CAS: 166599-84-4; Benzofuran-4-Carboxylic Acid

该化合物是一种循环循环性芳烃化合物,在4点以一个箱状酸组取代苯并呋喃核心,在有机合成中,特别是在制药和农用化学中,这种结构具有适合用作多种用途中间体的回活动性,特别是在制药和农用化学中.箱状酸混合物允许进一步功能化,使氨化,酯或其他衍生物得以形成.它的硬质苯并呋喃脚架有助于稳定性和潜在的生物活动,使其在药物发现药物的药用化学中具有价值.该化合物的特点是高度纯度和一贯性,确保研究和工业应用的可靠性.建议适当处理和储存以保持其完整性.

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95333-17-8 41019-56-1 77095-51-3

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CAS号166599-85-5 methyl 2-hydrox... | CAS号41019-56-1 苯并呋喃-4-甲酸甲酯 | CAS号79250-46-7 methyl 3-prop-2... | CAS号79950-39-3 methyl 2-allyl-... | CAS号412336-07-3 1-苯并呋喃-4-胺 | CAS号209256-40-6 苯并二氢呋喃-4-甲酸 | CAS号412336-05-1 1-苯并呋喃-4-氨基甲酸叔丁酯

合成工艺路线路线简述

  • 合成目标产物 4-Benzofurancarboxylic Acid 主要起始原料 4-Benzofurancarboxylicacidmethylester
  • (文献来源)合成步骤主要原料 4-Benzofurancarboxylicacidmethylester
📜Methyl 3-(Allyloxy)Benzoate置于氢氧化钾,二甲基硫,磷酸,臭氧体系中,用 甲醇 用作溶剂,化学反应 2.92H,反应生成苯并呋喃-4-甲酸
参考文献:Aminoalkylindoles: Structure-Activity Relationships Of Novel Cannabinoid Mimetics
标题:Aminoalkylindoles: Structure-Activity Relationships Of Novel Cannabinoid Mimetics
摘要:Aminoalkylindoles (Aais) Are A Novel Series Of Cannabinoid Receptor Ligands. In This Report We Disclose The Structural Features Of Aais Which Are Important For Binding To This Receptor As Measured By Inhibition Of Binding Of [h-3]Win 55212-2 (5). Functional Activity In The Mouse Vas Deferens Is Also Noted And Used To Distinguish Agonists From Potential Antagonists. The Key Structural Features For Potent Cannabinoid Activity In This Series Are A Bicyclic (Naphthyl) Substituent At The 3-Position,A Small (II) Substituent At The 2-Position,And An Aminoethyl (Morpholinoethyl) Substituent At The 1-Position. A 6-Bromo Analog,Win 54461 (31),Has Been Identified As A Potential Cannabinoid Receptor Antagonist. Modeling Experiments Were Done To Develop A Pharmacophore And Also To Compare Aai Structures With Those Of Classical Cannabinoids. The Fact That The Cannabinoid Aais Arose Out Of Work On A Series Of Cyclooxygenase Inhibitors Makes Sense Now That An Endogenous Cannabinoid Ligand Has Been Identified Which Is A Derivative Of Arachidonic Acid. Because Of Their Unique Structures And Physical Properties,Aais Provide Useful Tools To Study The Structure And Function Of The Cannabinoid Receptor(S).
Doi:10.1021/jm00016A013

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专利信息


专利号:US-2009131688-A1
优先权日:2007-11-21
标 题 :Method for the synthesis of 4-benzofuran-carboxylic acid
发明人：BURGOS ALAIN; MARUANI MARTINE; PERRIN FLORENCE; FREIN STEPHANE
权利人:ZACH SYSTEM
摘要:The invention concerns a novel method for synthesis of 4-benzofuran-carboxylic acid or alkyl ester thereof. n This method is characterized in that a reaction for aromatization of a compound of formula (II) is performed for the synthesis of the compound of formula (I), according to the scheme A2 below: n n n n n n n n n n wherein R independently represents hydrogen or a linear or branched C 1 - 15 alkyl group. n With the invention, it is possible to industrially synthesize 4-benzofuran-carboxylic acid or alkyl ester thereof with good yield and very good purity.

专利号:WO-2009071799-A1
优先权日:2007-11-21
标 题 :Process for the synthesis of 4-benzofurancarboxylic acid

专利号:CN-116023388-A
优先权日:2023-02-24
标题:Hexahydrofuran [2,3-B ] benzofuran compound, preparation thereof and application thereof in synthesis of aflatoxin B intermediate

专利号:FR-2923826-A1
优先权日:2007-11-21
标 题 :PROCESS FOR THE SYNTHESIS OF 4-BENZOFURAN CARBOXYLIC ACID

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合成参考文献


摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 319.
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