CAS: 1658-42-0; Methyl 2-(Pyridin-2-yl)Acetate

该化合物是一种有机化合物,其特点是其环结构和一个酯功能组,其特点是附于2-丙烯乙酸的碳盒酸的甲基酯组,它有助于有机溶剂中的溶性.该化合物一般是无色的,可粉色黄色液体,具有独特的芳香味.由于存在氮和酯组,影响其化学过程中的再活动与相互作用,该化合物是中极的.2-丙烯乙酸经常用于有机合成,并用作生产药物和农用化学品的一种中间体.其特性包括一个相对较低的沸点,并倾向于参与核感激素替代反应,使其成为各种化学应用中的多用途建筑块.在处理该化合物时,应注意安全防范措施,因为如果吸入或吸入,可能会对健康造成危害.

结构式图片

相似化合物

16179-97-8 13115-43-0 103-74-2

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合成工艺路线路线简述

  • 合成目标产物 Methyl 2-Pyridylacetate 主要起始原料 Methanol And 2-Pyridylacetic Acid Hydrochloride
  • (文献来源)合成步骤主要原料 Methanol 和 2-Pyridylacetic Acid Hydrochloride
1-苯基-2-吡啶-2-基乙酮置于盐酸,氯化亚砜,乙醇,氯仿,盐酸羟胺,水,Sodium Acetate体系中,化学反应生成2-吡啶乙酸甲酯
参考文献:Oparina,Zhurnal Obshchei Khimii,1935,Vol. 5,P. 1699,1703
标题:Oparina,Zhurnal Obshchei Khimii,1935,Vol. 5,P. 1699,1703

海关参考信息

专利信息


专利号:US-7022691-B2
优先权日:2002-04-04
标题 :Inhibitors of serine and metallo-β-lactamases
发明人:BUYNAK JOHN D; CHEN HANSONG
权利人:BUYNAK JOHN D; CHEN HANSONG
摘要:Compounds of formula (I): n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting simultaneously serine and metallo-β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-7125986-B2
优先权日:1997-12-29
标题:Penicillanic acid derivative compounds and methods of making
发明人:BUYNAK JOHN D; RAO AKIREDDY SRINIVASA; DOPPALAPUDI VENKATA RAMANA
权利人:UNIV SOUTHERN METHODIST
摘要:Compounds of formula I: n nwherein R 1 , R 2 , R 3 , R 4 and n have any of the values defined in the specification, and their pharmaceutically acceptable salts, are useful for inhibiting β-lactamase enzymes, for enhancing the activity of β-lactam antibiotics, and for treating β-lactam resistant bacterial infections in a mammal. The invention also provides pharmaceutical compositions, processes for preparing compounds of formula I, and novel intermediates useful for the synthesis of compounds of formula I.

专利号:US-8926801-B2
优先权日:2009-01-16
标题 :Methods of electrospray chemical synthesis and device for use therein
发明人:REHMAN ATIQ
权利人:REHMAN ATIQ; CANAM BIORES INC
摘要:The present invention relates to methods of production of chemical bonds and subsequent molecules by electrospray ionization and the design of an electrospray chemical synthesizer, for use in chemical synthesis and expedited organic chemical reactions.

专利号:US-7019094-B2
优先权日:2002-05-31
标 题:Intermediate products, methods for their preparation and use thereof
发明人:WESTMAN JACOB; LUNDIN RONNY
权利人:BIOTAGE AB
摘要:Novel solid supported intermediate products of the general formula n ncoupled to a solid polymeric support through one or both of the R 1 groups or through the R 4 group which are suitable for synthesis of heterocyclic compounds are disclosed. Methods for preparing such intermediate products are also disclosed and also the use of the intermediate products in simple and fast methods on solid phase for synthesis of heterocycles.

专利号:US-8012220-B2
优先权日:2006-04-13
标题 :Specific monocationic monochromophoric compounds of hydrazone type comprising a 2-, 4-pyridinium or 2-, 4-quinolinium unit, synthesis thereof, dye compositions containing them, and method for dyeing keratin fibres
发明人:DAVID HERVE; MURGUET NADEGE; GREAVES ANDREW
权利人:OREAL
摘要:The present disclosure relates to monocationic monochromophoric compounds of formula (I) and (II) and dyeing compositions and multicompartment devices comprising monocationic monochromophoric compounds of formula (I) and (II). The disclosure also relates to methods for preparing monocationic monochromophoric compounds of formula (I) and (II), and also to methods for dyeing comprising applying monocationic monochromophoric compounds of formula (I) and (II) to keratin fibers.

专利号:US-9708336-B2
优先权日:2014-01-22
标题 :Metallo-beta-lactamase inhibitors
发明人:MANDAL MIHIR; TANG HAIFENG; XIAO LI; SU JING; LI GUOQING; YANG SHU-WEI; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; HICKS JACQUELINE; LOMBARDO MATTHEW; CHU HONG; HAGMANN WILLIAM; PASTERNAK ALEX; GU XIN; JIANG JINLONG; DONG SHUZHI; DING FA-XIANG; LONDON CLARE; BISWAS DIPSHIKHA; YOUNG KATHERINE; HUNTER DAVID N; ZHAO ZHIQIANG; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula (I) that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
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主要参考文献

参考标题:Rh(III)-Catalyzed Regio- And Chemoselective [4 + 1]-Annulation Of Azoxy Compounds With Diazoesters For The Synthesis Of 2H-Indazoles: Roles Of The Azoxy Oxygen Atom
作者:Zhen Long,Zhigang Wang,Danni Zhou,Danyang Wan,Jingsong You |发布日期:2017.6.2
摘要:Tandem C-H Alkylation/intramolecular Decarboxylative Cyclization Of Azoxy Compounds With Diazoesters For The Synthesis Of 3-Acyl-2H-Indazoles Is Disclosed. The Azoxy Instead Of The Azo Group Enables A Distinct Approach For Cyclative Capture, Leading To A [4 + 1]-Annulation Rather Than A Classic [4 + 2] Manner. The Azoxy Oxygen Atom Is Traceless After Annulation, And Further Removal From The Product Is

合成参考文献


摘要:Kiyokawa, K., Science of Synthesis: Hypervalent Halogens in Organic Synthesis, (2025) .
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