利信息

专利号:US-8785629-B2
优先权日:2009-06-18
标题 :Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
发明人：AGROFOGLIO LUIGI A; ROY VINCENT; PRADERE UGO
权利人:AGROFOGLIO LUIGI A; ROY VINCENT; PRADERE UGO; CENTRE NAT RECH SCIENT; UNIV ORLEANS
摘要:Synthons for the synthesis of phosphonates prodrugs POM and POC, especially for direct Cross Metathesis.

专利号:WO-2014148928-A1
优先权日:2013-03-21
标 题:Method for incorporating protecting acetal and acetal ester groups, and its application for the protection of hydroxyl function
发明人：MARKIEWICZ WOJCIECH; TOÅš-MARCINIAK AGNIESZKA; CHMIELEWSKI MARCIN
权利人:INST CHEMII BIOORG POLSKIEJ AKADEMII NAUK
摘要:The present invention is the method for incorporation of acetal and acetal ester groups for protection of hydroxyl function. The method is applied in particular in the processes of RNA synthesis. The method can be employed in the synthesis of nucleosides with acetal and acetal ester groups for the protection of hydroxyl functions. The method according to the invention consists of the reaction of an organic compound containing at least one hydroxyl group, soluble in an aprotic solvent, with a compound of the general formula 1, R 1 -S-CH 2 -O-R 2 (1) in the presence of SnCl 4 , in an aprotic solvent. In the second aspect, the present invention is the method of protecting the hydroxyl function, particularly in position 2', in nucleoside derivatives, based on the incorporation of an acetal or acetal ester group.

专利号:US-8536318-B2
优先权日:2008-05-29
标题 :Chemical RNA synthesis method
发明人：DEBART FRANCOISE; VASSEUR JEAN-JACQUES; LAVERGNE THOMAS
权利人:DEBART FRANCOISE; VASSEUR JEAN-JACQUES; LAVERGNE THOMAS; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 2
摘要:The invention relates to a method for the chemical synthesis of RNA, comprising the following steps: a) bonding to a solid support of a monomer having formula (II) in which—X 1 is a dimethoxytrityl group,—X 6 is H or an OAc group or OX 3 , in which X 3 is a group having formula (A), in which X is O or S, R′ is H or CH 3 and R is selected from a linear or branched alkyl group at C 1 to C 4 and a R 1 —O—R 2 group in which R 1 is an alkyl group at C 1 to C 2 and R 2 is a CH 3 group or CH 2 CH 2 —O—CH 3 or aryl; b) assembly with the monomer having formula (II) bound to the support thereof obtained in step (a) of at least one monomer having formula (III) in which X 1 , Bp, X 3 are as defined for formula (II) and X 5 is a hydrogen phosphonate monoester or phosphoramidite group, preferably a 2-cyanoethyl-N,N-diisopropylphosphoramidite group, which is used to obtain a protected single-strand RNA bound to a support.

专利号:US-9963472-B2
优先权日:2013-11-04
标 题 :Stable pantetheine derivatives for the treatment of pantothenate kinase associated neurodegeneration (PKAN) and methods for the synthesis of such compounds
发明人：JENKO BRANKO; KOSEC GREGOR; PETKOVIC HRVOJE; PODGORSEK BERKE AJDA; PAHOR JERCA; CUSAK ALEN; SIBON ODA CORNELIA MARIA; SRINIVASAN BALAJI
权利人:ACIES BIO D O O; UNIV GRONINGEN; ACADEMISCH ZIEKENHUIS GRONINGEN
摘要:The invention relates to (S)-acyl-4′-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.

专利号:US-4255581-A
优先权日:1979-08-13
标题 :Process for the preparation of alkyl and aryl esters of 3'-substituted and 2', 3'-disubstituted 2-anilino-3-pyridinecarboxylic acids
发明人：LOS MARIO A
权利人:LAB BAGO S A
摘要:In this disclosure, the synthesis of alkyl and aryl esters of substituted 2-anilino-3-pyridinecarboxylic acids is described. This preparation is performed reacting a previously obtained alkyl or aryl ester of 2-chloro-3-pyridinecarboxylic acid, with 3,2 or 3-substituted aniline.

专利号:US-9605019-B2
优先权日:2011-07-19
标 题:Methods for the synthesis of functionalized nucleic acids
发明人：VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL
权利人:VERDINE GREGORY L; MEENA; IWAMOTO NAOKI; BUTLER DAVID CHARLES DONNELL; WAVE LIFE SCIENCES LTD
摘要:The present application, among other things, provides technologies, e.g., reagents, methods, etc. for preparing oligonucleotides comprising phosphorothiotriesters linkages, e.g., oligonucleotides having the structure of IIIa, IIIb or IIIc. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ia or Ib with a silylating reagent to provide a silyloxyphosphonate, and reacting the silyloxyphosphonate with a thiosulfonate reagent of structure IIa or IIb to provide an oligonucleotide of structure IIIa or IIIb. In some embodiments, provided methods comprise reacting an H-phosphonate of structure Ic with a silylating reagent to provide a silyloxyphosphonate, reacting the silyloxyphosphonate with a bis(thiosulfonate) reagent of structure IVc to provide a phosphorothiotriester comprising a thiosulfonate group of structure Vc, and then reacting the phosphorothiotriester comprising a thiosulfonate group of structure Vc with a nucleophile of structure VIc to provide an oligonucleotide of structure IIIc.