CAS: 147-61-5; 5-(Hydroxymethyl)-6-Methylpyrimidine-2,4(1H,3H)-Dione

该化合物是一种可应用于制药和生化研究的微米碘衍生物,其结构为5位置的氢氧化甲基组和6位置的甲基组,为进一步功能化提供了多种用途,该化合物因其作为核糖核酸合成前体的作用及其作为经修改的核酸类比建筑块的潜力而引人注意. 氢氧基和甲基替代组的存在增强了其再活性,使之适合于选择性的化学修改.其稳定的晶体形式确保了处理和储存的便利,而其定义明确的纯度支持了合成和药用化学应用中的可复制实验结果.

结构式图片

相似化合物

869891-41-8 858001-23-7 120129-83-1

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

5-(氯甲基)-6-甲基-2,4(1H,3H)-嘧啶二酮 5-(Chloromethyl)-6-Methyluracil 66947-91-9
6-甲基尿嘧啶 6-Methyluracil 626-48-2

合成工艺路线路线简述

    📜6-甲基尿嘧啶置于sodium Hydroxide体系中,化学反应生成5-羟基甲基-6-甲基尿嘧啶
    参考文献:Interaction Of Chloromethyl Ether With 4-Methyluracil.1,2 Ii
    标题:Interaction Of Chloromethyl Ether With 4-Methyluracil.1,2 Ii
    摘要:
    Doi:10.1021/ja01853A010

    海关参考信息

    专利信息


    专利号:US-2024327370-A1
    优先权日:2021-07-01
    标题:Process for the biobased synthesis of schweinfurthins g, k and r
    发明人:ROUSSI FANNY; LITAUDON MARC; DESRAT SANDY; JEZEQUEL GWENAËLLE; RAMPAL CÉLINE; PHAM VAN CUONG; DOAN THI MAI HUONG
    权利人:CENTRE NAT RECH SCIENT; VAST VIETNAM ACADEMY OF SCIENCE AND TECH
    摘要:The present invention relates to a process for preparing at least one schweinfurthin chosen from schweinfurthin G of formula (SW-G), schweinfurthin K of formula (SW-K) and schweinfurthin R of formula (SW-R), characterized in that it comprises a step of using mappain of formula (IV).

    专利号:US-4849513-A
    优先权日:1983-12-20
    标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
    发明人:SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
    权利人:CALIFORNIA INST OF TECHN
    摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

    专利号:US-5118802-A
    优先权日:1983-12-20
    标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
    发明人:SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
    权利人:CALIFORNIA INST OF TECHN
    摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

    专利号:US-9328109-B2
    优先权日:2013-01-14
    标 题:Process for the preparation of benzohetero [1, 3] diazole compounds disubstituted with heteroaryl groups
    发明人:BIANCHI GABRIELE; PO' RICCARDO
    权利人:ENI SPA
    摘要:Process for the preparation of a benzohetero-[1,3]diazole compound disubstituted with brominated heteroaryl groups which comprises reacting at least one dihalogenated benzohetero[1,3]diazole compound with at least one brominated heteroaryl compound. Said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used in the synthesis of compounds useful in the construction of solar concentrators (LSCs—“Luminescent Solar Concentratorsâ€?). Furthermore, said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used in the synthesis of photoactive polymers useful in the construction of photovoltaic devices (or solar devices) such as, for example, photovoltaic cells (or solar cells), photovoltaic modules (or solar modules), on both rigid or flexible supports. Furthermore, said benzohetero[1,3]diazole compound disubstituted with brominated heteroaryl groups can be advantageously used as precursor of monomeric units in the synthesis of semiconductr polymers.

    专利号:US-10100028-B2
    优先权日:2013-09-30
    标 题:Synthesis routes for prostaglandins and prostaglandin intermediates using metathesis
    发明人:YIANNIKOUROS GEORGE PETROS; KALARITIS PANOS; GAMAGE CHAMINDA PRIYAPUSHPA; AREFYEV DENIS VIKTOROVICH
    权利人:IRIX PHARMACEUTICALS INC; PATHEON API SERVICES INC
    摘要:Methods of synthesizing prostaglandins, prostaglandin analogs and their synthetic intermediates are described. The methods can comprise metal-catalyzed metathesis reactions. Also provided are synthetic intermediates that can be used in the synthesis of the prostaglandins and prostaglandin analogs.

    专利号:US-9000170-B2
    优先权日:2012-03-19
    标 题:Process for the preparation of tetracarboxynaphthalenediimide compounds disubstituted with heteroaryl groups
    发明人:SCHIMPERNA GIULIANA; PELLEGRINO ANDREA; CHIABERGE STEFANO; BIANCHI GABRIELE
    权利人:ENI SPA
    摘要:A process for the preparation of a tetracarboxynaphthalenediimide compound disubstituted with heteroaryl groups having general formula (I), comprising the reaction of at least one disubstituted N,N′-dialkyl-1,5,8-tetracarboxynaphthalenediimide with at least one heteroaryl compound. Said tetracarboxynaphthalenediimide compound disubstituted with heteroaryl groups can be advantageously used as monomer in the synthesis of semiconductor polymers which can be advantageously used in the construction of organic field effect transistors (OFET) or of organic thin film transistors (OTFT).

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1074/jbc.m106953200
    摘要:Boorstein RJ, Cummings A, Marenstein DR, Chan MK, Ma Y, Neubert TA, Brown SM, Teebor GW. Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1. J Biol Chem. 2001 Nov 09;276(45):41991–7. doi: 10.1074/jbc.m106953200.
    参考文献:10.1038/s41598-018-25124-1
    摘要:Papaluca A, Wagner JR, Saragovi HU, Ramotar D. UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans. Scientific Reports. 2018 May 01;8(1):6860. doi: 10.1038/s41598-018-25124-1.
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知